One drugmaker has figured out how to pull down $2.52 billion over the next six months off a single disease – here’s how to get your piece of the action.

It could easily have been a headline from the 19th century.

In a market like this one, it pays to note the subtle differences between ostensibly similar assets.

For example, there are car stocks and then there are car stocks. (Yes, I am writing about cars again, but not for the whole column, honest!)

Is it the prospect of global recovery or the prospect of inflation that's driving oil prices higher? You don't have to choose – the opportunity for profit is there either way.

So far over the past several columns, I have written to you about cars and tires. So today, let’s talk about something completely different. How about oil?

More cold hard facts as to just how deep in debt we really are.

I promise to stop soon. I really do.

Washington will almost certainly cave into GM's extortion. They always have and always will.

So, how was the trolley ride to work today? Were you able to get a seat, or did you have to hang onto a strap?

Make 203% as Washington becomes a global laughing stock

According to our nation's new "Intel Czar," the economy is the number one threat to the U.S. right now.

In testimony before the Senate Intelligence Committee, National Intelligence Director Dennis Blair warned that: "The longer it takes for the recovery to begin, the greater the likelihood of serious damage to U.S. strategic interests."

Times are tough all over, and that MIGHT just be a good thing.

I have a confession to make: In the summer of 1974, I seldom wore a jacket and tie. It wasn’t so much that I had abandoned all efforts at propriety or decorum. I just had precious few reasons to dress properly.

Ride OPEC's outrage to 70% gains

"I am shocked – SHOCKED – to discover that there is gambling going on here."

– Captain Renault (Claude Raines, Casablanca, 1942)

Make 121% when Amazon (AMZN) announces the true cost of surviving the washout of 2008.

Circuit City (CCTYQ.PK) is really dead this time. They've had troubles in the past. In fact, they've threatened to go belly up most every time the economy stalls a bit. But this go round they have sold out down to bare walls, and then padlocked the doors.

Is it time to buy yet? If you are willing to close your eyes and hold your nose, you might just make 75% by summer.

You’ve got to love a business that does most of its work looking in the rearview mirror whilst simultaneously plunging ahead at 90 mph.

The Federal Deposit Insurance Corporation’s list of 117 “problem banks” is growing, according to its latest press release. The number of banks that may have squandered away their depositors’ cash is up 30%, quarter over quarter, the highest it’s been in more than five years.

What’s more, the FDIC anticipates that this list will surely grow over the next few months or maybe even weeks, as profits are down some 87% compared to the same quarter last year.