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  • Eicosapentaenoic Acid Induces Rapid Regression Of Atherosclerosis 0 comments
    Sep 14, 2013 6:30 PM | about stocks: AMRN

    Via Modulating the Phenotype of Dendritic Cells in LDL Receptor-Deficient Mice... In Arteriosclerosis, Thrombosis and Vascular Biology 2011;31:1963-1972. So claim the researchers at Kobe and Kyoto Universities in Japan. atvb.ahajournals.org/content/31/9/1963.full.pdf+html

    Let's take a look at another study that has demonstrated the beneficial therapeutic effect of EPA. To start,

    "LDL-receptor-deficient mice were fed a high-cholesterol diet for 8 weeks to build up aortic sinus atherosclerotic lesions and then were fed a normal diet with or without 5% EPA for 4 weeks."

    Then they analyzed the results,

    Atherosclerotic lesions were histologically assessed, and immunologic assays were performed.

    They demonstrated,

    "that EPA treatment results in rapid regression of atherosclerosis, supporting the clinical beneficial effects of EPA on secondary prevention of cardiovascular diseases in patients. Transfer of high-fat and cholesterol-fed LDLR -/- mice to a normal diet stopped further progression of atherosclerosis and led to a less inflammatory plaque phenotype, but it was not sufficient to induce the regression of aortic sinus lesions.

    In contrast, a marked reduction in aortic plaque area was found in EPA-treated mice, suggesting that EPA facilitated the net removal of inflammatory cells and lipids probably due to antiinflammatory actions and increase in reverse cholesterol. In the present study, we demonstrated that the number of infiltrated cells and mRNA expression of several chemokines, cytokines and adhesion molecules were significantly reduced in atherosclerotic lesions in EPA-treated mice."

    Here is a visual representation of their findings,

    (click to enlarge)

    And in conclusion they say,

    "Atherosclerotic plaque regression should represent a therapeutic goal in the management of ischemic heart disease."

    I would have to agree.

    Disclosure: I am long AMRN.

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