Greg Parker

Biotech, long only, healthcare, dividend growth investing
Greg Parker
Biotech, long only, healthcare, dividend growth investing
Contributor since: 2009
Form 4 filed with SEC on 07/08/2015. He received direct ownership of 150,000 shares, not options. They are exercised. You can go to EDGAR and look yourself. I'm not suggesting he paid for them out of his own pocket.
Their new CFO, Richard Slansky, picked up 150,000 shares last week at $6.12, now owning ~$0.9M worth of stock. This was the maximum that he was given the option to purchase. Seems like a bullish signal to me. I sold out of my initial ONCS position for a modest profit a while back, though decided to buy back in and am still underwater, though only a very small position. I'll let it run.
Great article, I actually wrote a similar piece over the weekend, though it was not accepted by the SA editors - I wasn't quite as politically correct in addressing the recent laughable short articles as you were. Keep up the good work! I'm expecting a ten bagger on this one, long CTIX @$1.80
Nice article, thanks for sharing. Long CLDX since $3.95, not planning to sell anytime soon.
Very surprised that CTIX didn't make the cut. Given how much Merck paid for Cubist to get their hands on Daptomycin, further positive results for the more effective Brilacidin should propel the stock price to $10+. (Disclosure: Long CTIX)
Another interesting angle to consider is the combination therapy of Copaxone with Trimesta which is currently in Phase II trials. One could envision a scenario where TEVA purchases Synthetic Biologics (SYN) as a means to extend the life of Copaxone with additional patent protection. I like the odds either way.
Disclosure - I am long both TEVA and SYN.
Nice article. Long CLDX ($3.95)
Great article, my sentiments exactly. As a Brit I always appreciate a good Churchill quote, here's a couple of others you might enjoy.
"Socialism is a philosophy of failure, the creed of ignorance, and the gospel of envy, its inherent virtue is the equal sharing of misery."
"An appeaser is one who feeds a crocodile, hoping it will eat him last"
I am not actually the author of the post, just a stockholder of AMRN who stumbled upon the article.
nz2 - If you checked your facts more carefully you would know that AMR101 is being investigated for several related indications. While some phase III trials have been completed, and the NDA filed for patients with high triglyceride levels, another Phase III trial to study its ability to reduce cardiovascular disease (REDUCE-IT) is only just beginning.
Nice article! I hold FRD and also believe it to be undervalued.
Sorry Justin, I was just trying to point out a simple error to help make your future postings more technically accurate. It seems however, that my comment was not received in the constructive manner in which I intended it.
I am pleased to see articles related to smaller biotech and pharma companies, however your lack of chemical training exposes you. You have sent me source links that agree with exactly what I wrote in my previous comment! You refer to the racemic d,l-mixture of leucovorin as "the inactive isomer", this quite simply is not correct. The mixture, by its very nature contains both inactive (dextro, d-) and active (levo, l-) isomers in equal parts. Aside from the mixture, the inactive d-isomer (dextroleucovorin) is not commercially available in the US.
SPPI are simply working on the active (levo, l-) isomer and comparing it to the currently marketed racemic mixture (leucovorin) which contains BOTH isomers (active, l- and inactive, d-). It is a common pharmaceutical strategy when the mixture is off patent for a company to try to market whichever isomer contained within the mixture is the active one, as this offers the potential to patent the single isomer, even after the mixture is off patent.
On Jun 20 11:42 PM Justin M. Hall wrote:
> Greg Parker:
> Thanks for the feedback. Regarding the inactive isomer, please consider
> checking out the information at the following links pasted below.
> It might also help if you go to SPPI's website and listen to the
> webcast, which I cited as the primary source for the information
> provided.
> annonc.oxfordjournals....
Thanks for your article. It's refreshing to read articles related to the biotech/pharma sector from someone knowledgeable in how drug development actually works.
Thank you for your article. I have no comment to make regarding your motivations for putting SPPI into the spotlight, but clearly you are not really familiar with the drug compounds involved. The currently prescribed generic leucovorin is not an inactive isomer as you say, if it were inactive, why would they sell it?! It is simply a 1:1 mixture of levoleucovorin (active) and dextroleucovorin, which are both isomers of leucovorin (5-formyltetrahydrofol... Levo- and dextro- are simply descriptors as to how the molecule is arranged in space, a similar analogy is saying left or right handed. Generic, refers to the fact that the compound is off-patent, allowing other companies to compete with the brand name drug, it makes no reference to the isomeric form of the compound.
