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  • Swine Flu, MERS, Ebola And Medical News Concentrator August 16, 2014 To September 14, 2014 258 comments
    Aug 16, 2014 2:37 PM

    This instablog is designed as an interactive News Concentrator devoted to news and discussions about Swine Flu and other medical news.

    The top portion of the instablog contains useful background information/ charts.

    Up-to-date news content is posed in the comments area. So if you are interested in current news, read the comments.

    _____________________

    Some Definitions:

    What is Reassortment

    When two different virus strains infect the same host, they often exchange genes, a process known as reassortment.

    A significant number of experts are concerned that as H5N1 (Avian Flu) spreads more widely and infects more people, it will come across more hosts who are also carrying human flu viruses. This increases the likelihood of a new strain emerging that has the severity of the bird flu virus and the infection rate of the swine flu virus, leading to a new global pandemic with much deadlier consequences than the one we are experiencing at the moment.

    What is R naught (R 0)

    How many people the average infected person infects is called the basic reproductive number, or R0 (pronounced "R naught").

    Measles, which is probably mankind's most contagious infection, has an R0 of about 18. Polio's number is about 6; severe acute respiratory syndrome (SARS) about 5. For seasonal flu strains, the R0 is about 1.2, and for pandemic strains it is rarely higher than 2. For the novel H1N1 strain, it's about 1.6. What this low R0 means is that flu outbreaks are always teetering on the verge of having their myriad chains of transmission broken by people who get infected but don't pass the virus to anyone else.

    Swine Flu - Novel H1N1 flu, popularly known as swine flu, is a respiratory infection caused by an influenza virus first recognized in spring 2009. The new virus, which is officially called swine influenza A (H1N1), contains genetic material from human, swine and avian flu viruses. (By Mayo Clinic staff)

    Pandemic - The word "pandemic" comes from the Greek "pan-", "all" + "demos", "people or population" = "pandemos" = "all the people." A pandemic affects all (nearly all) of the people.

    A World Health Organization phase 6 pandemic indicates that influenza due to the novel H1N1 swine flu is occurring in multiple countries around the world and that human infection is widespread. The classification does not reflect the severity of individual infections.

    Cytokine Storm -

    When our body detects foreign micro-organisms indicating an infection, our body might respond by over-protecting the site of infection. The body may race so many antibodies to the infection site that they collect in what is known as a cytokine storm.

    A cytokine storm, or "Hypercytokinemia" is a potentially fatal immune reaction consisting of a positive feedback loop between cytokines and immune cells.

    wisegeek.com/what-is-the-cytokine-st...

    A positive feedback loop means that as something increases, that increase stimulates further growth.

    What makes younger people more susceptible to H1N1 is that their "vigorous immune systems pour out antibodies to attack the new virus. That can inflame lung cells until they leak fluid, which can overwhelm the lungs.

    This vulnerability in the young is reminiscent of the Spanish flu of 1918. That strain of flu also struck mostly healthy young adults.

    Pulmonary Embolism - Occurs when a blood clot forms in an arm or leg breaks free and enters the lungs where it is too large to pass through the small vessels of the lungs and forms a blockage. This stops blood from flowing into an area of the lung, and the part of the lung dies because it does not receive oxygen.

    medicalnewstoday.com/articles/153796.php

    What is an Emergency Use Authorization (EUA)?

    An EUA may be issued by the Food and Drug Administration (FDA) to allow either the use of an unapproved medical product or an unapproved use of an approved medical product during certain types of emergencies with specified agents.

    What is the PREP Act?

    The PREP Act authorizes the Secretary of the Department of Health and Human Services ("Secretary") to issue a declaration ("PREP Act declaration") that provides immunity from tort liability (except for willful misconduct) for claims of loss caused, arising out of, relating to, or resulting from administration or use of countermeasures to diseases, threats and conditions determined by the Secretary to constitute a present, or credible risk of a future public health emergency to entities and individuals involved in the development, manufacture, testing, distribution, administration, and use of such countermeasures.

    The PREP Act also authorizes an emergency fund in the United States Treasury to provide compensation for injuries directly caused by administration or use of a countermeasure covered by the Secretary's declaration. While no funds have been appropriated for this purpose, if funds are appropriated, compensation may then be available for medical benefits, lost wages and death benefits to individuals for specified injuries.

    cdc.gov/h1n1flu/eua/qa.htm

    What are Clinical Trials:

    Clinical trials, also known as clinical studies, are research studies in which scientists and doctors test new drugs and treatments to see if they will improve health. Many of today's treatments for cancer are based on the results of past clinical trials. Because of progress made through clinical trials, many people treated for cancer are now living longer.

    Clinical trials are divided into four phases.

    Phase 1 trials: These trials are the first time a new drug or treatment is given to humans. They are normally carried out in a small number of volunteers (typically 6-20 people) who may include healthy volunteers or patients with the disease for which the product is intended as a treatment in order to find out how safe the treatment is. They also look at how a new drug should be given (by mouth, injected into muscle or the bloodstream, etc.), how often and at what dose. Phase 1 trials can also involve patients for whom standard therapies have failed and for whom no other therapies are available.

    Phase 2 trials: These trials involve larger numbers of people (typically 12 - 50). Phase 2 trials continue to look at safety of the therapy but also test how well the new drug or treatment works in patients with different disease types.

    Phase 3 trials: These are large studies (100+ people) that look at how well a new drug or treatment works in comparison to current therapies to see which treatment is better. Those taking part are usually divided into two treatment groups: standard treatment versus new treatment.

    Phase 4 trials: These trials are usually carried out after the drug or treatment has been approved by the FDA and is readily available for use in the general patient population. The purpose of Phase 4 trials is to continue to study the effects of the drug or treatment on different populations and to look for side effects associated with long-term use.

    Back to Top

    What is a Protocol:

    Clinical trials use written guidelines called protocols. The protocol explains what the trial hopes to accomplish, how the trial will be carried out, and why each part of the trial is necessary. For example, the protocol includes:

    * The reason for doing the trial

    * How many people will be in the trial

    * Who is eligible to take part in the trial

    * What study drugs participants will need to take

    * What medical tests participants will have and how often

    * What information will be gathered

    Every doctor or research center that takes part in the trial uses the same protocol. This makes sure that patients are treated identically no matter where they are receiving treatment, and that information from all the centers taking part can be combined and compared.

    Why Slow Production for Traditionally Produced (chicken eggs) Swine Flu Vaccine:

    One dose of swine flu vaccine for every two eggs, compared with two doses of

    seasonal flu vaccine per egg

    Sorry if the link does not work... it appears the Boston Globe newspaper appears to be playing games with link addresses... Just copy the link, and Google it.

    www.boston.com/business/healthcare/artic.../

    _____________________

    Brief Overview of Categories of H1N1/ Vaccine Investment Plays:

    I - Vaccines / Prevention

    1) Production Method / Capacity plays (NASDAQ:NVAX) (NASDAQ:VICL) (NYSE:NVS) (NYSEMKT:INO) (NYSE:CSL)

    2) Nationalistic / Population Size Play (SVA - China) (NVAX - India)

    3) Injection / Vaccine support services (syringes etc.) (NYSE:BAX) (NYSE:BDX)

    4) Outsourced production plays

    5) Bio -Defense (MDCGF - France)

    6) Anti-Mutation / Pan-Influenza Play (NYSEMKT:CVM) (NYSEMKT:NNVC) (INO)

    7) Universal Flu Vaccine Play (INO)

    II - Treatment After Infection Occurs:

    1) Dealing with severe lung infections (Fludase® (DAS181)) (NYSE:CBM) (OTCQB:OTCQB:OTCQB:OTCQB:AEMD)

    2) ICU treatments (NASDAQ:BCRX) (NYSE:GSK) (NYSE:ROG)

    III - Population Avoidance:

    1) masks/ disinfectants… Surgical masks are good enough (NYSEMKT:APT) (NYSE:MMM) (NYSE:CLX) (NYSE:ECL) (OTCQB:OTCQB:OTCQB:OTCQB:PURE)

    IV - Testing do you have it? (NASDAQ:GPRO)

    1) Test kits - (NYSE:DGX)

    V - Merger / Acquisitions / Licensing (VICL) (NVAX)

    _____________________

    Sorry this is still a graphic instead of a table. I played with the table tool, but its a

    PITA to work with.

