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  • Progress In The Development Of VistaGen's (VSTA) AV-101 Prodrug Candidate For Treating Neuropathic Pain And Depression 0 comments
    Nov 22, 2013 1:56 PM | about stocks: VTGN

    With grant funding from the U.S. National Institutes of Health (NIH), biotechnology company VistaGen Therapeutics, Inc. has successfully completed Phase 1 development of AV-101, an orally available small molecule prodrug candidate. AV-101 is targeted at the multibillion-dollar neurological disease and disorder market, including depression and neuropathic pain, which is a serious and chronic condition that causes pain after an injury or disease of the peripheral or central nervous system. In support of the company's nonclinical and Phase 1 clinical development of AV-101, the NIH awarded VistaGen more than $8.8 million in grant funding.

    Also known as "L-4-chlorokynurenine" and "4-CI-KYN," AV-101 is converted in the brain into 7-chlorokynurenic acid (7-CI-KYNA), an active metabolite and an agonist of the N-methyl-D-aspartate (NMDA) receptors. One of the most potent and selective blockers of the regulatory GlyB-site of the NMDA receptor, 7-CI-KYNA is a synthetic analog of kynurenic acid, which is a naturally occurring CNS regulatory compound.

    AV-101 demonstrated very good levels of oral bioavailability in preclinical studies, as well as rapid and efficient transport across the blood-brain barrier and preferential conversion into 7-CI-KYNA at the site of seizures and potential neural damage in the brain and spinal cord.

    VistaGen believes the safety studies completed in its AV-101 Phase 1 program may enable Phase 2 development of the drug for both neuropathic pain and depression. AV-101 has the potential to treat other neurological conditions, as well.

    For more information, visit vistagen.com

    QualityStocks provides investor relations services to publicly traded companies in exchange for compensation. This article may be part of our efforts to widen a client's exposure. To read our full disclaimer, visit http://disclaimer.qualitystocks.net

    Stocks: VTGN
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