Henry Su
Event-driven, long only, healthcare

Positive Phase 2 Results For Prana Biotechnology In Huntington's Disease: Behind The Smoke And Mirrors

Executive summary:

  • PBT2 is safe.
  • One serious adverse event occurred secondary to PBT2. A worsening of Huntington's disease symptoms upon its cessation.
  • PBT2 may improve cognition.
  • Efficacy of PBT2 required for approval in Huntington's disease is very low.
  • Approval of PBT2 for Huntington's disease will speed up approval for the larger Alzheimer's dementia indication.
  • IMAGINE trial results for Alzheimer's dementia due to report by the end of March significantly de-risked by the REACH2HD trial.

Prana Biotechnology (NASDAQ:PRAN) has recently released the results of its REACH2HD trial, which it has described as a success.

I have previously written about PBT2 more generally, whereas the focus of this article is to address some issues people have raised about the...

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