    Swine Flu Companies Discussed and Their Web Sites

    _____________________

    Swine Flu Hits Stuffed Animal World:

    Link to 2011 H1N1 US Flu Outbreak Map is broken... sorry.

    Red Cross Tips For Dealing With The Flu:

    IF YOU ARE ILL -

    * Stay in a room separate from common areas of the home and avoid contact with others as much as possible.

    * Stay at home for at least 24 hours after their fever is gone without using medicine to reduce the fever.

    * Get lots of rest and drink plenty of fluids.

    * Consider wearing a face mask, if available and tolerable, when sharing common spaces with household members. (ed - surgical masks ok).

    * Check with your healthcare provider about whether to take antiviral medication, or if fever persists, whether antibiotics are needed.

    WHEN CARING FOR SOMEONE WHO HAS THE FLU -

    *Disinfect door knobs, switches, handles, toys and other surfaces that everyone touches.

    * Use detergent and very hot water to do dishes and wash clothes. It's okay to wash everyone's dishes and clothes together. Wash your hands after handling dirty laundry.

    * Designate only one adult as the caregiver. People at increased risk of severe illness from the flu should not be caregivers.

    * Although not mentioned by the Red Cross, the caregiver should probably ware a surgical mask as well when entering the sick room.

    * Deal with crisis situations calmly and confidently to give the best support to the person being cared for.

    _____________________

    MayoClinic.com Provides Credible, Up-to-Date Information And Decision-Support Tools For Flu Season

    Click here to link to the Mayo tool:

    mayoclinic.com/health/flu-symptoms/F...

    _____________________

    Suggested Protocol For Schools To Decide When Flu Should Trigger A Shutdown

    medicalnewstoday.com/articles/169984.php

    After comparing more than two dozen possible scenarios for closing a school, the analysis suggested three optimal scenarios:

    1. A single-day influenza-related absentee rate of 5 percent

    2. Absenteeism of 4 percent or more on two consecutive days

    3. Absenteeism of 3 percent or more on three consecutive days

    Disclosure: (sometimes trading, sometimes holding)

    Global Disease Outbreak Map

    Flu, Chikungunya, Dengue, MERS

    tinyurl.com/c8f3do

    Link from Guns and OG.

    2014 U.S. Ebola Outbreak Map and Information tinyurl.com/ll4deyw

    DoubleGuns sent us this link... Thank you Guns!

    Disclosure: I am long FTEK.

    Additional disclosure: I move in and out of Bio-Tech stocks all the time. In other words, I take profits from time to time. Of course, I also take loses…

Back To FocalPoint Analytics' Instablog HomePage »

Instablogs are blogs which are instantly set up and networked within the Seeking Alpha community. Instablog posts are not selected, edited or screened by Seeking Alpha editors, in contrast to contributors' articles.

Comments (258)
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  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » Previous news concentrator here...
    http://tinyurl.com/nj7...
    16 Aug, 02:39 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    Here's to us there's no one finer-

     

    And here's to Rattie- For all he does- For all he puts up with- For making it all better

     

    Rattie- The finest one of us all!

     

    WT
    16 Aug, 03:31 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » 17 August 2014 Ebola crisis: Protesters attack Liberia quarantine center. From: The BBC

     

    A quarantine center for suspected Ebola patients located in the densely populated West Point township of the Liberian capital Monrovia has been attacked and "looted" by protesters. A senior police officer said blood-stained mattresses, beddings and medical equipment were taken from the center and poised a serious risk. The senior police official said the looting spree threatens to spread the virus to the densely populated area. "This is one of the stupidest things I have ever seen in my life", he said.

     

    In addition, at least 20 patients [other sources have it as 30 or more] who were being monitored for Ebola have left the center. It is not known if those at the center were infected though one report suggested they had proved positive. The West Point area is densely populated with an estimated 50,000 people, and is described as a 'slum'.

     

    The protesters were unhappy that patients were being brought in from other parts of the capital and some believed Ebola was a hoax and wanted to force the quarantine center to close. The attack at the Monrovia center is seen as a major setback in the struggle to halt the outbreak, says the BBC's Will Ross, reporting from Lagos. http://tinyurl.com/kse...
    ===
    17 Aug, 03:57 PM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    This may be the tipping point that we will look back on as the point at which those in charge who may have thought they had control completely lost control. If only a few infected people make it to Lagos and infect others before being identified... it could be game over. Lagos has over 20 million inhabitants and severs as a major air transportation hub. It also is home to many multi-nationals' facilities and foreign workers. An outbreak would cause companies to close operations and bring their people home. If only a few of those going home are infected but still in the incubation phase it could get ugly worldwide fast. Just saying...
    18 Aug, 12:09 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    It's getting scary when people start attacking treatment centers. This sort of stuff is only supposed to happen in zombie movies.
    18 Aug, 03:14 PM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    I hope I'm wrong and that efforts to control this outbreak get on the front burner of governments globally. Until it does, no one is safe.
    18 Aug, 12:13 PM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    Rattie, Here is a CDC link for Ebola. I think we might get to know this site just in case. I think the info from here will be...well more reputable but always suspect anything funded by the govt. They would not want to create a panic you know......

     

    http://1.usa.gov/1AXCG8G
    18 Aug, 12:33 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    And here is the WHO page.

     

    http://bit.ly/1Buz6TM

     

    Of special note:

     

    Barriers to rapid containment of the Ebola outbreak
    http://bit.ly/1Buz9ig
    18 Aug, 03:20 PM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    Great link! Thank you. A lot of startling info but the one sentence that really got my attention was, "Some treatment facilities are overflowing; all beds are occupied and patients are being turned away."

     

    When turned away, where do patients go and with whom do they come into contact? Now that's scary!
    18 Aug, 03:30 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    And health care workers are afraid for their lives. Mortality rate even amongst them is 50%.

     

    I would not want to be there, for sure!

     

    >>
    Health-care staff fear for their lives. To date, more than 170 health-care workers have been infected and at least 81 have died.

     

    Outbreak control is further compromised when fear causes airlines to refuse to transport personal protective equipment and courier services to refuse to transport properly and securely packaged patient samples to a WHO-approved laboratory.
    <<
    18 Aug, 03:40 PM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    Rattie - You mentioned earlier that you suspect that Ebola may now be contracted through airborne methods. I had to think about that and here's what I came up with (maybe someone with better medical knowledge can correct me):

     

    When someone sneezes often some bodily fluids are launched into the air from either the mouth or nose. Those tiny particles remain airborne for only a short time unless they attach to dust particles (even then the weight draws the combined particles downward, but potentially more slowly). But those particles or droplets land on surfaces that can be touched by others' hands, etc. If the hands with the emitted body fluids contacts someone's nose, eye, or mouth interiors the virus can enter the body. Alternatively, if anyone is close enough to the infected person when they do sneeze, the tiny droplets can enter directly through eyes, ears, nose or mouth; breathing in the virus could be a form of airborne transmission. Finally, if a person sneezes near an "intake" vent of a buildings HVAC system, it is possible for the combined dust/droplets to be carried throughout the building to other rooms and taken in by others; again with the virus-containing particles landing on something or someone and being transmitted by hand to eye, ear, nose or mouth or merely by being breathed in by an unsuspecting victim.

     

    I am just wondering if anyone in this thread has enough medical knowledge to explain why this could or could not be true. I am hoping that I am wrong and would very much appreciate being corrected; if the virus is too large to be carried in that way or if it dies too quickly if left outside its host for these scenarios to have any merit, or...
    18 Aug, 03:54 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Mark,

     

    While a sneeze can propel droplets 20 feet or more (saw that graphically on Mythbusters), and could conceivably transmit Ebola that way, airborne transmission is unlikely in any other sort of situation.

     

    http://1.usa.gov/1oV1LXY

     

    It does not tend to cause a respiratory syndrome with sneezing, such as a cold or flu, but more of a gastrointestinal illness with bloody vomit and diarhea as the vectors for spread of live virus, which would then need to come in contact with open wounds or mucus membranes to be transmitted.

