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Below we highlight the best and worst performing US equities so far this year. As shown, most of the winners fall under the "Micro-Cap" category, with Walter Industries (WLT) and McMoRan Exploration (MMR) being the only gainers with over $1b in capitalization. The losers include several former billion dollar companies, Ambac (ABK) and First Marblehead (FMD) probably the most notable.

MiddleBrook Biopharmaceuticals (MBRK), headquartered in Germantown, MD, has been the best performing US stock this year, up 255%. Keryx Pharmaceuticals (KERX), headquartered in New York, NYm has been the worst performing US stock, down 94.5% year to date.

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Source: The Best and Worst Performing Stocks in the U.S.