You may not have thought to look northward for biotech innovators, but Bloom Burton & Co. co-founder and president, Brian Bloom can show you some truly hot Canadian companies with compelling skill sets and pipelines. In this interview with The Life Sciences Report, Bloom talks about his firm's upcoming conference, and presents a detailed picture of some very interesting companies that could return doubles, triples or more.
The Life Sciences Report: Does your firm perform any buy-side activities, or are you strictly a sell-side organization performing investment banking, advisory and research functions?
Brian Bloom: We offer a fully integrated platform of services that work together to capitalize, advise and grow extraordinary healthcare companies, and we operate almost exclusively in the Canadian space. We have many different services, including capital raising, merger and acquisition, advisory, equity research, scientific, clinical and medical consulting, company formation, which is a merchant banking function and, finally, direct investments.
We've brought this model to Canada. We may be unique in that we work not just with companies and investors, but we also perform advisory services for a lot of academic organizations in their work in starting up companies, and additionally, with building companies from scratch.
TLSR: Your third annual Bloom Burton & Co. Healthcare Investor Conference is on June 17-18. Do you have a theme for the conference?
BB: The theme is simply to find the best companies in Canada, where we have a universe of about 120-140 publicly listed companies, most of which are on the Toronto Stock Exchange [TSX] and some of which are also on the Nasdaq. There are also hundreds of private life sciences companies here in Canada. We try to choose the best 45 or so companies to showcase to global investors who come to Toronto.
It's a myth that there are lots of great companies and no capital. A lot of capital is out there, and partners like Bloom Burton & Co. can help curate a list of the highest-quality companies. That is the purpose of this investor conference.
TLSR: With your proximity to the U.S., I'm wondering how much interest and support you get from Wall Street.
BB: The majority of our attendees are Canadian, but we have a lot of interest and attendance from healthcare specialist investors who travel from New York, Boston, San Francisco and Europe. We often reach out to, and have lead orders for our transactions from, American healthcare specialist investors, including venture capital, hedge funds and private equity investors or lenders. Historically, these firms drive most of our transactions, and it's the Canadians who generally follow, because they don't have that expertise in the life science sector.
Canada is interesting in that we have a long history of risk investing, or investing in small-cap companies. The world comes to Canada for mining, oil and gas and other natural resource plays, because we are the leaders in growth capital and risk capital in that sector. But the United States - namely Boston, New York and San Francisco - is where the world goes for risk capital in life sciences.
TLSR: Because of their experience with resource investing, Canadian investors are not risk-averse?
BB: Yes, but with a caveat. Biotechnology companies are incredibly risky investments. Canadians are very comfortable with risky investments, but have had a long history of losing lots of money in biotechnology because of their lack of expertise in the sector, or lack of understanding the nature and timing of the risks associated with investing in the sector. As you know, biotech is probably the riskiest sector to invest in. You either have to have a lot of expertise or be crazy to invest in biotechnology. From patent, to scientific, to clinical, to regulatory, to commercial and reimbursement, the risks are extraordinary, and there are only a few thousand investors across a couple of hundred funds in the world who do this kind of investing as specialists.
TLSR: The resource sector is a bit softer now. Could that be moving Canadians more into biotech?
BB: The natural resources markets are softer, and therefore, Canadians are looking to put their money into other sectors, such as healthcare. It hasn't been into emerging, research-stage biotechnology companies; instead, it has been our commercial-stage healthcare companies, such as Paladin Labs [a unit of Endo Pharmaceuticals Inc. (NASDAQ:ENDP)], Knight Therapeutics Inc. (OTC:KHTRF, [GUD:TSX]), Concordia Healthcare Corp. (OTCQX:CHEHF, [CXR:TSX]), Cipher Pharmaceuticals Inc. (CPHMF, [DND:TSX]) and Merus Labs Inc. (MSLI, [MSL:TSE]). Those five and others are specialty pharmaceutical companies, smaller versions of U.S.-based Forest Laboratories Inc. (NYSE:FRX), Endo, Auxilium Pharmaceuticals Inc. (NASDAQ:AUXL) and Jazz Pharmaceuticals Plc (NASDAQ:JAZZ), which have commercial-stage sales and marketing organizations, and only selectively perform late-stage development work.
American investors have embraced biotechnology and early science and clinical development-stage companies, which has resulted in a very strong IPO window, resulting in billions of dollars being funneled into the biotechnology sector. On the other hand, Canada is experiencing an incredibly strong bull market, but only in specialty pharmaceutical and other commercial sectors.