     

    http://bit.ly/1oV1Laj

     

    Proper isolation of the patient and careful disposal of the body fluid ejecta will prevent spread. But the uneducated people of west Africa do not understand that, and they take their sick home to nurse them instead of to a hospital with an isolation ward, coming into close contact with all that nasty stuff the sick person produces, thus spreading the disease.

     

    The virus is a rather big string-like particle, fragile and susceptible to destruction when dried, and will not survive long outside of body fluids.

     

    And, yes, I am a physician, although not internal medicine or infectious disease specialist.
    18 Aug, 04:09 PM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    Thanks, Doc. I appreciate the clarification.
    18 Aug, 04:18 PM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    WHO getting nervous and urging screening of outgoing passengers.

     

    One must not do anything to damage travel or trade however.

     

    Taken from the link below:
    "Non-affected countries need to strengthen the capacity to detect and immediately contain new cases, while avoiding measures that will create unnecessary interference with international travel or trade." WTFO!!???!! That's whats important here?

     

    http://bit.ly/1uOZOEC
    18 Aug, 05:30 PM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    Guns - The world economy is too fragile and Ebola cannot be allowed to disrupt commerce because if that happened the rich would suddenly become less so.
    18 Aug, 06:09 PM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    Mark, Obviously you are correct. I have no idea what I must of been thinking. /s
    18 Aug, 06:11 PM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    I sense sarcasm from you, as well. I hope you realize that mine was intended in the same vein.
    18 Aug, 11:14 PM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    It was very clear, of course we have known each other since 2009 I would guess. One of the old time renegades. You were a lot uglier back then. LOL
    19 Aug, 04:07 PM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    I took off the mask but did a shot from a distance. I am near the base with a couple of friends. Photo is from 5 miles out. Just kidding.
    19 Aug, 05:42 PM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    If you were near the base with friends I am sure their names would have had to have been Jack and Jim. hic*

     

    Take a trip and never leave the farm.
    19 Aug, 06:53 PM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    Yeah, they're totally out of my league. I've never been up anything over 14,320 ft. on a climb.
    19 Aug, 08:59 PM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    I made it to the top of Mount Fuji. That was enough for me. Just under 12,400 ft. We did not get the anticipated morning sun rise, it was snowing like hell. Did I mention cold. Very cold. 4th of July weekend.

     

    They say first week of Aug is the best. I have no intentions of finding out.

     

    The Japanese have a saying " A man is a fool that never climbs Mt. Fuji but a bigger fool does it twice."

     

    Since my decent I have always preferred the view of Mt Fuji from the bullet train, a plane, picture or a post card. Much easier to breath while enjoying the view.
    20 Aug, 02:15 PM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    My highest point was Blanca Peak in Colorado; we used to live about 35 miles from the base. Nothing technical to it, just a very long steep hike and a little climbing at the end (about the last 400 ft). We went up mid August and got caught in a small sleet storm that turned into snow. It's really better to make it a 2-day hike as we couldn't spend hardly any time at the top because it was already mid-afternoon and we needed to get back down before sundown. We started the day before 6 a.m. at the base.

     

    If anyone wants to go up there consider it a two-day excursion. Camp at 12,000 feet in the flat meadow just below the talus leading up to the peak. Getting to the peak before noon is important because clouds usually form in the afternoon almost every day year-round.
    20 Aug, 03:24 PM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    I forgot to mention Fuji was a 2 day excursion. We were on a Japanese tour that was half filled with Americans from the base on it. You hike up to and spend the night at station 8 first day and they wake you up around 2 in the morning to make the final ascent to be on top for the sun rise. When we left station 8 it was raining. I was with 2 Marine friends at the time and along about station 10 (when the rain changed to heavy sleet) I began to notice fragments of yellow material (poncho as we later found out) on the ground in front of me.

     

    By the time we made it to the very top in the blizzard all three of us had essentially a hood with a bib of poncho left. The rest of the ponchos got so cold they just froze and cracked apart. We looked really silly but in the dark no one could tell.

     

    We got them taken off before we ended up on TV. As we were at the Torii taking pictures and toasting with the beer we each brought in our back pack a local TV crew showed up and wanted to take a shot of us and speak to the Japanese girls with us. After our decent that night we were on the local news. The Japanese girls on the tour with us came running down to our room to get us to turn on the TV to the news channel.

     

    So I guess I have had my 15 minutes of fame.....in Japan, freezing my tail off on the top of Mt Fuji. Should have brought brandy was the thought running through my head at the time.

     

    For us the two morals of the story became "Do not buy cheap Japanese ponchos for use in very cold climates." and "Brandy is better than beer in cold climates."
    21 Aug, 07:58 PM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    Good story, Guns. I understand the point about brandy having lived in northern Wisconsin for a couple of years. They like their brandy up there. I think someone told me that if you subtract the brandy consumption of Wisconsin from the total consumption of the U.S. and compare Wisconsin with global consumption of countries, Wisconsin used to rank 5th in the world. It helps fight off cold symptoms; or at least that is what they told me.
    21 Aug, 10:01 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » Love your stories Guns!! I bet you have a million of them. Would love to hear you talking by a campfire with sufficient supplies of goodies. Hope the pain is easing a bit by now… my Aunt recently fell and hurt her back… they used some kind of glue to put it back together… The pain is completely gone!
    22 Aug, 02:01 AM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    Rattie, I feel like humpty dumpty. What glue was that. I'll take a gallon. I feel about 50% better but feel like at any moment......

     

    I am waiting for my next epidural. The surgeon wants to wait 13-16 weeks after my second set of shots to see if the disc shrinks back out of the channel where it has bulged into pinching the nerve stem. The MRI looked horrible.

     

    I decided to keep growing the beard that I got over the last month because it's very gray. Maybe looking at that every morning will convince my youthful mind that "Nooooo, your body is not 25 any more!!"
    22 Aug, 08:08 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Guns,

     

    The glue you might like best is more of a solvent - Tennessee sourmash. ;-)

     

    Seriously, there is a procedure called vertebroplasty which is used to treat vertebral compression fractures due to osteoporosis. A methylmethacrylate glue is injected into the damaged vertebra to strengthen it after injury due to osteoporosis. I don't know if that is what ails you, as you seem to be describing problems with intervetebral discs, rather than osteoporotic vertebrae.

     

    http://bit.ly/1whbotT

     

    "Vertebroplasty involves inserting a glue-like material into the center of the collapsed spinal vertebra in order to stabilize and strengthen the crushed bone. The glue (methylmethacrylate) is inserted with a needle and syringe through anesthetized skin into the midportion of the vertebra under the guidance of specialized x-ray equipment. Once inserted, the glue soon hardens, forming a cast-like structure with the locally broken bone."
    22 Aug, 10:07 AM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    Doc, my problem is a herniated disc at S1-L5. It has pushed down into the canal where the nerve stem comes from the spinal cord and goes down to my left leg. The amount of pain in that leg would seem to indicate that it was crushed from being run over by a truck however upon inspection there appears to be nothing wrong with the leg. I kept looking yet it appeared perfectly healthy.

     

    Now that will work on your mind for sure.

     

    Thankfully the epidurals worked like magic for now. My leg is no longer playing mind games on my mind.
    25 Aug, 10:23 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Ebola poses less of a risk than more contagious infections, Pittsburgh experts say

     

    http://bit.ly/1n9WBrq

     

    South Carolina physician to combat Ebola in Liberia with disinfecting robots

     

    http://fxn.ws/1n9WBrr
    20 Aug, 10:47 AM Reply Like
  • Mathieu Malecot
    , contributor
    Comments (979) | Send Message
     
    would you rather room next to Ebola or swine flu? swine flu is more contagious by far but a 50% death rate is a risk worth considering imo
    22 Aug, 11:53 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    Maya have you heard anything?

     

    (OTCQB:SBOTF) up another 6+ % today.

     

    WT
    21 Aug, 03:27 PM Reply Like
  • Mayascribe
    , contributor
    Comments (9624) | Send Message
     
    WT: Nope. A few days back, I read where touter Toby Smith was once again touting Stellar; but nothing was confirmed.

     

    I have to go back in and research if Stellar is working on hemorrhagic gastroenteritis (I think they are, but my memory is fuzzy on this matter).

