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To coin a L’Oréal phrase, in the eyes of Astellas Pharma (OTCPK:ALPMF), OSI Pharmaceuticals (OSIP) is definitely ‘worth it’. Having conducted its due diligence of OSI’s private books, Astellas Sunday raised its original hostile offer of $52 cash per share to an accepted bid of $57.50 cash per share, valuing the deal at $4bn, the second biggest overseas acquisition by a Japanese pharma company.

Big sighs of relief all round then at Astellas, who failed to land CV Therapeutics last year and adopted a slightly risky approach to bidding for OSI. But it now looks set to increase its presence in the US market and gain a portfolio of marketed and pipeline cancer drugs, most notably lung cancer drug Tarceva. As for OSI, some ambitious shareholders will be disappointed with the price as the stock reached $59.80 on Friday, but given that the offer is a 55% premium overall and equivalent to a five-year high, they should be more than happy.

Suitable compromise

Since Astellas launched its hostile bid in March, the bid process has been surrounded by rumors and speculation that Astellas would not budge from its hostile price or that a white knight would rescue OSI instead (Astellas goes hostile again, OSI the target, March 1, 2010).

However, since OSI opened its books to Astellas, the most likely outcome appeared to be a compromise with an improved offer from Astellas, but not at the chunky premium that an overly excited market was hoping for.

OSI shareholders are likely to have until May 31st to tender their shares at the revised price. Until now, less than 0.5% of shares had been sold to Astellas but that is bound to change dramatically over the next two weeks, especially if OSI’s biggest investors - JGD Management, Wellington Management and BlackRock Global Investors with a combined share of 22.6% - decide to take up this improved offer.

In early trade Monday OSI’s shares homed in on the offer price, slipping 4% to $57.37, suggesting some bullish investors will have to absorb any losses and just accept Astellas’ offer.

Second biggest overseas acquisition

Aside from the mergers and general consolidation within Japanese pharma companies of the last six years, an Astellas-OSI tie up would rank as the second biggest M&A deal, as data from EvaluatePharma below reveals.

The stand out deal of recent years is Takeda’s (OTCPK:TKPHF) $8.8bn acquisition of Millennium Pharmaceuticals, a company with a similar profile in many respects to OSI, although the premium Takeda paid of 17 times sales looks on the high side.

Top 10 Japanese Pharma Overseas Acquisitions
Rank Acquiring Company Target Deal Value ($m) Sales Multiple Deal Date
1 Takeda Millennium Pharmaceuticals 8,800 17x May-2008
2 Astellas Pharma OSI Pharmaceuticals 4,000 9x May-2010
3 Daiichi Sankyo (OTC:DSKYY) Ranbaxy Laboratories (majority stake) 3,950 n/a Nov-2008
4 Eisai (OTCPK:ESALY) MGI Pharma 3,900 9x Jan-2008
5 Dainippon Sumitomo Pharma (OTC:DNPUF) Sepracor 2,600 2x Oct-2009
6 Shionogi (OTC:SGIOF) Sciele Pharma 1,446 4x Oct-2008
7 Astellas Pharma Agensys 537 n/a Dec-2007
8 Hisamitsu Pharmaceutical (OTC:HTSUF) Noven Pharmaceuticals 428 4x Aug-2009
9 Eisai Morphotek 325 n/a Apr-2007
10 Taisho Pharmaceutical PT Bristol-Myers Squibb (NYSE:BMY) Indonesia 310 n/a Oct-2009

The Astellas-OSI deal also has many similarities to Eisai’s $3.9bn purchase of MGI Pharma, also priced at around 9 times sales.

The fact that all ten of the biggest deals have been struck within the last three years provides further evidence of Japanese pharma’s broadening horizon, if any were needed.

Impact on partnering?

Last year, Astellas was the most active Japanese company on the product licensing front, licensing 10 products with $280m paid upfront for deals with a combined value of $1.45bn. This ranked Astellas in the eighth spot in the global league of big pharma companies, even ahead of the likes of Pfizer (NYSE:PFE), Eli Lilly (NYSE:LLY) and Novartis (NYSE:NVS).

By far its biggest single deal was for Medivation’s (MDV) prostate cancer drug, MDV3100; it paid $110m upfront and agreed to a further $655m in developmental and commercial milestones. Clearly OSI’s experience and infrastructure within oncology should help Astellas maximize the chances of turning MDV3100 into a regulatory and commercial success.

However, having just burnt two-thirds of its current cash pile of $5.75bn and facing the standard integration issues that such a large acquisition presents – OSI currently employs over 500 staff - the inevitable question is how much the OSI deal will detract from Astellas’ ongoing and future licensing activities.

For the next 6-12 months Astellas’ current position as a major partner of choice, up there with the big pharma players, may need to be revised.

Source: Astellas Finally Joins Peers With Major Overseas Acquisition