TLSR: Let's talk stocks. Do you have a top pick?
BB: My top pick happens to be a biotechnology company called Trillium Therapeutics Inc. (OTCQX:SCTPF, [TR:TSX]), a company that changed its name from Stem Cell Therapeutics on June 2. Trillium operates in the immune-oncology space, one of the keenest areas of interest to both the pharmaceutical and investment industries right now. There are very few pure-play immune oncology companies, given that most of the research is performed by multinationals such as Bristol-Myers Squibb Co. (NYSE:BMY), AstraZeneca Plc (NYSE:AZN), Merck & Co. Inc. (NYSE:MRK), Roche Holding AG (OTCQX:RHHBY) and others. There are some pure-play smaller companies that have assets involved in immune oncology, namely Celldex Therapeutics Inc. (NASDAQ:CLDX) in the U.S. and Innate Pharma SA (OTCPK:IPHYF, [IDD:FKT]) in France.
Trillium is developing an antibody-like molecule called SIRPaFc. It's a soluble ligand dimerized with an Fc region that targets a protein called CD47, which is expressed on the surface of tumor cells. CD47 sends a "do-not-eat-me" signal, thereby protecting tumor cells from phagocytosis by macrophages. Cancers and cancer stem cells specifically express CD47 to evade macrophages, which are central elements of the innate immune system.
Macrophages normally survey tissues in the body for foreign elements, such as bacteria and viruses, engulf them and subsequently present antigens to acquire immunity against those invaders. Cancer cells overexpress CD47 to hide from the immune system so they can continue to proliferate and metastasize.
TLSR: Trillium has a couple of Phase I assets, yet is treating the pre-clinial SIRPaFc as its lead candidate. Does that mean the company is going to put all its focus into SIRPaFc?
BB: We believe that almost all the value and future upside of Trillium is in SIRPaFc. From a competitive point of view, there is a scarcity of assets that target CD47. Irving Weissman at Stanford University has received more than $30 million [$30M] in California taxpayer money to explore his anti-CD47 antibody, which will soon enter clinical trials. In addition, Celgene Corp. (NASDAQ:CELG) recently announced a very early-stage antibody program that targets CD47. We believe Trillium is ahead of Celgene on this front, and is fast on the heels of the Stanford program - and that Trillium Therapeutics could be in clinical trials with SIRPaFc by the middle of 2015.
TLSR: You raised $33M for the company in December 2013. How far will this take Trillium?
BB: Trillium is now fully funded through Phase I/II clinical trials, and this is very meaningful. This will allow the company to get Phase II data in acute myeloid leukemia [AML] and possibly in other liquid and solid tumor indications.
TLSR: The other pre-clinical program is an anti-CD200 fully human monoclonal antibody, not a fusion protein like SIRPaFc. This antibody acts as an immunosuppressant, and is overexpressed in many hematopoietic and even solid tumors. Is this something you are valuing in your models currently, or is it taking a backseat to SIRPaFc?
BB: It is definitely taking a backseat. The anti-CD200 asset was discovered at Trillium Therapeutics well before the SIRPaFc program, and over the past decade, the target has been the subject of partnerships with big biopharmas. You referred to CD200 as an immunosuppressant, yet CD200 biology is not as straightforward as CD47 biology. The problem here is that it is not inhibitory in all situations, and like many immunological targets, it can be suppressive or activating. When Trillium had this partnered with very large companies, it was not obvious in which disease indication it might be brought forward.
Alexion Pharmaceuticals Inc. (NASDAQ:ALXN) also owns an anti-CD200 program, and it conducted a Phase I/II clinical trial in oncology, but the company seems to have ceased development. CD200 is still waiting for basic biology to catch up to its promise as a target.
TLSR: We won't see SIRPaFc in the clinic until mid-2015. What moves this stock for investors?
BB: It will be the migration to a U.S. exchange, allowing for much broader exposure to a sophisticated U.S. audience that will understand the importance of Trillium's program. The company is not only completing its investigational new drug-enabling work right now - the chemistry, manufacturing and controls - but it is also dramatically expanding its pre-clinical program to test SIRPaFc in multiple liquid and solid tumor animal models, in combination with other chemotherapeutic and biologic anticancer agents, as well as in combination with other immune-oncology agents. The company could be worth manifold what it is today, based on this work.
TLSR: When does Trillium Therapeutics move forward and attempt to get a Nasdaq listing?