     

    WHO says 70 die from illness in Congo, denies Ebola link:

     

    http://on-msn.com/XDstPw
    21 Aug, 03:33 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    Re: Stellar-

     

    Interesting to note that both Stellar and (OTCQB:ULUR) seem to go up and down in unison, and at approximately the same percentage price movements.

     

    Same investing entity in both?

     

    WT
    21 Aug, 10:00 PM Reply Like
  • Mayascribe
    , contributor
    Comments (9624) | Send Message
     
    WT: Are we back in the black permanently? Stellar up another 9% to $1.80.
    22 Aug, 04:03 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    Maya>

     

    Sure would like to think so but I see no evidence of conviction as to the rise. Very little volume and all quiet from the corp front. Maybe a subtle accumulation by those in the loop. Will try to see something in open market buys or SEC filings- possible interest from a pharma?

     

    WT
    22 Aug, 11:36 PM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    121 new deaths reported today in one day. Last report was yesterday. I suspect that all were not reported yesterday and some carried over into today's total. Even if we average the two reporting periods the average deaths per day over the last 5 days is still the highest yet at 41/day. Congo is not included, of course, since those are not considered linked to Ebola.
    21 Aug, 07:38 PM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    SOURCE: Form 4
    ISSUER: INOVIO PHARMACEUTICALS INC
    SYMBOL: INO
    FILER: COLLINS MORTON
    TITLE: Director
    DATE TRANSACTION SHARES PRICE VALUE
    8/20/14 Purchase 40,600 $9.74 $395,391
    OWNERSHIP: 173,066 (Direct) 72,625 (Indirect)
    The Form 4 is filed with the Securities and Exchange Commission by insiders
    to report transactions in their companies' shares. Open market purchases
    and sales must be reported within two business days of the transaction.
    Insider Data Source: The Washington Service
    (info@washingtonservic... or 301-913-5100)
    (NYSE:END) Dow Jones Newswires
    08-21-14 1250ET
    Copyright 2014, Dow Jones and Company, Inc. News Provided by Acquire Media Corporation
    22 Aug, 04:54 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    >LT- Thanks-

     

    (NYSEMKT:INO) back up to where writing $11s of November will be profitable once more. This stock is getting like an ATM! LOL!

     

    Now, if only (NASDAQ:NVAX) would watch and learn!

     

    WT
    22 Aug, 11:42 PM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    Picked up a couple hundred oz's of silver. This is an unusual event for it to be dropping at the end of summer. It must be manipulation. Never seen that before. /s

     

    I think I'll be paying closer attention to NEM, GDX, GDXJ, SLW, SWC and GPL of course. At least through end of year.

     

    NEM dividend is 3.75%. Precious metals can pay a dividend.
    22 Aug, 09:00 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Nice discussion of (NYSEMKT:CUR) trials and the pipeline drug NSI-189 here, about halfway down:

     

    http://bit.ly/1v4iIaR
    22 Aug, 11:21 AM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    If you guys had $10,000 to invest, what would u buy ?
    22 Aug, 11:26 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Assuming you are not limiting that 10K to biotechs, and you don't need to generate cash flow from it, I would put it into the Small Dogs of the Dow and stick that in a sock drawer for retirement.

     

    I feel this market is way overbought and the end of QE3 looms, to give us a big retraction in the more volatile techs going into the fall months. For most of my investments, my horizon is a year or more, so I am being rather cautious at the moment about buying into anything new.
    22 Aug, 12:07 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    On the other hand, if I had 10K burning a hole in my pocket I would invest it in a used BMW F800 GS with heated grips, full luggage, and knobby road rubber.

     

    http://bit.ly/1oi3uqo

     

    http://bit.ly/1wi5WqE
    22 Aug, 02:47 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    $10,000?

     

    Rather than distributing it pro-rata into my existing allocations I would put it into the AAII "Price-to-Free-Cash-Flow Screen",

     

    http://bit.ly/1oibPdq

     

    which has had an annual ten year return of 18.1%, an annual five year return of 31.3% and a return of 9.4% to date.

     

    Lets see- $10,000 at 18.1% for ten years? $52,784.

     

    Not too shabby, I would say.

     

    WT
    22 Aug, 05:45 PM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    thanks WT, I went to their site. I will look deeper later.
    22 Aug, 06:00 PM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    Biotechs With Insider Buying
    http://seekingalpha.co...
    22 Aug, 02:33 PM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    Roche to purchase InterMune in $8.3 billion deal
    http://cnb.cx/1wpqhuk
    24 Aug, 05:18 PM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    Japan ready to offer flu drug for Ebola treatment
    http://yhoo.it/1qfycoY
    25 Aug, 04:03 AM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    Aug 25 (Reuters) - Advaxis Inc <ADXS.O>: * Advaxis and Merck form collaboration to evaluate investigational combination of two novel immunotherapy candidates for advanced prostate cancer

     

    * Says Advaxis and Merck will collaborate to evaluate the adxs-psa/pembrolizumab combination as a treatment for prostate cancer

     

    * Says Advaxis will sponsor and fund the study and Merck will provide pembrolizumab

     

    * Says companies will collaboratively oversee the conduct of the study, which is planned to begin in early 2015 * Source text for Eikon [ID:nGNXVBJNZa]

     

    * Further company coverage [ADXS.O] ((Bangalore Newsroom; +1 646 223 8780))
    For Reuters Top News page click the following link:
    25 Aug, 04:33 AM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    "Current Ebola Outbreak Is Different," WHO Warns "Unprecedented" Number Of Medical Staff Infected

     

    http://bit.ly/1qbQp5Q
    25 Aug, 10:39 AM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    77 new deaths by Ebola in W Africa over last 4 days; 198 over the last 5 days; 39.6 deaths/day average. Liberia had the majority as could be expected after the looting event last week of an Ebola clinic.
    25 Aug, 01:35 PM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    The looting event could lead to an exponential increase in Liberia soon.
    25 Aug, 02:49 PM Reply Like
  • Mayascribe
    , contributor
    Comments (9624) | Send Message
     
    Another Stellar day, up over 10% again.
    25 Aug, 02:43 PM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    NVAX was up over 3.5% earlier.

     

    Edit: NOT as good as stellar however. Good job Maya.
    25 Aug, 02:47 PM Reply Like
  • Mayascribe
    , contributor
    Comments (9624) | Send Message
     
    DG: Thanks. Yeah, SBOTF is up over 280% since July 21.

     

    But like WT, I'm still up only 21 cents per share.

     

    I think Robert is back to even!
    25 Aug, 03:06 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    >Maya-

     

    This is getting scary!

     

    Another 7& today so far.

     

    WT
    26 Aug, 12:43 PM Reply Like
  • Mayascribe
    , contributor
    Comments (9624) | Send Message
     
    Wind: Quite remarkable, eh?

     

    When this run started, I figured it was some kind of short squeeze. But with the past ten days of extremely high volume, that no longer can be the case.

     

    I also contemplated that this may be some kind of Toby Smith-type pump and dump. But now, again with the recent high volume, this is unlikely the case.

     

    Someone is buying, and buying big...maybe because of a take out coming?

     

    Back when SBOTF was sinking like a lead brick, when it was dropping into the $.8x, to $.7x, and then to $.6x, I was very close to capitulating, as SBOTF was my worst performer (along with Lynas, which I did sell).

     

    I sure don't know where SBOTF is going from here, and haven't even decided my exit point, yet. Quite possibly, when SBOTF hits $3.40, I'll sell off half and go with house money. Let's just hope this run continues!
    26 Aug, 03:15 PM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    Reasons To Accumulate Shares Of Novavax
    http://seekingalpha.co...
    25 Aug, 05:10 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    Thanks, LT:

     

    I have a good chunk of (NASDAQ:NVAX) and derivates written on both PUTs and CALLs so I am sure not complaining but I feel the pop has much to do with the current hysteria about Ebola and NOT fundamentals.

     

    I believe the flurry may be ephemeral.

     

    WT
    26 Aug, 11:12 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Sold Jan 2016 $10 Calls on (NASDAQ:MNKD) today for $1.55. This lowers my basis for 1K shares to around $2. Now it can be buried in the sock drawer.
    26 Aug, 11:44 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    Way to go, Doc!

     

    If you really like the stuff sell some PUTs on it also- Maybe $7s of 26 Sept for Bid/Ask .30/.43.

