GTx Inc. (NASDAQ:GTXI) is a Memphis-based biopharmaceutical company founded in 1997 with a pipeline of synthetic small, hormone-mimic type drugs, the "selective androgen receptor modulators" (SARMs) and "selective estrogen receptor modulators" (SERMs). Today, a SERM, Capesaris (GTX-758), currently in a Phase IIb clinical trial (G200712), is discussed. It has been in 8 previous clinical trials. Capesaris is a SERM α-agonist under development for first- or second-line treatment of advanced or metastatic prostate cancers, i.e., Stages III and IV, here abbreviated as "m-PCA." The treatment goal for m-PCA is total systemic (body wide) androgen suppression or blockade, referred to as (surgical or chemical) castration. GTx's lead drug, enobosarm, was discussed in 2 previous articles. The second...
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