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  • Swine Flu, MERS, Ebola And Medical News Concentrator June 7, 2014 To August 16, 2014 450 comments
    Jun 7, 2014 11:11 AM

    This instablog is designed as an interactive News Concentrator devoted to news and discussions about Swine Flu and other medical news.

    The top portion of the instablog contains useful background information/ charts.

    Up-to-date news content is posed in the comments area. So if you are interested in current news, read the comments.

    _____________________

    Some Definitions:

    What is Reassortment

    When two different virus strains infect the same host, they often exchange genes, a process known as reassortment.

    A significant number of experts are concerned that as H5N1 (Avian Flu) spreads more widely and infects more people, it will come across more hosts who are also carrying human flu viruses. This increases the likelihood of a new strain emerging that has the severity of the bird flu virus and the infection rate of the swine flu virus, leading to a new global pandemic with much deadlier consequences than the one we are experiencing at the moment.

    What is R naught (R 0)

    How many people the average infected person infects is called the basic reproductive number, or R0 (pronounced "R naught").

    Measles, which is probably mankind's most contagious infection, has an R0 of about 18. Polio's number is about 6; severe acute respiratory syndrome (SARS) about 5. For seasonal flu strains, the R0 is about 1.2, and for pandemic strains it is rarely higher than 2. For the novel H1N1 strain, it's about 1.6. What this low R0 means is that flu outbreaks are always teetering on the verge of having their myriad chains of transmission broken by people who get infected but don't pass the virus to anyone else.

    Swine Flu - Novel H1N1 flu, popularly known as swine flu, is a respiratory infection caused by an influenza virus first recognized in spring 2009. The new virus, which is officially called swine influenza A (H1N1), contains genetic material from human, swine and avian flu viruses. (By Mayo Clinic staff)

    Pandemic - The word "pandemic" comes from the Greek "pan-", "all" + "demos", "people or population" = "pandemos" = "all the people." A pandemic affects all (nearly all) of the people.

    A World Health Organization phase 6 pandemic indicates that influenza due to the novel H1N1 swine flu is occurring in multiple countries around the world and that human infection is widespread. The classification does not reflect the severity of individual infections.

    Cytokine Storm -
    When our body detects foreign micro-organisms indicating an infection, our body might respond by over-protecting the site of infection. The body may race so many antibodies to the infection site that they collect in what is known as a cytokine storm.

    A cytokine storm, or "Hypercytokinemia" is a potentially fatal immune reaction consisting of a positive feedback loop between cytokines and immune cells.
    www.wisegeek.com/what-is-the-cytokine-st...

    A positive feedback loop means that as something increases, that increase stimulates further growth.

    What makes younger people more susceptible to H1N1 is that their "vigorous immune systems pour out antibodies to attack the new virus. That can inflame lung cells until they leak fluid, which can overwhelm the lungs.

    This vulnerability in the young is reminiscent of the Spanish flu of 1918. That strain of flu also struck mostly healthy young adults.

    Pulmonary Embolism - Occurs when a blood clot forms in an arm or leg breaks free and enters the lungs where it is too large to pass through the small vessels of the lungs and forms a blockage. This stops blood from flowing into an area of the lung, and the part of the lung dies because it does not receive oxygen.
    medicalnewstoday.com/articles/153796.php

    What is an Emergency Use Authorization (EUA)?
    An EUA may be issued by the Food and Drug Administration (FDA) to allow either the use of an unapproved medical product or an unapproved use of an approved medical product during certain types of emergencies with specified agents.

    What is the PREP Act?
    The PREP Act authorizes the Secretary of the Department of Health and Human Services ("Secretary") to issue a declaration ("PREP Act declaration") that provides immunity from tort liability (except for willful misconduct) for claims of loss caused, arising out of, relating to, or resulting from administration or use of countermeasures to diseases, threats and conditions determined by the Secretary to constitute a present, or credible risk of a future public health emergency to entities and individuals involved in the development, manufacture, testing, distribution, administration, and use of such countermeasures.

    The PREP Act also authorizes an emergency fund in the United States Treasury to provide compensation for injuries directly caused by administration or use of a countermeasure covered by the Secretary's declaration. While no funds have been appropriated for this purpose, if funds are appropriated, compensation may then be available for medical benefits, lost wages and death benefits to individuals for specified injuries.
    cdc.gov/h1n1flu/eua/qa.htm

    What are Clinical Trials:
    Clinical trials, also known as clinical studies, are research studies in which scientists and doctors test new drugs and treatments to see if they will improve health. Many of today's treatments for cancer are based on the results of past clinical trials. Because of progress made through clinical trials, many people treated for cancer are now living longer.

    Clinical trials are divided into four phases.
    Phase 1 trials: These trials are the first time a new drug or treatment is given to humans. They are normally carried out in a small number of volunteers (typically 6-20 people) who may include healthy volunteers or patients with the disease for which the product is intended as a treatment in order to find out how safe the treatment is. They also look at how a new drug should be given (by mouth, injected into muscle or the bloodstream, etc.), how often and at what dose. Phase 1 trials can also involve patients for whom standard therapies have failed and for whom no other therapies are available.

    Phase 2 trials: These trials involve larger numbers of people (typically 12 - 50). Phase 2 trials continue to look at safety of the therapy but also test how well the new drug or treatment works in patients with different disease types.

    Phase 3 trials: These are large studies (100+ people) that look at how well a new drug or treatment works in comparison to current therapies to see which treatment is better. Those taking part are usually divided into two treatment groups: standard treatment versus new treatment.

    Phase 4 trials: These trials are usually carried out after the drug or treatment has been approved by the FDA and is readily available for use in the general patient population. The purpose of Phase 4 trials is to continue to study the effects of the drug or treatment on different populations and to look for side effects associated with long-term use.
    Back to Top

    What is a Protocol:
    Clinical trials use written guidelines called protocols. The protocol explains what the trial hopes to accomplish, how the trial will be carried out, and why each part of the trial is necessary. For example, the protocol includes:

    * The reason for doing the trial
    * How many people will be in the trial
    * Who is eligible to take part in the trial
    * What study drugs participants will need to take
    * What medical tests participants will have and how often
    * What information will be gathered

    Every doctor or research center that takes part in the trial uses the same protocol. This makes sure that patients are treated identically no matter where they are receiving treatment, and that information from all the centers taking part can be combined and compared.

    Why Slow Production for Traditionally Produced (chicken eggs) Swine Flu Vaccine:
    One dose of swine flu vaccine for every two eggs, compared with two doses of
    seasonal flu vaccine per egg

    Sorry if the link does not work... it appears the Boston Globe newspaper appears to be playing games with link addresses... Just copy the link, and Google it.

    http://www.boston.com/business/healthcare/articles/2009/10/22/quest_for_swine_flu_vaccine_giving_some_firms_a_boost/

    _____________________
    Brief Overview of Categories of H1N1/ Vaccine Investment Plays:

    I - Vaccines / Prevention
    1) Production Method / Capacity plays (NASDAQ:NVAX) (NASDAQ:VICL) (NYSE:NVS) (NASDAQ:INO) (NYSE:CSL)
    2) Nationalistic / Population Size Play (SVA - China) (NVAX - India)
    3) Injection / Vaccine support services (syringes etc.) (NYSE:BAX) (NYSE:BDX)
    4) Outsourced production plays
    5) Bio -Defense (MDCGF - France)
    6) Anti-Mutation / Pan-Influenza Play (NYSEMKT:CVM) (NYSEMKT:NNVC) (INO)
    7) Universal Flu Vaccine Play (INO)

    II - Treatment After Infection Occurs:
    1) Dealing with severe lung infections (Fludase® (DAS181)) (NYSE:CBM) (OTCQB:OTCQB:OTCQB:AEMD)
    2) ICU treatments (NASDAQ:BCRX) (NYSE:GSK) (NYSE:ROG)
    III - Population Avoidance:
    1) masks/ disinfectants… Surgical masks are good enough (NYSEMKT:APT) (NYSE:MMM) (NYSE:CLX) (NYSE:ECL) (OTCQB:OTCQB:OTCQB:OTCQB:PURE)

    IV - Testing do you have it? (NASDAQ:GPRO)
    1) Test kits - (NYSE:DGX)

    V - Merger / Acquisitions / Licensing (VICL) (NVAX)
    _____________________
    Sorry this is still a graphic instead of a table. I played with the table tool, but its a
    PITA to work with.

    Swine Flu Companies Discussed and Their Web Sites

    _____________________
    Swine Flu Hits Stuffed Animal World:

    Link to 2011 H1N1 US Flu Outbreak Map is broken... sorry.

    Red Cross Tips For Dealing With The Flu:

    IF YOU ARE ILL -
    * Stay in a room separate from common areas of the home and avoid contact with others as much as possible.

    * Stay at home for at least 24 hours after their fever is gone without using medicine to reduce the fever.

    * Get lots of rest and drink plenty of fluids.

    * Consider wearing a face mask, if available and tolerable, when sharing common spaces with household members. (ed - surgical masks ok).

    * Check with your healthcare provider about whether to take antiviral medication, or if fever persists, whether antibiotics are needed.

    WHEN CARING FOR SOMEONE WHO HAS THE FLU -
    *Disinfect door knobs, switches, handles, toys and other surfaces that everyone touches.

    * Use detergent and very hot water to do dishes and wash clothes. It's okay to wash everyone's dishes and clothes together. Wash your hands after handling dirty laundry.

    * Designate only one adult as the caregiver. People at increased risk of severe illness from the flu should not be caregivers.

    * Although not mentioned by the Red Cross, the caregiver should probably ware a surgical mask as well when entering the sick room.

    * Deal with crisis situations calmly and confidently to give the best support to the person being cared for.
    _____________________

    MayoClinic.com Provides Credible, Up-to-Date Information And Decision-Support Tools For Flu Season

    Click here to link to the Mayo tool:
    www.mayoclinic.com/health/flu-symptoms/F...

    _____________________
    Suggested Protocol For Schools To Decide When Flu Should Trigger A Shutdown
    www.medicalnewstoday.com/articles/169984.php

    After comparing more than two dozen possible scenarios for closing a school, the analysis suggested three optimal scenarios:

    1. A single-day influenza-related absentee rate of 5 percent

    2. Absenteeism of 4 percent or more on two consecutive days

    3. Absenteeism of 3 percent or more on three consecutive days

    Disclosure: (sometimes trading, sometimes holding)

    Global Disease Outbreak Map

    Flu, Chikungunya, Dengue, MERS

    tinyurl.com/c8f3do

    Link from Guns and OG.

    2014 U.S. Ebola Outbreak Map and Information tinyurl.com/ll4deyw

    DoubleGuns sent us this link... Thank you Guns!

    Disclosure: I am long FTEK.