     

    $400 for 31 days?

     

    WT
    26 Aug, 12:30 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    I am not yet authorized for selling puts, or I would probably try that. I have requested Schwab upgrade me to the next level for options, so I can trade puts, as well.

     

    Beginning to understand this game.
    26 Aug, 02:26 PM Reply Like
  • Mayascribe
    , contributor
    Comments (9624) | Send Message
     
    Great moves, Doc!
    26 Aug, 03:03 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    OK, I am now approved by Schwab for Level 1 options trading, meaning I can sell Puts.

     

    I am thinking of selling some in-the-money Oct14 Puts on MNKD, say the $8 Puts now asking around a buck.

     

    My thinking is there will not be huge moves up or down in the next two months, as the biggest catalysts could be 1) buyout, or 2) product on market. Buyout is unlikely, as they have already partnered with Sanofi for global licensing. Product on market is not expected until 1H 2015.

     

    If I sold 5 of the Oct $8 Puts for a buck I have lowered my cost of 500 shares to $7 if they get assigned, tied up $4K cash for two months, and potentially get the shares for cheaper than today's price of 7.50.

     

    If price rises and they are not assigned, I pocket $500.

     

    Is this sound reasoning for playing Puts in a stock I want to continue to own?
    27 Aug, 10:09 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    Doc- Re:PUT sells

     

    The way I see it you are paying an extra $.50, the difference btw the $8 and the $7.5 but only getting $.32 for the difference. Why not go for the $7.50 PUT where the ASK is $.68 vs where the ASK is $1.00 on the $8.00?

     

    Your logic is sound otherwise-

     

    IMHO

     

    WT
    27 Aug, 10:28 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Makes sense, WT.

     

    I was looking at the Oct 18th strikes, where 7.50 does not show in my screen. The Oct 3rd strikes do have a 7.50 at an ask of .62.

     

    Still considering. Thanks for the input.
    27 Aug, 10:50 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    OK, got my feet wet selling (NASDAQ:ADHD) 9/20/14 $15 PUTS x3, for 1.20. Looks like easy money.

     

    Great stock with potential catalyst of P3 reporting next month, and my shares got called away in June on $15 calls, and I would like to get back long in it, but have not with the price run it had this summer.
    27 Aug, 03:33 PM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    September Biotech Back-to-School Calendar
    http://bit.ly/1pfVxYG
    27 Aug, 03:05 AM Reply Like
  • Mayascribe
    , contributor
    Comments (9624) | Send Message
     
    LT: I always try to get my flu shot before the kids head back to school.
    27 Aug, 08:12 AM Reply Like
  • Mayascribe
    , contributor
    Comments (9624) | Send Message
     
    WT: The following is quite similar thinking to what I suggested a couple of weeks ago about the "promise" of the proximate location between Stellar and ZMapp, the maker of the anti-ebola drug (this commenter's spelling is atrocious, but I like his/hers thinking):

     

    Interesting anti-Ebola experimental drug

     

    Google ZMapp. Several articles there, including Wikipeda, that say that Mapp Biopharacudicals of San Diego,
    near Stellar, has developed an anti-Ebola drug consisiting of 3 antibodies designed to stimulate the patent's immune system. It has had varying degrees of success, somewhat dependant on how soon after being infected the patent is injected. Doesn't articulate the 3 components, but circumstancial evidence implies one could be KLH, IMO.
    It's difficult reading for the layman & there are several articles saying that everything is experimental & inconclusive, but I came away with this: It has definately saved many lives & I believe articles like these are overly
    consevative to avoid legal conflicts.
    The possibility exits IMO that because it's saving lives & making headway against this severely underestimated
    virus epidemic that "insiders", knowing that Stellar is involved are investing heavily & that, combined with the
    several new & aggresive promotional pieces, is what's driving this incredible price rise.
    HOWEVER - it's just an OPINION...please read the articles & see what you think.
    Apparently it can also be used as a vaccine to prevent being infected.
    If it does use KLH, this stock is cheap
    27 Aug, 09:16 AM Reply Like
  • Mayascribe
    , contributor
    Comments (9624) | Send Message
     
    Stellar up another 12 cents and now knocking on the 52 week high front door.
    27 Aug, 09:49 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    >Maya-

     

    Thanks.

     

    I was REALLY hoping that we would see a buyout offer but I can't complain about the pps increase!

     

    You're right-
    The stock IS cheap.

     

    WT
    27 Aug, 10:31 AM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » 27 August, 2014 - The World Health Organization (WHO) said on Tuesday it had shut a laboratory in Sierra Leone after a health worker there was infected with Ebola, a move that may hamper efforts to boost the global response to the worst ever outbreak of the disease. The WHO said it has withdrawn its' staff from the laboratory testing for Ebola at Kailahun -- one of only two in Sierra Leone -- after a Senegalese epidemiologist was infected with Ebola.
    ===
    27 Aug, 11:10 AM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    They say this one is not airborne but so many health professionals keep getting it I am beginning to wonder.
    27 Aug, 03:02 PM Reply Like
  • Mathieu Malecot
    , contributor
    Comments (979) | Send Message
     
    look at studies focused on safety practices of healthcare workers in the US and you'll find it is still very likely these incidents are the result of fluid exchange infections.
    2 Sep, 11:09 AM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    Another American Dr. gets Ebola but he was not working on Ebola patients.

     

    http://fxn.ws/1sXAwQn
    2 Sep, 03:26 PM Reply Like
  • Mayascribe
    , contributor
    Comments (9624) | Send Message
     
    My Lord. WHO expects 30 to 35% of the Haitian population will contract chikungunya:

     

    http://bit.ly/1p8SsUj

     

    I wouldn't want to fly anywhere via Port of Prince.

     

    ####

     

    SBOTF hit the 52 week high exactly, and retraced, but is still up another 3.26% today. What a different vibe about this stock as opposed to just two months ago. But now all of a sudden, we have technical analysis trading going on, simple as this might be.
    27 Aug, 03:51 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Ebola vaccine from GSK to begin U.S. clinical trials within weeks-sources

     

    Ebola vaccine from GSK to begin U.S. clinical trials within weeks-sources

     

    http://reut.rs/VPv9bt

     

    >>
    In addition, a steering committee made up of senior officials from NIH and the Department of Defense last week approved the first step toward using three advanced laboratories to manufacture Ebola vaccines and treatments, a person familiar with the planning told Reuters.

     

    The three labs, in Texas, Maryland and North Carolina, were set up in 2012 by the U.S. Department of Health and Human Services (NYSE:HHS) in partnership with private industry to respond to pandemics or chemical, biological, radiological or nuclear threats..
    <<

     

    Ebola vaccine from GSK to begin U.S. clinical trials within weeks-sources

     

    http://reut.rs/VPv9bt

     

    >>
    In addition, a steering committee made up of senior officials from NIH and the Department of Defense last week approved the first step toward using three advanced laboratories to manufacture Ebola vaccines and treatments, a person familiar with the planning told Reuters.

     

    The three labs, in Texas, Maryland and North Carolina, were set up in 2012 by the U.S. Department of Health and Human Services (NYSE:HHS) in partnership with private industry to respond to pandemics or chemical, biological, radiological or nuclear threats..
    <<

     

    NVAX is in Maryland.
    28 Aug, 06:58 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    'No Market': Scientists Struggle to Make Ebola Vaccines, Treatments

     

    http://nbcnews.to/VPxJhG

     

    A good overview of treatments being developed.
    28 Aug, 07:17 AM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    Ebola cases accelerating

     

    The World Health Organization says that the Ebola cases are accelerating.
    Forty percent of the infections have happened in the last 21 days.
    More than 20K people may be infected before the outbreak is contained.

