Jason Napodano, CFA
Research analyst, medium-term horizon, biotech, small-cap

Signal Vs. Noise: Neurocrine Experiences Second Hiccup With VMAT-2

On September 9, 2013, Neurocrine Bio (NASDAQ:NBIX) reported results from the much anticipated KINECT-1 trial, testing the company's small molecule VMAT2 inhibitor, NBI-98854, for the treatment of tardive dyskinesia. The KINECT-1 study enrolled a total of 109 patients with moderate-to-severe tardive dyskinesia (TD) with underlying schizophrenia or schizoaffective disorder. The trial took place at 33 sites around the U.S. Below we present a snap-shot of the patient profile for the KINECT-1 trial:

Investors can see this was a fairly well randomized trial, with baseline AIMS scores between the three arms offering adequate control. However, the AIMS (Abnormal Involuntary Movement Scale) assessment score varied greatly between the on-site rater, which consisted of 33 separate individuals at each study site

Join Seeking Alpha PRO to read this archived article and 11,574 other archived articles
FREESA PRO MEMBERS
IDEA GENERATORXExclusive access to 10 PRO ideas every day
INVESTING IDEAS LIBRARYXExclusive access to PRO library of more than 15,000 ideas
SECTOR EXPERT NETWORKXExclusive access to all sector experts for direct consultation
PERFORMANCE TRACKINGXTrack performance of all PRO stock ideas
PROFESSIONAL TOOLSXProfessional Idea Filters to zero-in based on industry, market cap and more
"In just the first month of using PRO, I used it to generate two ideas which were actionable for me. As a result of these two positions, I have earned more than 20 times the annual subscription costs for PRO."Michael Yagemann, Greenbridge Capital
"I am pleasantly surprised with the scope of small and mid-cap coverage PRO offers. You can't find that any where else."Patrick Rice, Mainstay Capital Management
You may cancel at any time for any reason, and receive a prompt refund for membership on months paid and not used (max. 6 months). Details