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A researcher into gene silencing as a technology for improving the lives of those suffering from incurable diseases. Benitec Biopharma is my primary investment in this technology as ddRNAi offers one-time treatments for a broad range of these diseases.
  • Business Case For Hep C Treatment 2 comments
    Feb 18, 2014 11:12 AM | about stocks: BNIKF, GILD

    In trying to convince investors and potential partners to put money into the development of Benitec's (OTCPK:BNIKF) treatment for Hepatitis C (HCV), TT-034, management no doubt had to produce some kind of business plan. This draft report by the Institute for Clinical and Economic Review in California provides Benitec's management with some powerful information with which to demonstrate how TT-034 will be able to compete with the newer HCV drugs that are coming on to the market. This information should support Benitec business case for TT-034 handsomely.

    The report estimates the possible cost of the new treatments to be worth between $18-29 billion in California alone. Furthermore, it goes on to say that even after twenty years the cost offsets in the community will only recover about 66% of the initial costs. The cost for these new drugs is therefore unsustainably high.

    Unlike it's competitor Gilead (NASDAQ:GILD), Benitec has not had to pay $11B for its HCV treatment and so there is every chance that TT-034 could undercut Gilead's sofosbuvir in the marketplace. It is clear from this analysis that, if TT034's clinical trial goes well and Benitec gets the pricing right, TT-034 will be a very profitable drug and will provide significant returns for shareholders.

    A successful TT-034 stands a very good chance of becoming the standard of care for HCV.

    The Executive Summary says:

    The clinical advantages of newer treatment regimens would therefore come with a substantial potential impact on health care budgets should a large number of patients be treated. As estimated by our model, we anticipate cumulative one-year treatment costs per 1,000 patients to be somewhere between $100-$200 million. For example, if a risk-bearing integrated provider group is responsible for the care of 500,000 patients, and one assumes an underlying infection rate of 1.7 %, there would be approximately 8,500 patients in this population infected with Hepatitis C. If e even 50% of this population comes forward for treatment, the immediate one-year budget impact for the provider group would be estimated to be over $400M. It would be impossible for this magnitude of immediate increased spending to be accommodated within the budgets established by current health care premium structures, provider risk-sharing contracts, and patient co-payments.

    Using an estimate of the number of infected individuals in California who know of their infection and would be considered for treatment, we estimate that replacing current care with sofosbuvir-based regimens would raise drug expenditures by $18-$29 billion in a single year. We looked for potential cost offsets to these initial costs of drug treatment that could result from downstream reductions in liver-related complications following successful treatment of hepatitis C infection. At a 5-year time horizon, however, cost offsets would be estimated to represent less than 10-20% of upfront treatment costs. Even at a 20-year horizon, if all patients infected with hepatitis C are treated with new regimens, the cost offset will only cover approximately two-thirds of initial drug costs.

    Disclosure: I am long BNIKF.

    Stocks: BNIKF, GILD
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  • Tile
    , contributor
    Comments (120) | Send Message
    $GILD will have no other choice than to double the $11 billion paid to acquire Pharmaset to swallow $BNIKF.
    18 Feb 2014, 11:47 AM Reply Like
  • Pannobhaso
    , contributor
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    Author’s reply » Another article which lends weight to the argument that the new HCV treatments will not be the end of the HCV treatment story. As Benitec anticipates, there will still be a sizable market for TT-034 once it is validated in the clinic.


    The New England Journal of Medicine says:


    "It may now be possible to imagine the global eradication of HCV infection, but three major challenges remain. First, in the absence of effective screening programs, HCV infection is often diagnosed at a late stage (in high-income countries) or seldom diagnosed at all (in low- or middle-income countries). Second, the high cost of DAAs will preclude their use in most infected patients in low- or middle-income countries; in high-income countries, the need for payers to provide major resources for HCV treatment may lead to the selective use of DAAs for certain patient subgroups. Third, reinfection remains possible even after successful curative therapy.


    Ultimately, a preventive vaccine would be desirable for the global eradication of HCV, but the virus's extraordinary sequence heterogeneity and ability to evade host immune responses pose challenges for the development of a broadly protective vaccine. In the meantime, effective HCV screening programs, including full implementation of birth-cohort screening in the United States, the establishment of access to affordable treatment in low- and middle-income countries, and strategies for reducing the risk of transmission (e.g., safe injection practices) will probably be needed to control HCV infection on a global scale. The introduction of DAAs represents a major breakthrough, but it is only a first step toward eliminating HCV globally."



    Please this in conjunction with the original SA Instablog above.
    1 May 2014, 11:58 AM Reply Like
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