     

    Eight companies are working on Ebola vaccines/therapies:Tek... Pharmaceuticals (NASDAQ:TKMR): TKM-Ebola in Phase 1; Sarepta Therapeutics (NASDAQ:SRPT): AVI-7537 in Preclinicals; NewLink Genetics (NASDAQ:NLNK):

     

    Ebola Vaccine in Preclinicals; BioCryst Pharmaceuticals (NASDAQ:BCRX): BCX4430 in Preclinicals; GlaxoSmithKline (NYSE:GSK): Ebola Vaccine in Preclinicals; Nanoviricides (NYSEMKT:NNVC): NV-INF-1 in Preclinicals; Inovio Pharmaceuticals (NYSEMKT:INO): SynCon DNA Vaccine in Preclinicals; FujiFilm (OTC:FUJIF) (OTCPK:FUJIY): Favipiravir in Preclinicals and Mapp Pharmaceuticals: ZMapp in Preclinicals.
    28 Aug, 07:28 AM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    I cant imagine how they could stop it if we get to 20K infections. There are not enough doctors and medical personal for something approaching that point. They would have to call in Military doctors from around the world to get enough resources to combat something that big. SCARY INDEED!!!

     

    Edit: Hope they get one of those vaccines working soon!!
    28 Aug, 08:16 AM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    Found some info on that 20K it seems they may be grandstanding to get more resources in place.

     

    "He added: "That's not saying we expect 20,000... but we have got to have a system in place that we can deal with robust numbers.''

     

    http://bbc.in/1pldG7t

     

    "Meanwhile, an international health consortium says that a trial vaccine against Ebola could be given to healthy volunteers in the UK in September, followed by trials in The Gambia and Mali."
    28 Aug, 08:23 AM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    There's already an article out where BCRX and one other company is beginning human trail this week.

     

    I would expect this is far early from what was originally planned. This explains the BCRX stock price being over priced at this point too.
    28 Aug, 08:59 AM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    here's the link:
    http://cnb.cx/VPMpNK
    28 Aug, 09:32 AM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    With several vaccines coming out for trials one would think, one....just one, might work. That would put this evil genie back in the bottle real fast for the civilized world. Now getting some in those countries people to get the shot....that would be the next challenge, while they run home with the soiled beds and linen from the infected folks at the hospital.
    28 Aug, 09:35 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Keep in mind, the trials being discussed are Phase 1&2 trials in healthy volunteers to look at tolerability and antibody response. A phase III trial is needed for FDA approval, and that will be costly, with no way to recoop the cost without massive govt subsidy (DoD).

     

    We can hope that the P1 trials will lead to a compassionate need trial in poor Africans to see if it really stops an epidemic, but who will foot the bill for that? WHO earmarked $100M for research, as I recall, but that is likely too little to do the massive vaccination campaign needed in multiple countries.

     

    Sadly, I believe isolation and containment of the epidemic remains our best short-term hope. And that will not be easy or cheap, either. Which country's UN troops are going to volunteer to police the epidemic and risk exposure themselves without a viable vaccine first?
    28 Aug, 12:02 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    Re: (OTCQB:SBOTF)

     

    Closed my position at $2.22 for 31% gain.

     

    WT
    28 Aug, 11:22 AM Reply Like
  • Mayascribe
    , contributor
    Comments (9624) | Send Message
     
    Nice gain, WT!

     

    Looks like the Stellar dump after the pump happened today. What a whipsaw day!

     

    I'm holding, only because of the fringe-ish stuff I have read about how the KLH molecule just may end up being involved with ebola.

     

    Actually, there was a nice rebound today.
    28 Aug, 04:04 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    >Maya-

     

    Thanks-

     

    Re: Stellar-

     

    Agree on the feeling that there may be a lot more to our Stellar-

     

    There should be a decent Fab retrace and I will be looking to re-enter. Reason I sold was that volume plummeted for a couple of hours while still moving up.

     

    Got hammered before when that happened.

     

    WT
    29 Aug, 08:48 PM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    125 new Ebola deaths reported on 8/28 since 8/24; average is down to 31.25 per day over that period. If the bottom doesn't go a lot lower I am afraid that the next upward surge could be over 50 per day. One other news tidbit about a new case in Lagos: "The unnamed doctor, according to news website, Sahara Reporters, secretly treated a diplomat who had contact with Patrick Sawyer, the Liberian-American, who brought the virus to Nigeria. The doctor reportedly died on Friday, while his wife had also taken ill and now quarantined in Port Harcourt. The diplomat treated by the doctor is still alive, the report said. The diplomat is believed to be among those who met Mr. Sawyer on his arrival in Lagos. He then flew to Port Harcourt where he took ill. He was treated at an unnamed hotel in the Rivers state capital, an official said."
    "This development, if confirmed will be a big blow to Nigeria’s effort to contain the deadly virus. With only one case being treated in Lagos, the Minister of Health had declared Tuesday that Nigeria had succeeded in checkmating the spread of the virus in the country."

     

    If the virus gets out of containment in Lagos it could mean... well, I don't even want to think about it.
    28 Aug, 12:55 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » I have a model now, and it's not good. It's predicting 46.5 new deaths by next week. The model uses a 50% mortality rate among several of its' assumptions. If this gets past a certain point, it will be unstoppable in Africa by medical means… You can fill in the blank there as to what would be required past that certain point.

     

    The WHO need's to move faster with more resources. Resources they don't have. I suspect one of the reasons this got out of hand is associated with a major budget shift at the WHO back in 2012. What they did was to shift the WHOs budget away from infectious diseases towards work on non-communicable disorders such as cardiovascular disease, cancer and the Messianic-like advancement of the worthless food police. #&^% !!!!!

     

    You need to take a look at how the WHO is funded and how much of the funding is discretionary and how much is earmarked. For example, the last time I looked, the second largest source of funding after the US was the Gates foundation. And all of the Gates funding is earmarked…

     

    I certainly don't mind that Gates foundation money is earmarked. What the problem here is that the governments of the world, funded by the people, are not spending sufficiently to protect the people from deadly contagious infections diseases.

     

    If this can't be done with the current WHO, than we need a new WHO.. perhaps it could be called the WIDCO, the Word Infectious Disease Control Organization. Or, even better, get the politicians out of the loop and give the money to Doctors Without Borders. Then get the hell out of the way and let them do what's needed.
    28 Aug, 02:19 PM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    FPA - I really like your suggestion of funding DWB directly and get the governments out of the way. But I think that, over time, even those who administrate that group could be tempted into self-dealing activities if the money was large enough and consistent.

     

    I think the better way is to give the a grant for maybe three years with expectations of progress on one or more fronts along with accountability on how the money was used/spent. If everything is going well at the end of the first period, then additional one-year grants could be provided as long as the progress was satisfactory.

     

    If the progress or accountability problems arise, find another organization to take over and reduce the DWB funding back to levels that allow them to do administer services as it does now, but at a better level. DWB is a great organization, but where there is ample money it will attract corruption. I feel that the ones making the contributions need to make it clear that higher funding levels will only continue to be granted as long as the money is being put to good use; and it would need to be ready to back up that statement with actions if necessary.

     

    There are just way too many charitable organization executives making mid- to high-six figure salaries. Does it really take that kind of money to get commitment from people to do the right thing? Sorry for being so cynical.
    28 Aug, 08:41 PM Reply Like
  • Mayascribe
    , contributor
    Comments (9624) | Send Message
     
    Agreed, Mark.

     

    When donating, I always check to see what the administrative expenses are. Anything over 17 to 25%, and I'll think twice.
    28 Aug, 09:16 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    Re: "Charitables"

     

    Mark and Maya- Agree all the way.

     

    One of my favorite 'soapbox' topics

     

    Some are downright obscene! Often only 15% of contributions gets to where it belongs.

     

    One of the lowest admin expense outfits is the Salvation Army.

     

    Check out the Red Cross and the United Way-

     

    WT
    29 Aug, 10:09 AM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    Yes WT I agree on that. Its amazing how Wounded Warriors has a huge over head but DAV spends soooo much more of the money they receive on the vets. Huge difference but if you have noticed wounded warriors advertises like crazy resulting in huge donations but a huge budget to pay for everything.
    1 Sep, 01:22 PM Reply Like
  • optionsgirl
    , contributor
    Comments (5057) | Send Message
     
    Hi, everyone. Look at my new avatar. WT sent it to me. Ain't I purdy? I never heard of Big Time candy before.