    Additional disclosure: I move in and out of Bio-Tech stocks all the time. In other words, I take profits from time to time. Of course, I also take loses…

Back To FocalPoint Analytics' Instablog HomePage »

Instablogs are blogs which are instantly set up and networked within the Seeking Alpha community. Instablog posts are not selected, edited or screened by Seeking Alpha editors, in contrast to contributors' articles.

Comments (450)
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  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » Link to old concentrator: http://tinyurl.com/mqy...
    7 Jun 2014, 11:17 AM Reply Like
  • H. T. Love
    , contributor
    Comments (19491) | Send Message
     
    There is no "old concentrator", just gracefully aged prior concentrators! :--)

     

    Thanks Rattie!

     

    HardToLove
    7 Jun 2014, 11:29 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Here's to us- there's nobody better-
    Except for Rattie- He's better than the rest!

     

    Thanks for the new bigger and better concentrator, Rattie!

     

    WT
    7 Jun 2014, 04:48 PM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    Where else can we possibly get a concentrated daily dose of flu horrors!?

     

    Cheers, Ratso, and long may you scuttle through the back allies of deadly viruses!
    7 Jun 2014, 05:52 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    I never get sick of learning about virus investments that can go viral.

     

    Thanks, FPA!

     

    Kind of a bifurcated feeling, is investing in Novavax and Stellar. Sure, in my own little way, I'm investing in ideas that can save humanity. But before all that, a lot of humans would likely have to perish. It's unsettling to me that the greater number of humans that die from some terrible virus, the greater chance I have to make some money.

     

    In effect, I'm hedging against humans dying in great numbers.

     

    Now that's quite the House of Horrors!
    7 Jun 2014, 07:37 PM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Missed another one,

     

    Merck to buy Idenix for $24.50 per share
    9 Jun 2014, 08:00 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    NVAX files form for new issue

     

    If all you had to go on was this ... we would never buy it. I never seen so many warnings across all business aspects.
    9 Jun 2014, 09:01 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    PRINCETON, N.J., June 9, 2014 (GLOBE NEWSWIRE) -- Advaxis, Inc. (Nasdaq:ADXS), a biotechnology company developing cancer immunotherapies, announces that its management team will host a corporate business update conference call to review recent Company events, data presented at ASCO, immunotherapy industry developments and the Company's business strategy. The call will occur on Tuesday, June 10, 2014, beginning at 10:00 am EDT.
    9 Jun 2014, 09:07 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    (NVAX( up 6% to $4.42
    9 Jun 2014, 10:33 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Inovio Pharmaceuticals Could Outperform - Dr. J. Joseph Kim, CEO, Tells Us Why
    http://seekingalpha.co...
    9 Jun 2014, 11:34 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Re:(NVAX)

     

    Bought in my Short position in NVAX $6.00 October Calls for a 44% gain.
    It will most certainly be choppy but I feel NVAX is headed much higher.

     

    WT
    9 Jun 2014, 12:13 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    WT: Great move. Hoping I'm wrong, but I expect there's going to be somewhat of a limiting to the upside "lid" on NVAX, with possibly as many 25M+ plus shares being issued at $4.00 soon coming.

     

    But so far I'm happy I got back in on Friday. I think $4.14 - $4.19 is a solid price and will hold from here on.

     

    My broker and I discussed some options with NVAX on Friday. I could tell he was beyond very interested in selling some puts, as well as some future calls.
    9 Jun 2014, 12:49 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    >Maya-

     

    Thanks-

     

    This from the NY Times on Ebola multiplying its victims dramatically-

     

    http://nyti.ms/1oO2ix7

     

    WT
    9 Jun 2014, 04:21 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    WT: Yes, following eboli. 90% death rate is alarming.

     

    Seems a lot of the more exotic travel destinations this year are experiencing outbreaks of one kind or another.

     

    Even gorgeous Phuket is having an outbreak of dengue.

     

    Lets just hope nothing is going on in Brazil, with all the World Cup international travel that's going to happen over the next few (exciting) weeks.
    9 Jun 2014, 04:44 PM Reply Like
  • doubleguns
    , contributor
    Comments (9693) | Send Message
     
    Maya, What happens in Brazil should stay in Brazil. Unfortunately that may not be the case.

     

    http://fxn.ws/1pdDSRc

     

    From the link above. "Dengue, sometimes called breakbone fever because of the severe pain it can cause, is a viral infection transmitted by a type of mosquito called Aedes aegypti. It can range from a mild, flu-like illness to a potentially deadly one, which develops in around 5 percent of patients. There are no vaccines or effective treatments.

     

    Brazil has more cases of dengue fever than anywhere else in the world. More than 7 million infections were recorded between 2000 and 2013."

     

    I noticed that they call Dengue "Break bone Fever" which is what Native Americans used to call influenza so maybe the same herb they used for that would be good for Dengue. Just so you all have heard about it I have included some info on that. In case this gets rampant here.

     

    From the link below: "Before World War I Native Americans, having had many of their people stricken with influenza, were familiar with the disease. They did not call it influenza however. They called it "break bone fever". They called it break bone fever due to the incredibly painful sensation caused by influenza that produced the feeling of the bones being broken."

     

    "This was probably due to the severe tension and contraction of ligaments which, "when temporarily relaxed and in clonic (convulsive) spasms, produced the sensation that the bones were breaking".

     

    "Native Americans used boneset in the treatment of break-bone fever or influenza. They were such adepts at herbology that most herbalists recognize that if a Native American used or approved an herb the herb was efficacious."

     

    "Indeed the Native Americans were masters at the craft of herbology. In fact, one Native American in Colonial times became famous for curing typhoid with boneset. For decades thereafter boneset was named after him i.e., Joe Pye weed."

     

    Learn more at this link:http://bit.ly/1pdDSRg#
    9 Jun 2014, 05:47 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Great insights, guns!
    9 Jun 2014, 06:15 PM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Inovio Pharmaceuticals Initiates Immune Therapy Trial for Head & Neck Cancer Caused by HPV
    http://bit.ly/SuqrOk
    10 Jun 2014, 05:14 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    This is from yesterday....stock may still have room to run if the demand for Opiod dependence is as high as I think it is.

     

    BioDelivery Sciences set for gap up
    Shares of BioDelivery Sciences (BDSI) are set to jump past resistance at $10 at the open this morning. Shares are up 4% premarket to $10.40 on modest volume. Friday after the close the company announced the FDA approval of Bunavail, a treatment for opioid dependence.
    10 Jun 2014, 05:26 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Feuerstein strikes again :

     

    Inovio Pharma (NYSE: INO) is seeing mid-day weakness following reports from TheStreet's Adam Feuerstein that the company's CEO, Joseph Kim, is prepping investors for a drug study failure.
    Feuerstein said red flags are clear, including news the company pushed through shareholder vote approving a 1-for-4 reverse stock split on May 23, which went into effect on June 5. The biotech watcher also noted that Kim hinted at negative VGX-3100 study results in Monday's interview conducted by a Seeking Alpha contributor.
    Shares of INO are down 1.3% mid-day to $10.64.
    Copyright 2014, Street Insider News Provided by Acquire Media Corporation
    10 Jun 2014, 02:58 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Chikungunya Virus Spreads to South America

     

    http://bit.ly/1phqVpy

     

    Ut oh!

     

    -- A team of French and Brazilian researchers warn that chikungunya virus is poised to invade, and become epidemic in the Americas according to research published (in April) in the Journal of Virology.

     

    -- The risk of a “catastrophic” epidemic in the Americas is boosted by the FIFA World Cup… what with people coming in from near and from far, says corresponding author Ricardo Lourenco-de-Oliveira of the Instituto Oswaldo Cruz in Rio de Janeiro, Brazil. Brazil annually reports the highest incidence of dengue, a virus that is transmitted by Aedes aegypti and Aedes albopictus, the same mosquitoes that transmit chikungunya, he says.

     

    ####

     

    I've never heard of chikungunya before a couple of weeks ago. Now I'm reading, ...risk of catastrophic epidemic?

     

    Also, the 90 cases I reported above in Phuket wasn't dengue, it's chikungunya.
    10 Jun 2014, 06:36 PM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    Sheesh!

     

    I'm takin' a case of Off! with me and lotsa long sleeves when I go to cruise the Amazon in August!

     

    Anybody know where to get some contraband DDT? :-0
    10 Jun 2014, 07:08 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Well, gall dengue it...

     

    Doc, I did think of your upcoming fantastic (I'm jealous of) Amazon trip when I linked in the above.

     

    Advice is to make sure you have a very close weaved fabric for pants and shirts and socks. These Aedes aegypti have a nasty, long, needle-like proboscis, of which I have read scientists are studying with the idea of how to better syringes.

     

    In a pinch, I've read that dryer sheets, like Bounce, if you rub them all over your skin and clothing, works great at repelling mosquitoes. Cigars work well, too.

     

    You probably know more than I do, but I also have read that certain blood types mosquitoes go after more than other blood types.

     

    My Honduran archeologist pal says that the best way to keep mosquitoes away is to not take a shower. Let your body stink its stink, when there's a "skeeter" invasion.

     

    Definitely not a litmus test, but I'm a fan of the reality show Survivor, and what I have noticed over the 20 plus seasons is that right away contestants after landing in tropical conditions get the sh$t bit out of them, and after a week or so, the contestants stink so much, mosquito bites go way down.

     

    I also a month ago bought some mosquito repelling cargo pants from Cabella's. They have shirts and hats, too. New development in the clothing industry.
    11 Jun 2014, 01:51 AM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    Yeah those bug repellant clothes are a real boon for outdoorsy types. But you can actually do it yourself with any clothing you can wash.

     

    Buy permethrin concentrate from a veterinary supply co and add it to a washload of clothes, and you get the same effect of impregnating the fabric with a safe insecticide/repellant.

     

    Permethrin is safe for skin contact, as it gets broken down by skin enzymes before it can be absorbed.
    11 Jun 2014, 07:56 AM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    Actually, looking at buying some veterinary permethrin online, I found an even cheaper source specifically marketed for clothing:

     

    http://bit.ly/1qtR9T2

     

    In the past I used the veterinary stuff intended for spraying horses and kennels and dipping dogs (available on Amazon.com), but it tended to have a slight lingering petroleum solvent odor after drying. If this stuff from REI dries odorless, it would be a better bargain.

     

    edit: Looking a little deeper, the REI spray is only 0.5%, but the concentrates are usually 10% strength, and should be diluted. Maybe still the better bargain to buy the concentrate and dilute it in your own spray bottle, as I did in the past.
    11 Jun 2014, 10:28 AM Reply Like
  • D-inv
    , contributor
    Comments (4810) | Send Message
     
    "Permethrin is safe for skin contact, as it gets broken down by skin enzymes before it can be absorbed. "

     

    Thanks for that info, SM. My oldest grandchild attracts mosquitos like honey attracts flies. Among groups of five-ten people, she has been the sole target too many times to remember.
    11 Jun 2014, 10:29 AM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    It is also extremely useful for ticks and preventing Lyme disease, which is endemic in my neighborhood. I and my kids have had the classic rash more than once.