BB: I don't believe Trillium has said just yet on which exchange, or when. It wants to list in the U.S., and the company has certainly sent a signal to the market with its name change from Stem Cell Therapeutics to Trillium Therapeutics. At its last annual shareholder meeting, Trillium was granted permission from its shareholders to reverse-split its stock, and I believe the company could seek a U.S. listing in the second half of 2014.
TLSR: What other companies do you wish to discuss?
BB: Tekmira Pharmaceuticals Inc. (TKMR) is a leader in RNA interference [RNAi] formulation and delivery technologies. The company combines elements of Alnylam Pharmaceuticals Inc. (NASDAQ:ALNY), which is the platform technology leader in RNA interference technology, with elements of Arrowhead Research Corp. (NASDAQ:ARWR), which is laser-focused on certain diseases indications and specific products.
Tekmira is carving out a niche as a leader in the RNAi approach to infectious disease. It has programs in hepatitis B, as well as in Ebola virus disease, which used to be known as hemorrhagic fever, a severe and too often fatal disease in humans. There are some legacy programs in oncology, both partnered and being developed by Tekmira. We also understand that the company is exploring genetic orphan diseases.
TLSR: This company has a solid small-cap valuation of about $US300M. How is it positioned for all these difficult development programs you're talking about?
BB: Tekmira has raised approximately $90M in follow-on offerings over the past year, and it had more than $US130M in cash on its balance sheet on March 31. The company is cashed up, and the financial risk has therefore been dramatically diminished. It has cash to fuel research and development for many years. The enterprise value, at about $US170M, is trading at a significant discount to its peers, and the company has a very strong scientific team, as well as a very impressive clinical and regulatory team and experienced leadership. We believe all these factors combine to make Tekmira Pharmaceuticals one of the most undervalued and exciting biotechnology companies around.
TLSR: Tekmira's long list of indications looks very difficult because these are all systemic diseases. What does Tekmira have that's special? How does it get around oligonucleotide delivery problems?
BB: Delivery is a huge challenge for all RNAi companies. Tekmira's claim to fame is its lipid nanoparticle [LNP] formulation technology, which delivers systemic RNA/LNA particles to the liver and other organs.
Tekmira has been able to fine-tune both the size and nature of its LNPs to work in various situations. It has partnerships and cross-license agreements with other pharmaceutical companies, and through many successive generations of technology improvements, I anticipate Tekmira might expand its pipeline with products that target organs other than the liver.
TLSR: Brian, I thank you.
This interview was conducted by George S. Mack of The Life Sciences Report and can be read in its entirety here.
Brian Bloom is a cofounder of Bloom Burton & Co., and serves as the firm's president and head of institutional sales and capital market activities. By forging unique relationships with international healthcare-specialized investors, Bloom attracts capital for growing companies seeking to accelerate returns for investors. Before cofounding Bloom Burton, Bloom spent six years at Dundee Securities in the healthcare and biotechnology institutional sales and equity research groups. Earlier in his career, he spent two years in the equity research group at a New York-based merchant banking firm, SCO Group, and was an investment banking analyst at M&A advisory firm, Molecular Securities. Bloom is a member of the Life Sciences Advisory Board at the National Research Council of Canada and the Board of Directors at BIOTECanada. Bloom received an Honors Bachelor of Science degree in biochemistry from McMaster University and subsequently studied at the Mount Sinai Graduate School for Biological Sciences of New York University with a focus in molecular endocrinology and biophysics.
1) George S. Mack conducted this interview for Streetwise Reports LLC, publisher of The Gold Report, The Energy Report, The Life Sciences Report and The Mining Report, and provides services to Streetwise Reports as an independent contractor. He owns, or his family owns, shares of the following companies mentioned in this interview: None.
2) The following companies mentioned in the interview are sponsors of Streetwise Reports: None. Streetwise Reports does not accept stock in exchange for its services.
3) Brian Bloom: I own, or my family owns, shares of the following companies mentioned in this interview: Trillium Therapeutics Inc. I personally am, or my family is, paid by the following companies mentioned in this interview: None. My company has a financial relationship with the following companies mentioned in this interview: Trillium Therapeutics Inc. and Tekmira Pharmaceuticals Inc. I was not paid by Streetwise Reports for participating in this interview. Comments and opinions expressed are my own comments and opinions. I had the opportunity to review the interview for accuracy as of the date of the interview and am responsible for the content of the interview.
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