     

    I hope some of you took advantage of the GILD trajectory and picked some low hanging fruit. (How many metaphors can I mix in one sentence?) Look at what happened to GILD since I last wrote about it on 8/8/14:
    Date Open High Low Close
    Aug 27, 2014 106.55 108.77 105.76 107.41 16,164,800 107.41

     

    Aug 8, 2014 91.84 92.54 90.82 92.45 9,820,800 92.45
    The volume is that large number in the chart-not labelled.
    Congrats to my favorite cyber Doctor on achieving level 1 options trading. Keep going.I have level 3 authorization on Schwab, but only for taxable transactions, if it is a deferred tax account, you are at the limit--level 1.
    regards to all,
    OG
    28 Aug, 04:35 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Thanks, OG!

     

    It is a straight taxable account, but I am considering transferring an old mutual fund IRA account into Schwab to play this game. I'm learning fast, with your encouragement, and growing my account slowly as I pick up new skills.

     

    Cool avatar, and so appropriate.
    28 Aug, 04:57 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » I like your new avatar. But I would love the see the all seeing eye back from time to time. That was your original avatar as I recall.
    29 Aug, 04:09 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    >OG-

     

    Glad you like the avatar!

     

    In my tax sheltered Fidelity accounts (IRA, SEP, Roth) I am authorized to write CALLs and Naked PUTs (with cash to cover a PUT stock purchase.)

     

    WT

     

    edit:
    I'm not sure what level this is-
    29 Aug, 09:37 AM Reply Like
  • optionsgirl
    , contributor
    Comments (5057) | Send Message
     
    On Schwab's system that would be level 1, WT.
    That's because our brokers don't control that, it's another thing mandated by the government.

     

    Say guys, not to get too far afield, there are so many rumors about Romney running for president in 2016 that I might just have to dust off THAT avitar for awhile!
    29 Aug, 09:44 AM Reply Like
  • H. T. Love
    , contributor
    Comments (17431) | Send Message
     
    O.G: I think something akin to a no U-turn sign is needed implying no 47%! :-))

     

    HardToLove
    29 Aug, 11:31 AM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » Aieeeee….
    30 Aug, 02:56 AM Reply Like
  • optionsgirl
    , contributor
    Comments (5057) | Send Message
     
    Rattie, did you stick with Zalicus through the merger? How did that wind up going? It doesn't look so good to me, they seem to be down a lot, and they had a reverse split.
    Is this a buying opportunity--any thoughts on that?
    The new entity is Epirus, and it's trading on the NASDAQ.
    28 Aug, 10:25 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » Hi OG, no I sold it sometime after the announcement. I sold a lot of stocks around that time and went mostly into cash. When PSEC just recently went below book, I bought in. I followed that just yesterday with another tranche. I figured it has to go back to at least book, and in the mean time I will collect the dividends. Frankly, I could care less if the dividend goes to 10%. It's better than I have been doing lately. I just hope it gets back to book. The denizens of rat-ville are stirring because of my poor returns on their money. Back to my old cardboard box in the alley.
    29 Aug, 01:22 AM Reply Like
  • optionsgirl
    , contributor
    Comments (5057) | Send Message
     
    If the dividend drops, the stock gets dumped, that will be a good opp to get into PSEC really cheap. That's what they call a "back up the truck" opportunity.
    29 Aug, 09:49 AM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » The dividend is safe until the end of the year anyway. I think people overreacted. So the Rat moved in :)
    29 Aug, 09:52 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    .
    "the Rat moved in"

     

    Way to go Rattie- It's still a buy I believe. I may get back in- Been out since December '13

     

    WT
    29 Aug, 10:14 AM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    iBio (IBIO +2.1%) receives notices of intention to grant for two European patent applications pertaining to novel protein expression technologies.

     

    Patent app No. 05723389.2 entitled "Systems and Methods for Clonal Expression in Plants" includes claims to a system for generating transgenic hairy root cells containing a viral vector expressing a gene of interest.

     

    Patent app No. 10150887.7 entitled "System for Expression of Genes in Plants" includes claims to methods for expressing one or more polynucleotides of interest using a set of plant viral vectors that function together.

     

    Both patent apps are based on inventions made at the Fraunhofer USA Center of Molecular Biotechnology.
    29 Aug, 02:12 AM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    BioCryst receives additional funding for Ebola treatment testing

     

    Aug 29 2014, 08:58 ET | About: BioCryst Pharmaceutica... (BCRX) | By: Douglas W. House, SA News Editor Contact this editor with comments or a news tip

     

    The National Institute of Allergy and Infectious Diseases (NIAID) awards BioCryst Pharmaceuticals (NASDAQ:BCRX) a contract modification for an additional $2.4M to fund a dose ranging efficacy study of an intramuscular formulation of BCX4430 in non-human primates for the treatment of Ebola infection.
    BioCryst expects to begin testing within weeks.In September 2013 NIAID awarded a $22M five-year contract to the company to help fund the development of BCX4430.
    29 Aug, 09:00 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    This looks to be a potentially useful treatment for filoviruses.

     

    Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430

     

    http://1.usa.gov/1n3t3fx

     

    "BCX4430, a novel synthetic adenosine analogue, inhibits infection of distinct filoviruses in human cells. Biochemical, reporter-based and primer-extension assays indicate that BCX4430 inhibits viral RNA polymerase function, acting as a non-obligate RNA chain terminator. Post-exposure intramuscular administration of BCX4430 protects against Ebola virus and Marburg virus disease in rodent models. Most importantly, BCX4430 completely protects cynomolgus macaques from Marburg virus infection when administered as late as 48 hours after infection. In addition, BCX4430 exhibits broad-spectrum antiviral activity against numerous viruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses and flaviviruses. This is the first report, to our knowledge, of non-human primate protection from filovirus disease by a synthetic drug-like small molecule."

     

    Put into layspeak, that says the molecule gums up the RNA replication machinery that the virus needs to replicate itself in the host cell. If it works in monkeys to protect against lethal outcome, then it will probably be useful in humans. And not just for Ebola.

     

    I shall take a deeper look at (NASDAQ:BCRX) based on this.
    29 Aug, 10:37 AM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » (Reuters) - On Tuesday, Senegal reopened its border with Guinea over a month after it sealed land crossings with its southern neighbor to try to prevent the spread of the Ebola...

     

    And today, the Senegal health minister has confirmed its' first case of Ebola.

     

    The minister said the case was a Guinean national who had arrived from the neighboring West African country. So they opened the border on Tuesday, and four days later, the first case shows up. Based on the timing, it seems the Guinean national got in when the border was supposedly closed. Now how many contacts did this person have before getting isolated?
    29 Aug, 09:52 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Given the long incubation period of Ebola, up to 21 days, this could be a really hard epidemic to contain! Contacts would need to be quarantined for three weeks, and who is going to voluntarily put up with that when they need to put food on the table and take care of daily survival business?
    29 Aug, 10:42 AM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    Do they quarantine many folk together? Suppose someone amongst that group does have it. How would you like to be quarantined in there? I dont think they have the space to quarantine folks in private rooms so that could simply result in even more cases. They just are not equiped to deal with this issue, not with PPE or facitlities.
    1 Sep, 01:29 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    >
    Re: OG's Avatar-

     

    I was in a restaurant called The Home Front Cafe in Altamont, NY. There is a Deuce and a half out front.

     

    The place is jam-packed with memorabilia from WWII and this box was just sitting there as an exhibit so I figure it is from the mid 1040s.

     

    Couldn't pass it up.

     

    (;-)}

     

    Wt
    29 Aug, 10:19 AM Reply Like
  • Mercy Jimenez
    , contributor
    Comments (1920) | Send Message
     
    Brilliant for OG's avatar! But I think the mid "1040's" may be a little earlier in time than you meant, WT. :-)
    mj
    29 Aug, 11:41 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    >Mercy-

     

    Thanks- You're right!

     

    There weren't many cafe's back then, I'd bet; probably more though in the 1940's.

     

    I guess I have taxes on my mind! Actually it was probably a little dyslexia and my right hand thought it was my left hand on the keys!

     

    WT
    29 Aug, 02:44 PM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    Suddenly, nuclear fusion is drawing investor money
    http://cnb.cx/1n3uiLF
    29 Aug, 10:41 AM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    INO

     

    Gauging Negative Investor Sentiment
    http://seekingalpha.co...
    29 Aug, 11:31 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Sold my (NASDAQ:KYTH) when it hit upper BB just now, for a quick 12.5% in 6 weeks.

     

    Now to sell a PUT or two and get back in when it scales back.