     

    Regular DEET does not repel ticks, but permethrin does, and kills them. You can mix a batch of concentrate and spray play areas outdoors to get rid of the ticks.
    11 Jun 2014, 10:55 AM Reply Like
  • D-inv
    , contributor
    Comments (4810) | Send Message
     
    The Sawyer Permethrin product is also available through Amazon (and apparently a bit less expensive than through REI).

     

    http://amzn.to/1kOTMPb
    11 Jun 2014, 11:47 AM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    I'm thinking the 13% concentrate on Amazon may be the best bargain, as a reviewer says it works fine for clothing and dries odorless.

     

    http://amzn.to/1kOWvrK

     

    My 14 yo daughter is going to Costa Rica and Panama this summer with Girl Scouts to "save turtles" and learn how to scuba dive. At one point she will stay in a shack on an island with the natives.

     

    Then in August, with all three kids, a niece and nephew, and my Pop, we go to Peru to the Amazon.

     

    That's a lot of jeans and shirts and hats to treat.
    11 Jun 2014, 12:12 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Doc: I sure am glad this conversation came up...for you and yours.

     

    Another thing to consider is getting some shin- high rubber boots. Not fashionable, but will stop a snake bite. Years ago, Honduran farmers or coffee pickers didn't have them. Now they are ubiquitous as machetes.
    11 Jun 2014, 12:36 PM Reply Like
  • Mercy Jimenez
    , contributor
    Comments (2710) | Send Message
     
    Yes very glad to see this thread on Permethrin, Doc. I will need to check it out.

     

    I will differ with Maya, however, that mosquitos only hate "stink." I accidentally discovered that when I mix my sunscreen with lavender oil or just spray lavender water on me -- mosquitos leave me alone! Yes I know -- it's not a scientific medical trial -- but it seems to work for me and I smell better than Maya's method. LOL
    mj
    11 Jun 2014, 01:27 PM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    Thanks, folks.

     

    And yes, I have a good pair of leather waterproof high boots, that I imagine I shall pack along, now that you mention it.

     

    Most of the time we shall be on a riverboat (http://bit.ly/SzATnD), but I expect we shall be hiking occasionally.
    11 Jun 2014, 01:47 PM Reply Like
  • D-inv
    , contributor
    Comments (4810) | Send Message
     
    " I accidentally discovered that when I mix my sunscreen with lavender oil or just spray lavender water on me -- mosquitos leave me alone!"

     

    Thanks for the info, MJ. Will share with my family members.
    11 Jun 2014, 10:54 PM Reply Like
  • doubleguns
    , contributor
    Comments (9693) | Send Message
     
    Doc look at cedarcide too. Another natural mosquito repellent. It's what I carried to Honduras. You will smell like cedar however.

     

    I tried the Permethrin repellent hats before in Iceland where the mosquitoes and other biting insects travel in squadrons. It did not work. I am taking cedarcide this time and 100% deet (yuk) as a backup. You can get cedarcide in various quantities at amazon too.

     

    http://amzn.to/1irTbhy
    12 Jun 2014, 05:44 PM Reply Like
  • D-inv
    , contributor
    Comments (4810) | Send Message
     
    My daughter reports that lavender oil and spray are ineffective for the granddaughter. Mosquitos still swarm her (but she had not tried mixing with sunblock).
    12 Jun 2014, 09:42 PM Reply Like
  • Mercy Jimenez
    , contributor
    Comments (2710) | Send Message
     
    D-Inv -- it may only work with Cuban bloodlines. LOL
    mj
    13 Jun 2014, 06:30 AM Reply Like
  • doubleguns
    , contributor
    Comments (9693) | Send Message
     
    Doc, Rustoleum has a product that will water proof your boots beyond belief. Take a look. Even paint will not stick to those boots afterwards. Incredible product.

     

    http://abcn.ws/SFJ9CI
    13 Jun 2014, 08:17 AM Reply Like
  • robert.b.ferguson
    , contributor
    Comments (10491) | Send Message
     
    Greetings all: Avon used to make a product that was not for mosquito repellent but we (Troopers.) frequently used it for that purpose when deployed in tropical environments. I can't remember the name of it though. I think it was called "Skin so soft." or something like that. Do you recall that Double, Guns?
    16 Jun 2014, 05:49 PM Reply Like
  • D-inv
    , contributor
    Comments (4810) | Send Message
     
    " I think it was called "Skin so soft." or something like that. "

     

    Avon now markets "skin so soft" products as mosquito repellant. (Like Lavender extracts, does not work for my granddaughter. Neither does lemon eucalyptus oil.)
    16 Jun 2014, 07:30 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » I believe the SAS used to use it in Iraq… or so I have heard.
    16 Jun 2014, 07:32 PM Reply Like
  • optionsgirl
    , contributor
    Comments (5202) | Send Message
     
    Avon makes a Skin So Soft labelled Bug Guard Plus IR3535
    Expedition insect repellent with spf 30 sunscreen spray. It is unscented and water resistant. It comes in a green can.
    Mosquitos adore me. I highly recommend this product. (This is not the same stuff as the skin so soft body oil that some people use to discourage the pests.) I've been using buckets of this stuff since moving to FL 5+ years ago.
    I find it's tough on the skin, particularly when one is exposed to hot tub and pool chemicals, or salt water, for that matter.
    17 Jun 2014, 09:50 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    >OG-

     

    Just saw that you have reached 5000 posts!

     

    Awesome, and congrats!

     

    Re: Bug Guard Plus-

     

    SWMBO wanted me to ask

     

    "Ask if she has ever tried Herbal Armor. Available with sunscreen, gentle and effective."

     

    WT
    17 Jun 2014, 05:29 PM Reply Like
  • optionsgirl
    , contributor
    Comments (5202) | Send Message
     
    Nope, never tried herbal armor. I've got to check it out!
    17 Jun 2014, 08:11 PM Reply Like
  • robert.b.ferguson
    , contributor
    Comments (10491) | Send Message
     
    Congrats on 5K Oy, Gee!
    18 Jun 2014, 02:13 PM Reply Like
  • doubleguns
    , contributor
    Comments (9693) | Send Message
     
    Bob, sorry so late, been fishing in Iceland. We got a jeep stuck in the mud and while trying to get it out I ruptured a disk in my lower back. Major pain and trouble walking right now. Waiting MRI and most likely surgery.
    Yep skin so soft is used as a repellant but it is not effective for everyone. Its also used against gnats and other flying and biting bugs with some relief for some folks but I want something closer to 100% effective when I go out. I also have 100% deet but that's a last resort since its quite possibly trading health for comfort.
    5 Jul 2014, 09:53 AM Reply Like
  • H. T. Love
    , contributor
    Comments (19491) | Send Message
     
    Good grief Guns! You got to slow down a wee bit and take care of your body!

     

    I hope it goes well for you.

     

    HardToLove
    5 Jul 2014, 10:01 AM Reply Like
  • doubleguns
    , contributor
    Comments (9693) | Send Message
     
    What makes this so bad is I have not gotten my should surgery yet and now it will have to take a back seat to my back.

     

    Bear hunt = shoulder surgery.
    fishing trip = back surgery.

     

    Seems like common core math to me cuz its not adding up.
    5 Jul 2014, 10:06 AM Reply Like
  • D-inv
    , contributor
    Comments (4810) | Send Message
     
    "Seems like common core math to me cuz its not adding up."

     

    :-) Prompts recollection of pulling on socks a while back, noticing skin appearance around ankles I had not been aware of before, and thinking, "What happened here, that looks like an old man's skin!"

     

    Hope your surgeries are successful and scheduled to your liking.
    5 Jul 2014, 11:03 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    >DG-

     

    Better be careful-
    Seems the problems are moving down your superstructure!

     

    WT
    5 Jul 2014, 11:32 AM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » Ack Guns! Hope you get fixed up soon.
    5 Jul 2014, 02:59 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Sorry to hear this, doubleguns. Best of luck and get well soon!
    5 Jul 2014, 03:10 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » If your socks are leaving an impression around your ankles, they are too tight and decreasing circulation important to the foots skin health. I learned that from direct experience.
    5 Jul 2014, 03:19 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    FPA: Me, too. I have many rust-red looking spots on the top of both feet. Both my doc, and my dermy told me that my shoes were likely too tight. But, mostly, about 98% of the time, I only wear those ugly looking Crocs.

     

    It wasn't the Crocs, but rather, the socks.

     

    5 Jul 2014, 04:58 PM Reply Like
  • robert.b.ferguson
    , contributor
    Comments (10491) | Send Message
     
    Wow Guns! That sounds uncomfortable in the extreme! Hope all goes well from here on out.
    7 Jul 2014, 05:43 PM Reply Like
  • doubleguns
    , contributor
    Comments (9693) | Send Message
     
    Uncomfortable you say.

     

    Bob you have never been short on words before. Whats up today? LOL

     

    Thanks all for the.......um well.....comfort.
    7 Jul 2014, 06:37 PM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    Here is an interesting opportunity.

     

    http://seekingalpha.co...

     

    Orexigen was supposed to have its PDUFA date today, and almost everyone is confident the FDA would finally approve Contrave. But it got postponed three months so that (OREX) and the FDA could finalize a post-marketing study plan. The stock dropped $1.00 (14%) overnight, on what I view as good news!

     

    If the FDA was not going to approve the drug, why postpone the approval to finalize study details?

     

    I may double down today.
    11 Jun 2014, 09:57 AM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    Well, (OREX) rebounded to where it should be today to ride out the impending PDUFA. Glad I added a block at $5.79 on the dip last week. Both blocks back in the green.
    16 Jun 2014, 04:07 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Chikungunya may now be in Tennessee:

     

    http://tnne.ws/SA1vVH

     

    And also may now be in Cuba, too:

     

    http://hrld.us/SA1tNn

     

    -- But she added [a Cuban health official] that authorities had declared an “epidemiological alert” in order to start setting out the procedures to follow in case of “a possible outbreak.”
    11 Jun 2014, 04:16 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Novavax raises gross proceeds of $115M • 4:19 PM

     

    •The underwriters of Novavax's (NVAX +1.3%) equity offering have exercised their over-allotment of 3.75M shares at $4.00. This increases the net proceeds to the company to ~$108M.
    11 Jun 2014, 06:30 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » Looks like something is going on with (NVAX) this morning…
    12 Jun 2014, 10:30 AM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    WHO confirms MERS in Iran as Kuwait finds virus in camels

     

    http://bit.ly/1iqMtsr

     

    So any ideas what is moving NVAX today?
    12 Jun 2014, 10:41 AM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » I believe there is a shareholders meeting today…
    12 Jun 2014, 10:46 AM Reply Like
  • optionsgirl
    , contributor
    Comments (5202) | Send Message
     
    Mayascribe: ZLCS is up 28+/-% !!
    12 Jun 2014, 11:59 AM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    OG: Back from the dead! I don't understand the merger, though, as the merger has been known about for a while.
    12 Jun 2014, 12:06 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » (ZLCS) popped Thursday after Epirus Switzerland announced clinical data from a Phase 3 study of BOW015. The study was an equivalence trial comparing BOW015 to Remicade. BOW015 reached an ACR20 response rate of 89.8%, compared to 86.4% for Remicade, in week 16. Woo Woo for the smart holders… Rats for the rest of us.
    12 Jun 2014, 12:09 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Seems like every bio I own- or for that matter follow is up today- Sector rotation?

