After many years of antibiotic over prescription, multi-drug-resistant (MDR) bacterial infections are a serious threat to our nation's health. It is estimated that over 3.5 million cases of MDR infection are encountered each year in the United States. The figure below summarizes the increasing incidence of antibiotic resistant bacteria. More recently, bacteria have evolved to resist even the most potent antibiotics, such as vancomycin, which comprise the last line of defense against MDR bacterial infection.
Figure 1: Thirty Years of Increasing Antibiotic Resistance
MRSA = methicillin-resistant staphylococcus aureus; FQRP = fluoroquinolone-resistant pseudomonas aeruginosa and VRE = vancomycin-resistant enterococci.
Despite this huge unmet medical need, limited resources have been deployed toward antibiotic research....
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