Physicians are becoming increasingly aware that inflammation plays a central role in our health. Chronic inflammation is associated with a wide diversity of seemingly unrelated diseases such as arthritis, cardiovascular disease, and even cancer. More problematically, researchers are now discovering that inflammation is often the underlying cause of health problems, not simply a symptom of them. Yet, anti-inflammatory treatments are essentially still in their infancy, with NSAIDs being by far the drug(s) of choice.
Chronic inflammatory conditions have a similar molecular basis across tissue types, with proinflammatory cytokines Interleukin-1 α and β being key mediators in the process. Although the biochemical cascade involved in generating an inflammatory response is mind-bogglingly complex, the IL-1 pathway governs a number of diseases, making...
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