     

    WT
    12 Jun 2014, 12:13 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » I noticed that too WT…
    12 Jun 2014, 12:24 PM Reply Like
  • optionsgirl
    , contributor
    Comments (5202) | Send Message
     
    Trust SmartyRat to find out why it popped!
    It's not too late to enter ZLCS. It's in the $1.30's. Last year it was over $8.00.
    12 Jun 2014, 12:13 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » So smart, I am late to the party… :)
    I took your advice, and bought a starting position… I suspect it will retrace a bit, than I will pick up some more. Thanks OG and MAYA!
    12 Jun 2014, 12:23 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    WTG, FPA!

     

    Zalicus now up 38%!
    12 Jun 2014, 03:17 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » Jsss… I got in late to the party, and I am still up big!
    Thanks guys!!!!
    12 Jun 2014, 03:53 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Re:(BDSI)

     

    Let's give credit to LT for calling attention to this popper on Tuesday-
    $9.50 then $12.59 today.

     

    WT
    12 Jun 2014, 12:36 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » Nice Job LT!

     

    I don't thank LT and all the other members of this concentrator enough for all of the time and effort and obvious caring you guys put into this. Without you guys, this would just be another forgettable pile of soulless empty musings.
    12 Jun 2014, 12:45 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Hey, Rattie-

     

    If it weren't for your efforts the site wouldn't be here!

     

    WT
    12 Jun 2014, 12:51 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    April 16 -- Epirus Biopharmaceuticals to merge with Zalicus

     

    http://bit.ly/1irbyTX
    12 Jun 2014, 01:16 PM Reply Like
  • optionsgirl
    , contributor
    Comments (5202) | Send Message
     
    Epirus made the announcement about ZLCS. That leads me to believe they've already merged.
    12 Jun 2014, 02:10 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    My take, too, OG. But I still don't grasp the ramifications of the deal -- not much out there I could find.
    12 Jun 2014, 02:15 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Epirus Biopharma buys Zalicus

     

    Jun 12 2014, 16:16 ET | About: Zalicus Inc. (ZLCS)

     

    Privately-held biosimilar developer Epirus Biopharmaceuticals acquires Zalicus (ZLCS +38.9%) in an all-stock deal. The post-merger firm will be named Epirus Biopharmaceuticals. Current ZLCS shareholders will own ~19% of the combined enterprise. Their proportion could go down as low as 14% if Zalicus' cash position falls below $9M at closing.

     

    Epirus's pipeline includes biosimilars for Janssen's (JNJ -0.8%) Remicade, AbbVie's (ABBV -1.1%) Humira and Genentech's (RHHBY -0.6%) Avastin.

     

    ####

     

    Well, OG, I guess we didn't get that one right!
    12 Jun 2014, 04:49 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    First confirmed NC case of mosquito-borne chikungunya virus reported in Forsyth Co.

     

    http://bit.ly/1xP7hUf

     

    US Virgin Islands Confirms 1st Chikungunya Case

     

    http://abcn.ws/1xP7fvB
    12 Jun 2014, 01:20 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Though I didn't know (that I did know) about chikungunya in the way back machine, the below PDF from 2009 mentions that Cadila Pharm and Novavax were working on a vaccine for chikungunya back in 2009:

     

    -- The VLP is believed to be well suited to the development of vaccines against diseases endemic
    to India and surrounding regions like dengue fever and chikungunya fever. Dengue fever is a
    mosquito-borne disease, which has re-emerged in India and has a very high mortality rate.
    Currently, there is no vaccine or definitive treatment for Dengue fever.

     

    http://bit.ly/1irfoMP[1].pdf

     

    Not sure whatever happened to the joint Cadila/Novavax venture in India.

     

    ####

     

    August 2011 -- Researchers Create New Experimental Vaccine Against Chikungunya Virus

     

    http://bit.ly/1irfpR0
    12 Jun 2014, 01:39 PM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    All of the cases of Chikungunya reported in USA so far have been travel related (except the one case in Puerto Rico).

     

    http://1.usa.gov/1xPgaNu

     

    That NC case is reported to be Caribbean travel related in other stories.
    12 Jun 2014, 01:52 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » I can add some color on Cadila Maya:

     

    NVAX has an on-going joint venture with Cadila Pharmaceuticals Limited called CPL Biological Private Limited or CPLB.

     

    CPLB is developing and manufacturing vaccines, biological therapeutics and diagnostics in India. CPLB is owned 20% by NVAX and 80% by Cadila.

     

    CPLB operates a state-of-the-art manufacturing facility in India for the production of vaccines and is actively developing a number of vaccine candidates that were genetically engineered by NVAX.

     

    Here is a list of current CPLB trials in India:

     

    Seasonal Trivalent Influenza - Phase 1/2
    Pandemic (H1N1) Influenza - Phase 1/2
    Rabies - Phase 1/2
    12 Jun 2014, 01:54 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Doc: Yes, every US case is travel related...so far. The problem is that the incubation period is anywhere from 1 to 12 days.

     

    From Wikipedia:

     

    The incubation period of chikungunya disease ranges from one to twelve days, typically two to three. The majority of those infected will develop symptoms.[6] Symptoms include a fever up to 40 °C (104 °F), a petechial or maculopapular rash of the trunk and occasionally the limbs, and arthralgia or arthritis affecting multiple joints.[7] Other nonspecific symptoms can include headache, nausea, vomiting, conjunctivitis, slight photophobia and partial loss of taste.[8] Ocular inflammation from chikungunya may present as iridocyclitis. Retinal lesions may also occur.[9] Pedal oedema (swelling of legs) is observed in many patients, the cause of which remains obscure as it is not related to any cardiovascular, renal or hepatic abnormalities.

     

    Typically, the fever lasts for two days and then ends abruptly. However, other symptoms—namely joint pain, intense headache, insomnia and an extreme degree of prostration—last for a variable period; usually for about five to seven days.[7] Patients have complained of joint pains for much longer time periods; some as long as two years, depending on their age.[10][11] Recovery from the disease varies by age. Younger patients recover within 5 to 15 days; middle-aged patients recover in 1 to 2.5 months. Recovery is longer for the elderly. The severity of the disease as well as its duration is less in younger patients and pregnant women. In pregnant women, no untoward effects are noticed after the infection.
    12 Jun 2014, 01:57 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Thanks, FPA!
    12 Jun 2014, 02:16 PM Reply Like
  • doubleguns
    , contributor
    Comments (9693) | Send Message
     
    The global incident map has lots of hits for dengue and Chikungunya that you can review doc.

     

    http://bit.ly/tb0kz2

     

    Florida is just covered in Chikungunya cases.
    12 Jun 2014, 05:50 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    DG: I've been tracking that site daily for the past couple of weeks, and watching those menacing little red boxes that keep popping up all over the place.
    12 Jun 2014, 05:57 PM Reply Like
  • doubleguns
    , contributor
    Comments (9693) | Send Message
     
    Be careful because it can become addicting. After the Japan quakes I was checking it several times a day to see what tremors were doing. I found myself consumed by wondering what was happening when I was not watching that I could not stop watching. Had it minimized 24/7 so I could peek real fast. LOL....now that I am not plagued by the addiction.
    13 Jun 2014, 08:25 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    The latest Chikungunya in the USA was in Tennessee....too close to my home in KY to suit me.

     

    It's on Yahoo.
    12 Jun 2014, 09:06 PM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Nektar +9% AH on FDA panel recommendation
    Nektar Therapeutics (NKTR) +9.2% AH after a long trading halt, as an FDA advisory panel recommended against requiring cardiovascular outcome trials for a certain class of drugs - including NKTR's Movantik - in the treatment of constipation caused by opioid medicines (earlier).The drug treatment, being developed by NKTR partner AstraZeneca (AZN), also is being reviewed by health agencies in the European Union and Canada.The FDA is expected to make a decision on Movantik by Sept. 16.

     

    | 6:48 PM|Comment!
    13 Jun 2014, 04:20 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Progenics schedules conference call to discuss Ad Comm recommendation
    Progenics Pharmaceuticals (PGNX +9.2%) CEO Mark Baker will comment tomorrow in a conference call on the FDA's Anesthetic and Analgesic Drug Products Ad Comm vote recommending against large clinical trials to assess the cardiovascular risk of the class of drugs that treat opioid-induced constipation. The call will start at 8:30 am EDT.

     

    | 6:06 PM|Comment!
    13 Jun 2014, 04:21 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    FDA finally made a good move

     

    Ad Comm recommendation bodes well for opioid-induced constipation drugs
    The FDA's Anesthetic and Analgesic Drug Products Advisory Committee recommends the FDA not require large clinical trials to assess the cardiovascular risk of the class of drugs to treat opioid-induced constipation.Initially, seven members voted for the need for the trials, five voted in favor of trials for select products and twelve voted against the need for the trials. In a post-vote discussion, several members stated that they misunderstood the question and would have voted against the need for the trials.The recommendation, if adopted by the FDA, would potentially mitigate a time-consuming and expensive hurdle for the drug makers in their NDA application efforts.Related tickers: (CBST -0.6%) (NKTR) (SLXP +3.2%) (THRX -2.4%) (PGNX)

     

    |12:54 PM|2 Comments
    13 Jun 2014, 04:38 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    i like this one

     

    Bullish chart action for TG Therapeutics
    Shares of nano cap TG Therapeutics (TGTX +20.8%) break out today on a seven-fold increase in volume as it continues its post-ASCO up move. At the American Society of Clinical Oncology meeting several weeks ago, the company presented data on its two lead products. The data are encouraging albeit in Phase 1 trials on a small number of subjects.In a 35-patient Phase 1 single agent study of TG-1101 (ublituximab) in lymphoma, 100% of chronic lymphocytic leukemia (CLL) patients achieved a peripheral response (6/6) and 67% (4/6) achieved a partial response. 22% (4/18) of Indolent non-Hodgkin Lymphoma patients (iNHL) achieved a complete or partial response.In a Phase 1 trial of its PI3K delta inhibitor TGR-1202, 100% (9/9) of evaluable CLL patients dosed at e 800 mg showed significant nodal reductions and 78% (7/9) achieved a partial response or a nodal partial response with lymphocytosis.TGTX debuted on the NASDAQ on May 30, 2013 closing at $6.25 on Day 1.73 mutual funds have positions in the stock, up from 51 a year earlier.