In the past, the FDA allowed companies to market isomeric mixtures fairly readily which is why it is common to find older generic drugs are in fact mixtures like this. More recently, the FDA has required a much more rigorous testing of each isomer, particularly in the light of what happened with thalidomide, where only one isomer was responsible for the toxic effects. From a chemical standpoint, it is often easier to synthesize and isolate the mixture, so that is how it was usually done in the past. Modern synthetic techniques have made it much easier to target the single isomers, which is what SPPI have done.
Also, it may be true that the total dose of leucovorin is reduced by half in the SPPI formulation, but all they have really done is remove the dextroleucovorin from the mixture. The amount of the active levoleucovorin remains the same.
The author writes:
"While the generic version currently prescribed to patients in the US is an inactive isomer, Fusilev is a pure active isomer of leucovorin.
Pure Isomer (Fusilev) v. Inactive Isomer (generic leucovorin): The inactive isomer tends to compete with the active isomer and leads to more variability of biological outcome. This means, patients tend to react to the inactive isomer version (generic leucovorin) with more variability. Such variability is not as noticeable in the pure isomer version (Fusilev).
Head to Head Study: A study comparing equivalent doses of Fusilev and generic leucovorin indicated there was a statistically significant reduction in toxicity with Fusilev. The results showed there was nearly a complete reduction in severe grade 3 and 4 toxicities in patients treated with Fusilev. It is worth pointing out that Fusilev is prescribed in 250 mg doses, half that of generic leucovorin."
I am surprised to see that Yanzhou Coal didn't make the cut. The company has low debt, has shown excellent growth in recent years, and pays a healthy 4.2% dividend.
See related article:
Thank you for your comments. Just to clarify - I have no position in SPRO - as my disclosure clearly states at the bottom of the article.
While I do like the company, and will continue to keep a watch on it, the lack of liquidity is not something I feel comfortable with at this point. I will continue to write about smallcap companies that I believe represent potential investment opportunities, particularly value stocks and those that are not receiving a lot of coverage elsewhere. My aim when writing is simply to present ideas for further investigation, you should always do you own research before investing, no matter who may be recommending something to you. You are, of course, free to take what I write and do with it as you please, I always disclose my positions in my articles.
Thanks again for reading.
Wisdom vs. information makes two very good points here. It would appear from the most recent quarterly filing that Image Sensing Solutions gets around 25% of their revenue from direct sales within the US, around 25% from direct sales outside of the US, and the remainder as royalties from licensing their technology. The Autoscope product line is licensed to Econolite, an industry leader in traffic management systems, a partnership resulting in over 50,000 cameras deployed in over 55 countries and most North American cities. I believe that it is quite likely that Econolite would benefit from the federal stimulus, which indirectly would benefit ISS through increased royalties.
I'm a big fan of Air T (AIRT) also. Great fundamentals and a nice dividend. Just the kind of stock Warren Buffett would love, if only he could buy shares in such a small company.
The stock ticker CCF belongs to Chase Corporation, a manufacturer of sealants and laminates and not to Chase bank as the article link implies. I believe the ticker you are looking for is JPM
A good, thought-provoking article. A quick scan through all the comments reveals that there really are still a lot of unknowns in the financial sector, and that everyone creates their own suppositions based on what they believe the lack of information truly means.
For example, one could argue that the lack of information regarding off balance sheet assets must mean that there are huge losses hiding, because if there was any good news then they would've told us already. This enables them to possibly off load some of it to investors who aren't entirely sure what they are actually buying! You could also just as easily argue that the lack of information means that banks are still making decent income from these assets and they are not ready to give them up at firesale prices.
My gut feeling is that the former is closer to the truth, although it probably isn't quite that clear cut. I that if we knew more of what goes on behind the scenes and off the balance sheets at many banks, then the markets would fall much more than we have already witnessed, but that may just be due to a lack of understanding.
The government and the media seem to be painting an overly optimistic picture of the current economic environment, saying that the worst is over and that the Federal Reserve has everything under control. I don't think we could be further from the truth, as two further bubbles are readying themselves to pop.
I fear a collapse in the treasury market along with a strong possibility that the US will have to default on its debts, as they cannot keep on printing money indefinitely. And I fear a further collapse in the banking industry fueled by delinquencies of consumer credit cards.
Credit card companies have been seen to be raising interest rates, cutting credit lines, and closing inactive accounts. This serves to reduce consumer spending and confidence, and is a self-feeding cycle as it leads to reduced FICO scores, leading to reduced access to credit which in turn causes a further reduction in spending, hurting the economy further in the process.
