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Moving from a bulletin board listing to a major exchange is a major milestone for small companies as this event has the potential to raise their investment profiles, improve stock liquidity, increase visibility with current and potential investors, and thereby raise stock prices. Here are five that made such a jump in June.

Comstock Mining (NYSEMKT:LODE) moved to NYSE Amex on June 10. The company is a Nevada-based gold and silver mining company with extensive, contiguous property in the Comstock District. The company began acquiring properties in the Comstock District in 2003. Since then, the company has consolidated a significant portion of the Comstock District, amassed the single largest known repository of historical and current geological data on the Comstock region, secured permits, built an infrastructure and brought the exploration project into test mining production. The Company continues acquiring additional properties in the district, expanding its footprint and creating opportunities for exploration and mining. The goal of its strategic plan is to deliver stockholder value by validating qualified resources (at least measured and indicated) and reserves (probable and proven) of 3,250,000 gold equivalent ounces by 2013, and commencing commercial mining and processing operations in 2011, with annual production rates of 20,000 gold equivalent ounces.

Primus Telecommunications Group (NYSE:PTGI) began trading on the NYSE on June 23. The company is a provider of advanced communication solutions, including traditional and IP voice, data, mobile services, broadband Internet, collocation, hosting, and outsourced managed services to business and residential customers in the United States, Canada, Australia, and Brazil. Primus is also one of the leading international wholesale service providers to fixed and mobile network operators worldwide. Primus owns and operates its own global network of next-generation IP soft switches, media gateways, hosted IP/SIP platforms, broadband infrastructure, fiber capacity, and data centers located in Canada, Australia, and Brazil.

API Technologies (NASDAQ:ATNY) started trading on Nasdaq on June 27. The company designs, develops and manufactures electronic systems, subsystems, RF and secure solutions for technically demanding defense, aerospace and commercial applications. API Technologies' customers include many leading Fortune 500 companies.

Echo Therapeutics (NASDAQ:ECTE) began listing on Nasdaq on June 29. Echo is developing the Symphony tCGM System as a non-invasive, wireless, transdermal continuous glucose monitoring system for patients with diabetes and for use in hospital critical care units. Echo is also developing its needle-free Prelude SkinPrep System as a platform technology for enhanced skin permeation for delivery of topical pharmaceuticals.

57TH Street General Acquisition (NASDAQ:CRMB) started trading on Nasdaq on June 30. The company was formed in Delaware in October 2009 and acquired its interest in its subsidiary, Crumbs Holdings, in May 2011. The first Crumbs bake shop opened its doors in March 2003 on the Upper West Side of Manhattan by co-founders Mia & Jason Bauer. The design of Crumbs Bake Shops is inspired by old-time neighborhood bakeries, creating a warm and friendly environment with wall-to-wall treats. Recently ranked the largest retailer of cupcakes nationwide and one of Inc. Magazine’s 10 Breakout Companies of 2010, Crumbs currently has 35 locations, including 25 locations in the New York Metro area, six locations on the West Coast, two locations in Washington, D.C., one location in Virginia and one location in Chicago. The specialty of the house is cupcakes; however, the menu also includes an irresistible blend of comfort-oriented classics and elegant baked goods. There are more than 60 varieties of cupcakes baked fresh daily with a new cupcake of the week debuting each Monday.

Disclosure: I have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours.

Source: 5 OTCBB Stocks That Began Trading on Major Exchanges in June