     

    | 5:23 PM|Comment!
    13 Jun 2014, 04:23 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Merck research chief says the firm is open to more deals
    At an investors meeting in Los Angeles, Merck (MRK -0.9%) EVP and President, Merck Research Laboratories Roger Perlmutter, M.D., Ph.D., says the company will consider large acquisitions as way to expand its product portfolio rather than obtain drug-development technologies. He says Merck continues to have an appetite for deals following its recent buy of Idenix (IDIX +0.3%) for $3.85B.

     

    | 3:57 PM|1 Comment
    13 Jun 2014, 04:26 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    I like the good news out today on Arthritis drugs, they seemed to work....lots of potential too.

     

    Positive Phase 3 results for sarilumab
    In a 1,197-subject Phase 3 clinical trial evaluating the safety and efficacy of sarilumab in patients with moderate-to-severe rheumatoid arthritis (RA) who have not responded adequately to methotrexate (MTX) therapy, the mAb met all three co-primary endpoints: demonstrating improvement in disease signs and symptoms at 24 weeks, physical function at 16 weeks and inhibition of joint damage progession at 52 weeks. All results were statistically significant.On a secondary endpoint, sarilumab combined with MTX showed a statistically significantly greater effect than MTX alone in achieving a major clinical response for at least 24 weeks.Sarilumab is a human mAb that is an IL-6 inhibitor. By blocking the binding of IL-6 to its receptor, it interrupts the resultant cytokine-mediated inflammatory signalling.Sarilumab is being co-developed by Regeneron Pharmaceuticals (REGN -0.2%) and Sanofi (SNY).
    13 Jun 2014, 04:46 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Provectus to hold CC to discuss PV-10 development plan
    At 4 pm EDT on June 19, Provectus Biopharmaceuticals (PVCT +9.8%) will hold a conference call to present its plans for the continued development of its cancer drug candidate PV-10. Management will discuss its proposed Phase 3 clinical trial for melanoma and its progress in developing PV-10 for other cancer indications.Management will also present its plans to monetize PV-10 and PH-10 via licensing and co-development agreements.

     

    |10:26 AM|4 Comme
    13 Jun 2014, 04:54 AM Reply Like
  • doubleguns
    , contributor
    Comments (9693) | Send Message
     
    Kawaoka back at it again. Scientists create deadly Spanish flu-like virus in lab. Excerpts below.

     

    Previously, Kawaoka has been criticized for his creation of an altered H5N1 bird flu virus that along with similar H5N1 work by Dutch researcher Ron Fouchier sparked a year-long moratorium on the experiments two years ago.

     

    U.S. researchers said Wednesday they have used fragments of circulating avian flu viruses to successfully create a deadly flu virus that was very similar to the one that caused the 1918 pandemic, the most devastating disease outbreak ever recorded.

     

    Such experiments pose "a significant risk to public health, arguably the highest level of risk posed by any biomedical research," they wrote.

     

    "The dangers are not just hypothetical. The H1N1 influenza strain responsible for significant morbidity and mortality around the world from 1977 to 2009 is thought to have originated from a laboratory accident," they added.

     

    Full link: http://bit.ly/1lsImjE
    13 Jun 2014, 08:35 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Shades of "The Andromeda Strain."
    13 Jun 2014, 06:43 PM Reply Like
  • Mercy Jimenez
    , contributor
    Comments (2710) | Send Message
     
    Some perspective on the Hep C space from Bret Jensen. Conatus Pharmaceuticals (CNAT) is discussed: http://seekingalpha.co...
    mj
    13 Jun 2014, 10:31 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    >MJ-

     

    Re: (CNAT) Thanks for the heads-up!

     

    Took a position this morning @ $7.70

     

    WT
    16 Jun 2014, 09:59 AM Reply Like
  • Mercy Jimenez
    , contributor
    Comments (2710) | Send Message
     
    Very nice WT -- this is a jumpy one indeed.
    mj
    16 Jun 2014, 01:28 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Out of (CNAT) for a quick 6%- Very little volume support and Zero Block trades!

     

    WT
    16 Jun 2014, 01:42 PM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    heres one to watch and see who gets it...its a winner

     

    Progress made on a 'bionic pancreas' for diabetics
    http://yhoo.it/UFjhZI
    16 Jun 2014, 06:45 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Novartis manufacturing facility on go for vaccine prodution
    The FDA licenses Novartis' (NVS +1.1%) North Carolina manufacturing facility for the production of cell culture influenza vaccines on a seasonal and pre-pandemic basis. It is the first such site approved in the U.S. It has the scale to ramp up production in the event of a pandemic.The company will employ its cell culture technology to product its Flucelvax influenza vaccine which was the first FDA-approved vaccine not made with chicken eggs.
    16 Jun 2014, 11:58 AM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Cases of chikungunya continue to explode:

     

    -- “My conservative estimate for Haiti is at least a million cases so far, and probably more. We will obviously never know the true numbers. I have been working in Haiti for 16 years (I'm an ER doctor) and I've never seen anything like this."

     

    -- In a story dated June 15, Prensa Libre quotes the Salvadoran Health Minister Violeta Menjivar, as stating that her nation has reports of at least 1,200 cases of chikungunya. If confirmed by laboratory testing, these would be the first locally acquired infections from this mosquito borne virus in Central America. Panama has reported imported cases. Costa Rica has reported suspected cases but none have been confirmed by testing.

     

    -- The more accurate, though not real time, report from the Pan American Health Organization (PAHO) was released June 13. In Number of reported cases of Chikungunya Fever in the Americas, the agency lists 4,576 confirmed cases and 165,990 suspected cases for a total of 170,566. The primary difference is that the PAHO report includes an update from the Dominican Republic showing an additional 24,000 plus suspected cases over the last week.

     

    http://exm.nr/SNJFPd
    16 Jun 2014, 12:13 PM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    short?

     

    Ligand Pharmaceuticals - Severe Competitive Threat To Key Royalty Program And 'Going Concern' Risk Drive 100 Percent Downside
    http://seekingalpha.co...
    16 Jun 2014, 05:18 PM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Bearish outlook for Ligand from Lemelson Capital
    Shares of Ligand Pharmaceuticals (LGND -2.8%) had an up-and-down session today. Shares were up 4.6% to $69.84 late morning but reversed in the afternoon after SA published a bearish article by Lemelson Capital that predicts a price of $0/share.

     

    Shares bottomed at $63.27 (-5.2%) before recovering a bit to close at $64.89 (-2.8%). Volume was 2x higher than average but the issue is thinly traded.

     

    Total turnover was only 583K shares.Lemelson says the company is due for a significant down move because of the threat to Promacta, its principal source of royalties, from Gilead's Sovaldi (and eventually others).

     

    The logic is that if HCV infection can be cured then there will be much less demand for a drug that treats low platelet counts in people with HCV (Promacta is also indicated for patients with low platelet counts with chronic ideopathic thrombocytopenia).

     

    Lemelson also says LGND's P/E ratio of 115 is excessive when compared to members of Big Pharma. This may be, but the comparison should really be made against the biotech industry as a whole. Per MSN Money, the industry's P/E is 108 so Ligand's value is not excessive on this criterion.

     

    Other metrics that would be more informative than P/E would be P/S (LGND: 26.3 vs 9) and P/B (21.3 vs 8.1).

     

    Consensus estimates for earnings and revenues for Q2 and Q3 are $0.14/share on revenues of $9.8M and $0.42/share on revenues of $16.7M, respectively.

     

    Consensus views for 2014 and 2015 are earnings of $1.44/share on revenues of $62.9M and $2.54/share on revenues of $88M,

     

    respectively.288 mutual funds have positions, up from 175 a year earlier.
    | 4:44 PM|Comment!
    16 Jun 2014, 05:21 PM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Positive Phase 3 results for empagliflozin
    Eli Lilly (LLY -0.3%) and development partner Boehringer Ingelheim announce positive top-line results from two Phase 3 trials of empagliflozin as a treatment for type 2 diabetes.

     

    In a two-year 1,545-patient study comparing the safety and efficacy of empagliflozin with glimepiride each in combination with metformin, at 104 weeks patients in the empagliflozin cohort had significantly greater reductions in A1C, body weight and systolic and diastolic blood pressure from baseline compared to the glimepiride cohort.

     

    There were also significantly fewer hypoglycemic events in the empagliflozin group.In a 52-week placebo-controlled study of obese inadequately controlled type 2 diabetes patients on multiple daily insulin injections with or without metformin, empagliflozin significantly reduced A1C levels from baseline compared to the control group.

     

    Patients in the test group lost an average of 2 kg of weight versus a 0.4 kg average gain in the placebo group.
    16 Jun 2014, 05:23 PM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Regulatory clearance for Alere flu test
    Via its 510k process, the FDA approves Alere's (ALR +1.9%) i Influenza A&B diagnostic test, the only molecular test that can detect and differentiate the influenza A and B virus in less than 15 minutes.

     

    The product was launched in Europe earlier this year.The firm has rapid molecular tests in development for Strep A, C. difficile, RSV and chlamyida/gonorrhea.
    16 Jun 2014, 05:32 PM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Inovio Pharmaceuticals Broadens its Intellectual Property Portfolio from the University of Pennsylvania
    http://bit.ly/1pEB5ke
    17 Jun 2014, 08:24 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Noble Financial is moving its price target on BioCryst (Nasdaq: BCRX) from $16 up to $19 following results from BCX4161 Phase 2a in HAE.

     

    The firm has BioCryst with a Buy rating.
    Analyst Rahul Jasuja, PhD, noted the following key points for the study:The Phase 2a trial (OPuS-1) marked the first oral plasma kallikrien inhibitor study in HAE patients;

     

    preliminary results met expectations for BCX4161 as a prophylactic on efficacy and safety in a patient population with high attack rates;

     

    BCX4161 treatment resulted in a statistically significant mean attack rate reduction of 0.45 attacks per week versus placebo, p
    Copyright 2014, Street Insider News Provided by Acquire Media Corporation
    18 Jun 2014, 09:25 AM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    (CUR)

     

    Neuralstem Final Phase I Depression Data Presented At The American Society Of Clinical Psychopharmacology Annual Meeting

     

    http://bit.ly/1pfN9Vu

     

    Looks very positive.
    18 Jun 2014, 10:09 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Re: (CUR) results-

     

    Check out (STEM) - Up 30% last three days.

     

    Comments?