You state in your article that this is not really an issue, however, it depends on the consumer. With the level of unemployment still rising, we are seeing more and more people using credit just to survive and make essential purchases. People have already cut back significantly on large purchases such as houses, cars and vacations, they have also cut back on luxuries, electronics and the like. People are now relying on credit for essential, day to day purchases such as food, clothing and energy. Now, I don't know about you but I find this scary! Credit card companies have been reporting increasing numbers of delinquencies, and I fear the worst is still to come.
Disclosure - Author holds positions in TBT and FAZ.
Nice article, I couldn't agree more.
Everybody likes to point their fingers at the government, or blame the banks for the economic mess that we currently find ourselves in, but maybe we as consumers have helped facilitate things more than most of us like to admit. Everybody likes to accuse the banks of being greedy, but ultimately they are in the business to make money for themselves and their shareholders, not to be charitable to the general public.
We are all grown adults, and those of us that have made poor financial choices should take responsibility for them, learn from them, and move on. I am not pointing fingers at everyone, as we are left with a situation where those of us that were responsible with our finances, and made "smart" choices, are the people having to bail out the irresponsible and greedy! I am also not supporting some of the banks actions - they were irresponsible and reckless at times. I believe that if we knew more of what went on behind the scenes and off the balance sheets at many banks, then the markets would fall much more than we have already witnessed, but I do think we as consumers need to take part of the responsibility.
The worrying thing is that with the level of unemployment still rising, we are seeing more and more people using credit just to survive and make essential purchases. People have already cut back significantly on large purchases and luxuries and are yet are still forced to rely on credit to pay for food, clothing, energy and healthcare. I think the ride is far from being over...
I don't see any reason to believe that this is the bottom, or that the bottom is anywhere close. Unemployment numbers continue to get worse, there doesn't appear to be any significant improvement in the housing market, the Fed is printing money at an incredible pace while trying to obtain even more powers than it already has.
It is unreasonable to believe that the government can bail out all of the fallen giants without further repercussions. The latest plan appears to amount to little more than moving the toxins further up the economic food chain. Ultimately I fear a total collapse in the treasury market despite the FOMC's attempt to prop it up, as the Chinese and Japanese refuse to continue to fund the Fed's wild spending spree.
Disclosure - At the time of writing the author held positions in FAZ and TBT
Nice article, and spot on with the movie clip. I totally agree that we've not seen the end of the downside. There's still a lot of negatives that need to work their way through the system before we can experience a LASTING rally. I'm sure we'll see several bear market rallies as we resume the slide into negative territory.
The banking sector still has fundamental flaws in its business model, which will take time to correct. Added to which, the huge level of US debt is in danger of causing a collapse in the treasury market, particularly if countries such as China and Japan do not continue to purchase as much US debt in the future as in years past.
Disclosure - At the time of writing the author held positions in FAZ and TBT.
An interesting article. Another thought to consider is this.
With the Chinese government having the world's largest holding of US treasuries and continually expressing their discontent over the devaluing nature of the US government's activities toward their investment, and the Federal Reserve announcing plans to purchase long term treasuries in the days to come. I believe it is quite likely that they will purchase some of those directly from China as a means of appeasing them a little, rather than buying just freshly created ones. This also reduces the inflationary risk of their actions. This in turn carries with it the implication that the Chinese will not be purchasing many more new treasuries from the US in the near future, heightening the risk of a collapse in the treasury market.
Disclosure - At the time of writing the author held a position in TBT, and is bullish on oil, gold and commodities.
While very few can argue about the weakness of the US dollar, I believe that China is in no place to provide a suitable replacement currency, and the Eurozone even less so. Rather than arguing for a new reserve currency, they are probably best to make a push to devalue the yuan in order to stimulate their own economy.
With the FOMC announcing plans to purchase treasuries, there is a good possibility that they will be purchasing some existing ones from the Chinese, rather than just freshly created ones, in order to appease them a little. All of which could ultimately lead to a collapse of the treasury market.
Disclosure: At the time of writing the author held a position in TBT.
Yes, totally agree. Stem cell research may well be the bubble of 2009 as weary investors try to make a quick buck to cover last years losses. Clearly all hype and no evidence of profitability. Riding the "Obama wave"....
Stem cell research may prove to be the bubble of 2009 as weary investors try to recoup some of their heavy losses from 2008. Clearly investors are riding the "Obama wave", STEM and GERN are all hype with no evidence of profitability.
Stem cell bubble