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  • A Study Of Arena's Lorcaserin Against The Backdrop Of Several Anti-Obesity Mechanisms [View article]
    Thanks, let me try and answer your questions to the best of my knowledge:

    1. Arena claims that Lorcaserin is selective, and it only activates 2C. Of the 14 subtypes of 5-HTs, 2C is thought to be more conducive to anti-obesity. However, all these agonists increase serotonin levels, which is widely feared to create fibrosis, especially in the heart. These are also the 2A/2B side effects.

    2. Post marketing surveillance/studies are not unusual per se. What is noteworthy is that the study focuses on long term cardiac risks - an issue that has been central to Lorcaserin's approval process for over 2 years, not only in the US but also in the EU.

    3. I don't know.

    4. I am unsure about its long-term prospect.

    Hope that answers your questions. Thanks for being polite.
    Jun 5, 2013. 02:42 AM | 1 Like Like |Link to Comment
  • A Study Of Arena's Lorcaserin Against The Backdrop Of Several Anti-Obesity Mechanisms [View article]
    Raising questions that are important is a worthwhile purpose.
    Jun 5, 2013. 02:22 AM | 3 Likes Like |Link to Comment
  • Where Is Pfizer Heading With The Patent Cliff? [View article]
    Brake out the chainsaw it sounds like-
    Apr 11, 2013. 12:32 PM | Likes Like |Link to Comment
  • Where Is Pfizer Heading With The Patent Cliff? [View article]
    Oh what a tangled web we weave
    When first we practice to deceive. - Sir Walter Scott (Marmion, 1808)
    Apr 11, 2013. 12:29 PM | Likes Like |Link to Comment
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