     

    WT
    19 Jun 2014, 11:46 AM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » Zalicus (ZLCS) licenses its Sodium Channel Modulator program including IP and related pipeline assets to AnaBios Corporation. Under the terms of the agreement, Zalicus will be eligible to receive as much as $17.2M in clinical and regulatory milestone payments and up to 12% in royalties on future net sales of any product resulting from the license.
    18 Jun 2014, 11:30 AM Reply Like
  • robert.b.ferguson
    , contributor
    Comments (10491) | Send Message
     
    On the 16th day of June in the year of our Lord 2014 Mystic the flying rat dog flew off to meet her maker. She left peacefully in her bed. Mystic Born 1, January 2000- Died 16, June 2014. We learned much from her. She fought the good fight until she could fight no more. She will be greatly missed!
    18 Jun 2014, 02:18 PM Reply Like
  • H. T. Love
    , contributor
    Comments (19491) | Send Message
     
    A hole in the family that will not be easily filled Robert. Lost ours a couple years back and still find myself occasionally looking for him.

     

    HardToLove
    18 Jun 2014, 02:21 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Condolences, Robert.
    18 Jun 2014, 02:26 PM Reply Like
  • robert.b.ferguson
    , contributor
    Comments (10491) | Send Message
     
    Thanks to all for sharing and caring.
    18 Jun 2014, 05:31 PM Reply Like
  • D-inv
    , contributor
    Comments (4810) | Send Message
     
    Ditto to all expressed by HTL. When working in the yard (particularly), sporadically experience my "mind's eye" seeing departed 'members of the family' in characteristic activities/locations.

     

    Our black Labrador Retriever was part of the family for a bit over 14 years as well Robert.
    18 Jun 2014, 10:15 PM Reply Like
  • doubleguns
    , contributor
    Comments (9693) | Send Message
     
    Sorry to hear that Rob. I have been down that road many times. We have three dogs now and one is 13 years old now and ageing fast. Its a real heartbreak when they go but what we get in those years we have them is irreplaceable.
    5 Jul 2014, 09:58 AM Reply Like
  • robert.b.ferguson
    , contributor
    Comments (10491) | Send Message
     
    Thanks Guns. You are right on both counts.
    7 Jul 2014, 05:46 PM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    So sorry Robt. We have our 3rd Shi-Zhu and they are like family. I have shared the same loss as you and it's a tough thing for us.
    18 Jun 2014, 08:55 PM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    (NWBO) opportunity knocking. AF hit piece slammed the price this AM.

     

    http://bit.ly/1uFUPSo
    19 Jun 2014, 10:17 AM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    Doubled down today on NWBO, at $7.45.
    19 Jun 2014, 12:23 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » Pomerantz Law Firm Investigates Claims On Behalf of Investors of Northwest Biotherapeutics, Inc. - NWBO.

     

    Part of the slam?
    19 Jun 2014, 12:47 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Thanks for the 'heads up' Doc-

     

    Back in at $7.26.

     

    WT
    19 Jun 2014, 01:13 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » The Rosen Law Firm Announces Investigation of Securities Fraud Claims Against Northwest Biotherapeutics, Inc. – NWBO ??
    19 Jun 2014, 01:20 PM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    SA repeats AF's claims. Comments of interest.

     

    http://seekingalpha.co...
    19 Jun 2014, 01:31 PM Reply Like
  • Al Marshall
    , contributor
    Comments (631) | Send Message
     
    I loaded up on NWBO at around $6 after AF's last round of bashing and increased my position about 15% this morning. My regret is that I only reduced my position by 4% after the recent 50% runup.

     

    I'm very high on NWBO (the German Hospital Exemption seems like a game changer to me) while the market is extremely skittish as it seems to listen to AF. It would appear that there might be a huge trading opportunity here as NWBO and AF play ping-pong on a weekly basis.
    19 Jun 2014, 04:10 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Re:(NWBO)

     

    >Al- Thanks-

     

    I agree on the trading opp for sure!

     

    I have been in and out several times taking profits all the way except for an ill-advised CALL I bot.
    The simultaneous trials with Germany and the US is what swayed me originally. I sold all holdings several weeks ago with the run-up and figured I missed my opportunity.

     

    AF does a lot of undeserved damage quite often. I admit that I have seen situations when he is not negative at all- Few as they may be.

     

    Unfortunately too many hang on every word even though a lot of what he spouts is pure speculation, not even rumor, except of course in his own narcissistic head.

     

    WT
    19 Jun 2014, 08:44 PM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    NW BIO REAFFIRMS DCVAX(R)-DIRECT CLINICAL TRIAL INTERIM DATA ANNOUNCEMENTS

     

    Company Refutes Latest Feuerstein False Headline and Attacks

     

    http://bit.ly/1noesKT

     

    >>
    Linda Powers, CEO of NW Bio, commented: "As NW Bio continues to make strong progress in multiple programs with two product lines, for both operable and inoperable tumors, and as NW Bio's clinical programs show encouraging early effects, Feuerstein seeks ever more sensationalized ways to try to smear the Company. This is not even the semblance of professional analysis. We condemn this attack campaign and appreciate the strong support we are receiving from shareholders, patients and other commentators. We intend to continue our progress undeterred."
    <<
    20 Jun 2014, 11:09 AM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    Another good (NWBO) discussion here:

     

    The War Of Words: Balancing Perspectives On Northwest Bio's DCVax-Direct

     

    http://seekingalpha.co...
    20 Jun 2014, 04:41 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    >SM-

     

    Thanks, Doc-
    Very thorough clarification.

     

    WT
    20 Jun 2014, 06:01 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Re:(NWBO)

     

    Check this Short Interest- 6,570,000 shares equals 11.6% of the float!

     

    WT

     

    Edit- 10 days to cover.
    19 Jun 2014, 02:33 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Re:(NVAX)

     

    Bought in my 30 PUT contracts of NVAX $5s of July 17 at $.50 for a gain of 55%. (Nvax at $4.82 at the time).

     

    Although I believe NVAX is going higher, buying in the PUTSs frees up a lot of cash right now.

     

    WT
    19 Jun 2014, 04:01 PM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Encouraging results for StemCells' platform in AMD
    Shares of StemCells (STEM +22.9%) jump on heavy volume in response to its announcement of positive interim results from the Phase 1/2 clinical trial of its HuCNS-SC human neural stem cell platform in dry age-related macular degeneration (AMD), albeit on a small group of seven patients.The platform showed a 65% reduction in the rate of geographic atrophy (GA) in the study eye compared to the expected natural history of the disease and a 70% reduction in the rate of GA compared to the control eye. GA is the progressive loss of two retinal tissue layers (photoreceptors and retinal pigmented epithelium) that cause vision loss in dry AMD.The company expects to initiate a Phase 2 proof-of-concept study later this year.
    20 Jun 2014, 04:50 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Vital Therapies (VTL) on a roar- 8% today so far.

     

    I don't find anything but I'm sure there is news that someone is aware of.

     

    WT
    20 Jun 2014, 11:17 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Meditronic (MDT) buys Covidien for $43 Billion-

     

    Here's why-

     

    http://econ.st/1noiVgt

     

    (also on QC)

     

    WT
    20 Jun 2014, 11:37 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    FWIW-

     

    (NVAX) $5.00+ just before close-

     

    WT

     

    Edit: I am still Long
    20 Jun 2014, 03:51 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    WT: Weeeehooooo! Shares I bought on the 6th of June are up almost 20% ;-0.
    20 Jun 2014, 04:02 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    >Maya-

     

    Re: (NVAX) 20%- Great!

     

    Mine is a little less, about 17%.

     

    Let's hope it heads North some more!

     

    Now, if we could only get Stellar to move.......

     

    WT
    21 Jun 2014, 02:25 PM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    INOVIO

     

    Co announces it has initiated a phase I/IIa clinical trial to evaluate safety, immunogenicity, clinical responses and disease-free survival of its DNA immunotherapy product, INO-3112, in treating human papillomavirus-associated cervical cancer.

     

    INO-3112 is a combination of Inovio's lead active immunotherapy product, VGX-3100, and its proprietary immune activator expressing interleukin-12.

     

    VGX-3100 is currently being evaluated in a randomized phase II efficacy trial for the treatment of high grade cervical dysplasia.This open-label study, called HPV-004, will evaluate INO-3112 in 20 female subjects with inoperable invasive cervical cancer.

     

    Subjects will receive four treatments of INO-3112 every four weeks after completion of a standard chemoradiation regimen. Each INO-3112 treatment will be a combination of 6 mg of VGX-3100 and 1 mg of DNA-based IL-12 delivered together intramuscularly with the CELLECTRA delivery system.Copyright (C) 2010 Briefing.com
    23 Jun 2014, 09:10 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Re: (INO)

     

    Some very slightly disguised contempt for the stock destroyer we love to hate.

     

    http://bit.ly/1wnKYn4

     

    WT
    23 Jun 2014, 12:51 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » AF's 'Hit" articles are often a buy signal for me. I think there is a commonality among AF's "Hit" articles. I have been thinking of doing on article on that… I think he and the people he represents are smart, but if you do something often enough, a structure usually emerges, particularly if you do it repeatedly in the same sector.
    23 Jun 2014, 02:58 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    >FPA-

     

    One comment the author made was that within seconds (literally) of AF's article being published the stock had dropped significantly on large volume.

     

    Gee- Ya think anyone could possibly read it that fast and put a sell order in?

     

    Wow!

     

    And I thought my Ellen Woods speed-reading course was good.

     

    WT
    23 Jun 2014, 04:14 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » Exactly WT… That was one of the things I was going to look at.
    23 Jun 2014, 04:22 PM Reply Like
  • jpau
    , contributor
    Comments (967) | Send Message
     
    John Oliver's take on Dr. Oz

     

    http://bit.ly/1yHbee7
    23 Jun 2014, 08:53 PM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Successful Phase 3 results for CF drug combo
    Shares of Vertex Pharmaceuticals (VRTX) are up a whopping 50% premarket on heavy volume in response to its announcement of successful results in two Phase 3 clinical trials for the combination of lumacaftor/ivacaftor as a treatment for patients aged 12 and older with cystic fibrosis (CF) who have two copies (homozygous) of the F508del mutation in the CF transmembrane conductance regulator (CFTR) gene, the most common form of the disease.

     

    All four treatment arms met their primary endpoints of mean absolute improvement in ppFEV1 from baseline versus placebo at the end of treatment.

     

    Pooled analysis of the studies showed statistically significant reductions of 30% and 39% in the rate of pulmonary exacerbations in patients receiving the combination therapy compared to placebo.

     

    Based on these data, Vertex plans to submit an NDA to the FDA and a MAA to Europe's EMA in Q4 2014 for CF patients at least 12 years old who have two copies of the F508del mutation.
    24 Jun 2014, 09:40 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    VRTX up $27 +
    24 Jun 2014, 09:53 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Keryx Biopharma (NASDAQ: KERX) is seeing notable upside off the open. Shares are up 4.9%. A speculative article from SeekingAlpha about a potential take-out could be contributing to the gains.
    Copyright 2014, Street Insider News Provided by Acquire Media Corporation
    24 Jun 2014, 09:53 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Thrombogenics down big

     

    Shares of ultra thinly-traded Thrombogenics NV (OTCPK:TBGNF) (OTC:TBGNY) are down 41% on turnover of 4,000 shares in response to its announcement that it has decided to continue as a stand-alone company instead seeking to be acquired.

     

    It will also pursue discussions about a potential partnership for the commercialization of Jetrea (ocriplasmin) in the U.S.Separately,

     

    CFO Chris Buyse resigns effective June 30, 2014, Board member Luc Phillips will take on the role until a permanent replacement is hired.

     

    |12:37 PM|Comment!
    24 Jun 2014, 01:37 PM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    PRINCETON, N.J., June 25, 2014 (GLOBE NEWSWIRE) -- Advaxis, Inc.
    http://bit.ly/1iFnuXF
    (Nasdaq:ADXS), a clinical-stage biotechnology company developing cancer immunotherapies,

     

    today announced that the Company will be added to the Russell Microcap Index when Russell Investments
    reconstitutes its comprehensive set of U.S. and global equity indices on June 27.

     

    A preliminary
    list of companies in the Microcap and other indices is at http://bit.ly/1iFnuXH
    25 Jun 2014, 09:02 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    A very risky but possible trade:

     

    Geron Set To Explode As FDA Releases Partial Clinical Hold On Imetelstat Myelofibrosis Trial

     

    http://seekingalpha.co...
    30 Jun 2014, 11:11 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    >LT-

     

    Re: (GERN) Thanks-

     

    Good article- I took a few hundred shares.

     

    WT
    30 Jun 2014, 01:59 PM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Inovio Pharmaceuticals Added To Russell Global, Russell 2000® and Russell Microcap® Indexes
    1 Jul 2014, 06:16 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Harvard Bioscience: Forgotten Stock Poised To Deliver Near-Term Results

     

    http://seekingalpha.co...
    1 Jul 2014, 06:37 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Galena receives notice of allowance of NeuVax patent
    The USPTO issues a notice of allowance to Galena BioPharma (GALE) of a patent covering the use of NeuVax alone or in combination to prevent recurrence of any HER2/neu-expressing tumor having a fluorescence in situ hybridization (FISH) rating of less than ~2.0. The patent, once issued, will expire in 2028.

     

    NeuVax is a peptide immunotherapy for the prevention of cancer recurrence. It is Galena's lead product. Currently, there are no approved HER2-directed therapies for patients with FISH ratings <

     

    2.0.GALE shares are up 11% premarket on higher volume.
    1 Jul 2014, 09:44 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    * West Africa Ebola outbreak largest ever, with 467 dead * Farrar says "out of control" disease needs new approach * Drugs still in development could be offered to patients * Normal drug testing and approval process takes years By Kate Kelland, Health and Science Correspondent LONDON, July 2 (Reuters) - People at high risk of dying in West Africa's Ebola outbreak should be offered experimental medicines to see if they work, despite the drugs being not fully tested, the head of an influential global health charity said. Jeremy Farrar, a professor of tropical medicine and director of The Wellcome Trust charity, said Ebola's spread in Guinea, Sierra Leone and Liberia is "out of control" and global health authorities should rethink the approach to potential treatments. "We have more than 450 deaths so far - and not a single individual has been offered anything beyond tepid sponging and 'we'll bury you nicely'," Farrar told Reuters in an interview. "It's just unacceptable."
    2 Jul 2014, 07:36 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    Zogenix Provides Update on Development of Abuse Deterrent Formulations of Zohydro(R) ER
    http://bit.ly/1sWOKWb
    2 Jul 2014, 07:38 AM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    (CEMP)

     

    Preterm birth breakthrough as antibiotic penetrates placenta

     

    http://bit.ly/1sXdm0M

     

    Not sure why this paper published last fall is just now getting headline news, but solithromycin may turn out to be the first effective antibiotic to treat intrauterine infections which cause premature births.

     

    The sheep model study is available here: http://bit.ly/1rXCSPt

     

    Replication in humans would take some time to get a specific FDA indication, but could significantly extend the patent protection and value of this drug when it does finally get to market.
    2 Jul 2014, 10:51 AM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    (CEMP) getting hammered today, too, along with other good biotechs. Wm%R -96.

     

    Another buying opportunity.
    8 Jul 2014, 12:27 PM Reply Like
  • SMaturin
    , contributor
    Comments (2268) | Send Message
     
    I had my (NASDAQ:CEMP) called away last week on 7.50 calls, making me a 20% gain overall. It had a very nice run this past six weeks, topping out around 11.50.

     

    Now back down into oversold W%R territory, so I am looking to get back in when it hits bottom BB.

     

    Solithromycin remains a great bet for a blockbuster broad-spectrum antibiotic when it finally gets the green light from FDA.

     

    My strategy notes:

     

    Solithromycin is new macrolide with potentially better resistance-proof activity.
    Has anti-inflammatory activity independent of antimicrobial action.
    Has placental penetration no other abx can match, so potentially great application for intrauterine infection treatment to prevent premature births.
    Strong insider ownership.
    6/23/14: "Cempra Holdings presently has an average rating of Buy and an average target price of $15.63."
    P3 trials: Community-acquired pneumonia: "Data from this study are expected in 1H14."
    21 Aug 2014, 11:47 AM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Table. Chikungunya virus disease cases reported to ArboNET — United States, 2014 (as of July 1)*

     

    Table. Chikungunya virus disease cases reported to ArboNET — United States, 2014 (as of July 1)*

     

    ####

     

    Anyone know why NVAX is back over $5.00?
    2 Jul 2014, 12:37 PM Reply Like
  • H. T. Love
    , contributor
    Comments (19491) | Send Message
     
    Maya: The NVAX behavior seen for so long? Climb up as we move towards options expiration week, 7/19?

     

    HardToLove
    2 Jul 2014, 12:53 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Oops. Here's the chart. I was surprised how many states now have chikungunya -- still no US born cases...yet:

     

    http://1.usa.gov/1sXDglc
    2 Jul 2014, 01:00 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    HTL: Could be. I nearly bought back in on Friday based on the technicals, but decided against it.
    2 Jul 2014, 01:02 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Re: (NVAX)

     

    I have several NVAX blocks yet and considered writing some CALLs but premium is non-existent for July and August CALL expiry.

     

    WT
    2 Jul 2014, 02:28 PM Reply Like
  • H. T. Love
    , contributor
    Comments (19491) | Send Message
     
    After seeing (NWBO) technicals turn the way I wanted, started small position at $7.07. Two more positions to do.

     

    Thanks for the heads up Doc and all!

     

    HardToLove
    2 Jul 2014, 01:56 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    >HTL-

     

    Re: (NWBO) Technicals look even better after the close- Picked up another block at 15:30. Great Swing Trade.

     

    WT
    2 Jul 2014, 04:57 PM Reply Like
  • H. T. Love
    , contributor
    Comments (19491) | Send Message
     
    WWT; Sold my small start position at $7.47. Will be looking for an intra-day re-entry point. May not get it today, but I think I will.

     

    HardToLove
    3 Jul 2014, 10:23 AM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Hard: Robbins Arroyo LLP Is Investigating the Officers and Directors of Northwest Biotherapeutics, Inc. on Behalf of Shareholders

     

    http://yhoo.it/1rYsC9C
    2 Jul 2014, 02:00 PM Reply Like
  • H. T. Love
    , contributor
    Comments (19491) | Send Message
     
    Maya: Yes, I remember that's what caused the drop, no? So I started with a very small position and intended to sell calls over it. Ditto for the others.

     

    Thanks for checking and reminding, JIC in case I was not aware. It's appreciated.

     

    HardToLove
    2 Jul 2014, 02:08 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Re: (NWBO)

     

    I believe there may be more than one ambulance chasers out and about.

     

    WT
    2 Jul 2014, 02:30 PM Reply Like
  • H. T. Love
    , contributor
    Comments (19491) | Send Message
     
    WWT: That would work well - Aug. $7 strikes would give me ~10% return if I sold right now. If I'm lucky enough to catch a 2-3 day move up and then sell, get a bit more.

     

    HardToLove
    2 Jul 2014, 02:44 PM Reply Like
  • H. T. Love
    , contributor
    Comments (19491) | Send Message
     
    WWT: Reloaded that one and filled the other two at $7.32.

     

    The sell was a 1-day 4.8% RT (round-trip) scarf, fees included. Couldn't resist.

     

    HardToLove
    3 Jul 2014, 11:11 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Nice move- I took a few scalps just before the close myself. Kind of surprised that two trades were only partially filled.

     

    VERY thin market out there- take profits when they arise or possibly be sorry!

     

    WT
    4 Jul 2014, 11:04 AM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    HTL & WT:

     

    •Northwest Bio has been the subject of a massive promotional campaign which has seen the stock price soar.
    •Many of the authors involved have close hidden ties to promotional firm MDM Worldwide and / or Redfish Creative.
    •In some cases, authors have used fictitious identities and fake credentials within healthcare or finance. In fact they are simply paid writers.
    •Redfish Creative reveals its use of bulk pricing for writing undisclosed promo articles and mass message board postings on Yahoo.
    •Much of the promotional information written on Northwest has been either misleading or downright wrong.

     

    http://bit.ly/1r2ZUV2

     

    "Note: As part of his investigation, the author has shared the contents of this article along with additional materials with the United States Securities and Exchange Commission."
    7 Jul 2014, 01:42 PM Reply Like
  • H. T. Love
    , contributor
    Comments (19491) | Send Message
     
    Yikes Maya!

     

    Thanks!

     

    HardToLove
    7 Jul 2014, 01:53 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Thanks, Maya-

     

    WOW!

     

    Just as you were posting that info I was reading my SALE confirmation on (NWBO).

     

    It took a swan dive immediately after!

     

    Blind squirrels and acorns at it again!

     

    WT
    7 Jul 2014, 02:26 PM Reply Like
  • H. T. Love
    , contributor
    Comments (19491) | Send Message
     
    I got somewhat lucky - this A.M. added some for trading at $6.42 and $6.45, just off the low of $6.39.

     

    Cleared out after Maya's post at $6.61 and $6.70.

     

    Still took a bat - haven't calculated how "clean" I am yet, but it wasn't as bad as it would have been if I only had those $7.32 "reloads" I foolishly did the other day.

     

    Fortunately, all were small positions of just a few hundred shares before the additions this A.M.

     

    HardToLove
    7 Jul 2014, 03:15 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    >Maya-

     

    Re:(NWBO)

     

    I just read the whole article and checked out most of the links. What an astounding piece! It must have taken a whole lot of work to gather all that data and then to formulate and compile a fascinating read. I guess what bothers me the most is that many see no problem with this kind of activity.

     

    I quote one person that responded to the article, a comment that floored me: (identity not included)

     

    "I really only have one comment: Every biotech company uses PR firms. You connecting the dot among agencies that work together is nothing more than sensationalized yellow journalism. What you just wrote is an article on the absurdity of Yahoo Message Boards and the insanity of investing based on people writing articles on Seeking Alpha...yourself included. Good for you. No reply necessary; you clearly have no value to add. "

     

    This comment causes me to wonder about what are we all trying to accomplish? Here I thought that I was gaining knowledge- improving the breed, as it were investment wise and find that I'm just a vacuum receptacle waiting for some PR jerks to fill me up with useless Bushwa.

     

    I'm not naive enough to believe that these shenanigans didn't exist but I guess I was too naive to believe that it is a wholesale undertaking.

     

    To those that don't have a problem with this kind of activity my response is to the SEC-

     

    Go get 'em and hang 'em!

     

    WT
    7 Jul 2014, 04:29 PM Reply Like
  • H. T. Love
    , contributor
    Comments (19491) | Send Message
     
    Well, not as bad as it could have been - three accounts lost 8.8%, 7.19% and ~9%. Since I wasn't all that familiar with the stock all were small positions and losses were only two to three hundred range in each.

     

    <*sigh*>

     

    HardToLove
    7 Jul 2014, 04:45 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    WT: Toby Smith and his ilk have been for years buying stocks and then writing dramatic "this stock is set to gain 1028% in the next four months" pump pieces.

     

    I wish SA had a flag or a way to bookmark authors who write suspicious touting articles.

     

    I'm just thankful that we collectively track this crap, and in some cases can act more quickly than Joe Sixpack.
    7 Jul 2014, 04:47 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    >Maya-

     

    I really don't have a problem with Toby Smith pump syndrome. What I DO have a problem with is charlatans representing themselves as doctors, biologists, scientists of all kinds, making up lies and fabricated data and using a bundle of cash to proselytize and otherwise pump a product. That is truly evil corruption at its extreme.

     

    How do you monitor that?

     

    WT
    7 Jul 2014, 06:25 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    WT: I'm clueless. Today, SA revealed that the SCOTUS voted in favor of SA maintaining its right to have "anonymous Contributors."

     

    So it's up to SA to police the dauntless hacks.

     

    SA is VERY pleased with this ruling. I'm not so sure.
    7 Jul 2014, 07:11 PM Reply Like
  • robert.b.ferguson
    , contributor
    Comments (10491) | Send Message
     
    SA has provided a method for correcting items we take issue with. http://bit.ly/y4l9rm
    8 Jul 2014, 10:43 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    >Bob-

     

    Thanks!

     

    My problem is that we may never know that the article is bogus or have no other reason to dispute it then, unless a list of bogus authors is referenced but they would just get a new alias.

     

    WT
    8 Jul 2014, 12:43 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    >HTL-

     

    Re:(NWBO)

     

    I plan on holding out for pps of $7.50- Premium should advance smartly. I ran that setup previously.

     

    We're on the same wavelength.

     

    WT
    2 Jul 2014, 03:17 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Re:(NWBO)

     

    Sold my position on 2 July at $7.23 for a $.08 loss. I'm going to find other windmills to tilt at.

     

    Don Quixote

     

    AKA

     

    WT
    7 Jul 2014, 01:42 PM Reply Like
  • Al Marshall
    , contributor
    Comments (631) | Send Message
     
    I was also much disturbed by the Pearson article on SA about NWBO and Larry Smith, whom I follow very closely.

     

    I continued to follow the situation throughout the day and suggest Maya that you are over-reacting to a degree as much of the data appears to be false and much of the remainder appears to be stretched.

     

    If you are interested in delving further into this very disturbing mess, I'd suggest reading the comments to the Pearson article.

     

    One poster took the trouble to look up the "fictitious" authors Pearson wrote about and what they published. Most of that activity was in 2012 with some in 2013. The information they wrote about NWBO seemed to be pretty inconsequential. That is none of it seemed to be promotional in nature.

     

    Larry Smith also responded to Pearson in the comments. More powerfully, check out Smith's seeking alpha bio where he discusses his sanction by the NYSE in the late 90's.

     

    Pearson's article also includes that he is short NWBO and that he has provided support for institutions that are short the stock. He wrote that he may trade in the stock within 72 hours of publishing the article. However, Pearson did not directly state that he is out to get NWBO so I guess that means he's honest and a good guy!

     

    Adam Feuerstein also posted a comment disavowing Pearson's personal attack on Smith and claiming that Pearson hasn't published anything for the street since January of this year.

     

    I'm going to do some of my own due diligence and I'll let you all know what I find.
    8 Jul 2014, 01:24 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    >Al-

     

    Re: Due Diligence-

     

    Thanks!

     

    WT
    9 Jul 2014, 04:08 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Thanks, Al!
    9 Jul 2014, 04:33 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    FWIW-

     

    Covered CALL analysis.

     

    I hold (INO) bot at $10 and wrote a block of CALLs for $11.00- August when the stock was $9.79.

     

    Stock crossed $11 briefly and settled around $10.75.

     

    If the stock gets called in August (or before) I will pick what I got for the CALL sale $1.85 (net) reducing my cost to $8.15 for a net 35% on the stock sale minus trade costs of $42. What I call a nice 2 month return.

     

    If the stock goes higher than $11.00 I will receive no benefit of that. It will have to drop below $8.15 before I'm in the red.

     

    WT
    2 Jul 2014, 03:32 PM Reply Like
  • Mercy Jimenez
    , contributor
    Comments (2710) | Send Message
     
    FYI -- (SNTA) up 19% in 7 days. Not much news other than some exec shuffling and takeover chatter. I still hold an underwater position: http://bit.ly/1j8ytsJ
    mj
    7 Jul 2014, 10:04 AM Reply Like
  • LT
    , contributor
    Comments (5783) | Send Message
     
    NEW YORK (MarketWatch) -- Shares of BioDelivery Sciences International BDSI +15.78% are rallying 22% in active premarket trade after the company and its partner, Endo Pharmaceuticals, said a late-stage trial of its severe pain treatment met its primary efficacy endpoint. Secondary endpoints were also supportive of the treatment's efficacy. BioDelivery's stock is set to open above its all-time intraday high of $12.81 hit on June 18. Endo Pharma is a subsidiary of Endo International ENDP +0.68% .
    7 Jul 2014, 10:34 AM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » I took 10% profits in (NVAX) this morning, selling my trading block at the open. I am looking to re-purchase at 4.51. Trading Strategy? I own a single holding block and a single trading block of (NVAX). These two blocks are currently equal sized.

     

    As I have noted from time to time, I don't do well at trading. Like a good rat, I have been working on that problem.

     

    (NVAX)'s share price oscillates in the absence of news. My Trading Strategy is to take advantage of that seemingly systematic oscillation. I projected the trend of the top of the oscillations at 5.1, with a lower bound trend of 4.51. An 11.6% difference. I should have taken profits on the last trading session, but I got busy and missed it due to the shortened trading day. Bad rat, bad bad...

     

    I hope to re-purchase the trading block starting at 4.55. At this point, I don't know if I have enough information to take advantage of the projections of the next high and low trading ranges. That might be an assumption too far.

     

    By the way, (NVAX) fulfilled what I call a golden cross of the second type between June 12 and June 20. This type of golden cross occurs when the 50 day equals the 200 day MA for an extended period of time (the 50 and 200 day MAs overlap). If it had been a golden cross of the first type, I would not be taking profits at this time.

     

    What's with the different types of golden crosses? My last years failed market prediction model was based on differences between various MAs. The model was quite successful predicting market turns in the past, but mysteriously failed in June of last year. I strongly suspect that the FED's actions (QE), which have apparently acted to decrease market volatility, were responsible for that failure. Someday I might publish an article on the failure because even failed models usually contain useful conceptualizations.
    7 Jul 2014, 01:54 PM Reply Like
  • optionsgirl
    , contributor
    Comments (5202) | Send Message
     
    Ratty are you thinking of selling $4.50 puts?
    7 Jul 2014, 02:01 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    >OG-

     

    Not a bad plan selling NVAX PUTS at current prices-

     

    Served me well last go-'round.

     

    WT
    7 Jul 2014, 03:00 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    Re: NVAX PUTs

     

    Just checked 15:05

     

    Very little there-

     

    19 July $4.50P .05/.10 - 20 contracts
    16 Aug $4.50P .20/.40 - no trades

     

    WT
    7 Jul 2014, 03:05 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » I wish I could OG… I have not entered the Puts and Calls world yet… It hurts my head.
    7 Jul 2014, 03:39 PM Reply Like
  • optionsgirl
    , contributor
    Comments (5202) | Send Message
     
    You can't use July. You have to go to October.
    7 Jul 2014, 05:50 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Same for me, Rattie. Brokerage account is long, and gamer account to trade NVAX with.

     

    I'm targeting the $4.51 to $4.55 range as a reentry point, too.
    7 Jul 2014, 02:07 PM Reply Like
  • optionsgirl
    , contributor
    Comments (5202) | Send Message
     
    Well, if today is any example, you could see that reentry point as soon as tomorrow.
    7 Jul 2014, 07:26 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Yeah, OG. I'll be doing a little more TA tomorrow. Today, after 10AM, NVAX was a constant grind down all day.
    7 Jul 2014, 07:30 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    >Maya-

     

    I'd be more than willing to listen to your TA research if you want to share.

     

    WT
    7 Jul 2014, 08:09 PM Reply Like
  • Mayascribe
    , contributor
    Comments (11198) | Send Message
     
    Does that mean I have to write a melody?
    7 Jul 2014, 11:04 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (6282) | Send Message
     
    Author’s reply » Totally agree about those re-entry points OG. The rate of change is also important. There was no stock specific news, but the stock went through half its normal range today. I wonder if Richard Pearson's article moved the whole sector today?

     

    Maya, I also see no reason for SA to crow about that court victory. The SA site is being used for fraudulent purposes. SA needs to do what they can to protect the user community from fraud.

     

    One of the first things I look at with an article is the frequency of author comments. If an author is just putting out articles but not making comments, than I don't consider them as part of the social fabric of the community. If they don't make comments, than what are they here for, followers?

     

    This is not the way a social site is supposed to work. Looked at from this perspective, I propose the generation of Social Engagement Metrics.

     

    The first Social Engagement Metric consists of dividing the number of an authors comments by the number of their articles. If number of comments is a tiny number relative to the number of articles, than the author is mostly pontificating as opposed to having an active pattern of communication with the community. Any person can generate this number, but an even better number would be the number of reply’s.

     

    A second social engagement factor would be if someone comments on other peoples articles, or in our situation, on one of our news concentrators? If they don't, once again, what are they doing on the site?

     

    I think the development of social engagement metrics would be helpful in screening paid pump and dump artists. Of course to be maximally helpful, SA would need to publish social engagement metrics.
    8 Jul 2014, 12:21 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (4179) | Send Message
     
    >Maya-

     

    A simple lyrical sonnet will do!

     

    WT
    8 Jul 2014, 09:15 AM Reply Like