     

    KYTH is one I ultimately want to be holding when it gets FDA approval for deoxycholic acid treatment of submental fat (double chin).
    29 Aug, 12:48 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    PS:

     

    The PDUFA date for ATX-101, the double-chin treatment, is 5/13/15, for the NDA submitted 5/13/14. I think it will be a winner, and institutions do too, with 82% ownership. But like all biotechs lately, its volatility can be played going into that date.

     

    Recent article with a brief description: http://seekingalpha.co...
    29 Aug, 01:22 PM Reply Like
  • Mercy Jimenez
    , contributor
    Comments (1920) | Send Message
     
    Thanks Doc, (NASDAQ:KYTH) is now on my watch list.
    mj
    29 Aug, 01:39 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    My pleasure, Mercy.

     

    Just to expound a bit on why ATX101 looks like a winner to me.

     

    Deoxycholic acid is a naturally occurring bile salt, produced by our livers. Bile salts dissolve fats so that they can be digested in the intestines. Kythera's approach is to use a synthetic form of the salt to inject into the "submental" fat in the double chin, with a tiny needle and a bunch of small injections.

     

    The bile salt then breaks down the fat cells and causes the breakdown products to be reabsorbed into the body and metabolized naturally through normal pathways. Voila! Melted fat cells disappear! Several treatments spaced over time can completely get rid of the double chin, without surgery or scarring, and minimal discomfort if done with a local anesthetic. Probably less uncomfortable that getting cavities filled.

     

    We have an aging population of affluent baby boomers who are vain enough to want this for their turkey wattles, so a huge potential market. It will become a fad in no time as soon as Oprah gets it done.
    29 Aug, 04:11 PM Reply Like
  • optionsgirl
    , contributor
    Comments (5057) | Send Message
     
    Why is this limited to the double chin?
    Could such an innovation potentially replace liposuction and work on love handles, as an example?
    29 Aug, 04:23 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    OG, I am betting that it can.

     

    The company needs to get it to market, and submental fat is an easy target to measure with before and after photos and skin thickness calipers, hence the first indication they are shooting for.

     

    Love handles, cellulite thighs, beer bellies, you name it. They all would respond to this approach of dissolving the fat cells with a bile salt.

     

    Once it is on market, you can bet that docs will be using it off-label to see what else can be "contoured to perfection."

     

    That is why I think the pundits have it greatly undervalued.
    29 Aug, 04:40 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    >OG-

     

    "Why is this limited to the double chin?.."

     

    What is needed now is a tightener-upper for the resulting wattles!

     

    WT
    31 Aug, 11:34 AM Reply Like
  • optionsgirl
    , contributor
    Comments (5057) | Send Message
     
    Remove fat by a simple series of injections? Everyone I know would line up!
    31 Aug, 01:25 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    WT,
    The standard chin tuck by a plastic surgeon could manage any wattle left after the Kythera product did its thing. I am guessing that with the gradual resorption of fat tissues, over the course of several months and several rounds of injections, that the natural plasticity of living skin will allow it to gradually contract and not leave a loose pouch. At least the before and after photos make it look that way.

     

    The beauty of this injection process is that it would not be limited to cosmetic surgeons. Essentially any doc could train on the procedure and do it in the office without all the surgical set up and complex anesthesia. I expect you will see dermatologists and otolaryngologists and weight loss clinics performing the procedure, if not more specialties willing to get involved in cosmetic medicine.
    31 Aug, 03:30 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    >SM-

     

    Re: Wattles-

     

    Thanks, Doc- All the women I know say that I would morph into a young stud without the wattles- Now, for that other issue.

     

    {;-)}
    1 Sep, 02:28 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » New Novartis (NYSE:NVS) heart failure drug cuts risk by a fifth.
    http://tinyurl.com/k4b...
    30 Aug, 07:34 AM Reply Like
  • D-inv
    , contributor
    Comments (3982) | Send Message
     
    The new heart failure drug looks promising (and perhaps timely for a member of extended family). Thanks, FPA.
    30 Aug, 09:24 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    The tragedy of front line research.

     

    Ebola outbreak: Five co-authors of latest study killed by virus before research was published

     

    http://ind.pn/1pYzHZp
    31 Aug, 10:19 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Ebola virus is 'mutating rapidly', experts warn

     

    http://dailym.ai/1pYBwp2
    31 Aug, 10:30 AM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » The message is clear. They need to upgrade the Personal Protection Protocol. These were highly experienced researchers who went down doing their jobs. God Bless them and the rest of the health professionals who are putting their lives on the line in an attempt to help.

     

    Apparently the outbreak was plateauing in late May, than came a funeral for a healer in Guinea. More than a dozen of the mourners contracted the disease there probably by washing or touching the body (cultural factor), and took it into Sierra Leone. It's growth exploded from that one event. It's absolutely amazing that they can track the re-emergence to one event. A lesson that apparently still needs to be assimilated by the authorities.

     

    The virus is mutating on the faster side of the normal range. Mutation is a two edged sword. It could mutate into something worse, or mutate to make it weaker. I suspect its' already mutated to something that is easer to acquire, or there is something wrong with the equipment. Has the equipment been certified? Are the deaths associated with certain equipment? Is all the equipment the same?

     

    Meanwhile, authorities have still not placed a ban on travel to and from affected countries. The idea is that all they need to do is screen people exhibiting symptoms from boarding the aircraft. Of course, if they have symptoms and are at the airport, it's already too late because they could have contacted someone without symptoms that is boarding planes. It's also possible to not exhibit symptoms and only start feeling ill on the flight, or even worse, after the flight has landed. We know the re-emergence was due to one event involving something like twelve contacts. There is nothing unusual about the number of contacts. Someone goes on a business trip, shakes hands a lot and suddenly your medical facilities are overwhelmed.

     

    The latest explanation for the lack of a travel ban is the claim that stopping aircraft will prevent medical help and supplies from coming into the countries. No, the planes land, drop the supplies off and leave. No contact. Medical staff going into the country stay in the country. People that want to come out need to go through the isolation protocol. Good luck with that as the numbers grow.

     

    British Airways has joined Gulf carrier Emirates in halting West African routes in response to the Ebola outbreak.
    31 Aug, 12:44 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    I do not recall this being mentioned here.

     

    Sanofi Bolsters Vaccine Business
    http://seekingalpha.co...

     

    Wondering about selling PUTs for (SNY). They have a solid pipeline, partnership with (MNKD), and now growth in the vaccine division.
    1 Sep, 08:21 AM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    If you want to nibble on a long shot, GERN is back in the news this fall. The writer may be onto something. I may buy 2000 shares and gamble.

     

    Geron: Best Buy In The Market
    http://bit.ly/1nR7IG9
    2 Sep, 02:57 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    I saw that article last night. It is the first article from the author, so no performance record in the SA system to judge from. He tends to use many acronyms and assume the reader understands, which is not to my taste or good writing style, and makes me wonder how much time and effort really went into the research.

     

    Nonetheless, an informative article and worth a deeper look.
    2 Sep, 07:01 AM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    May be touting GERN ahead of a capital raise too.
    2 Sep, 07:10 AM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » Thanks for the heads-up LT.

     

    I looked at the article and my primary takeaway is that (GERN) was dead in the water due to an FDA hold. They took control of the MAYO clinic data so they could prepare an anticipated blockbuster presentation at the ASH (American Society of Hematology) meeting in December. The ASH abstracts are announced in early November, so we should expect a slow ramp becoming apparent at the latest in early October. It looks to me like (GERN) needs to raise more capital for their planned multi-center Phase II trials. So they need a stock pop so they can do an offering to fund the new trials.

     

    I looked at their June 10Q. It states that existing capital resources available under their equipment financing facility and future interest income will be sufficient to fund current operations through at least the next 12 months. It also states that future capital requirements will be substantial, and they may use their available capital resources sooner than they anticipate. As of June 30, 2014, they had 300,000,000 shares of common stock authorized for issuance and 156,861,841 shares of common stock outstanding.

     

    So I see one of our wash-rinse repeat plays here. Wait for the ramp, buy; wait for the POP, sell before the inevitable offering. I would sell at 80% of the prior peak. Repeat as often as possible. I think we can make some money here.

     

    My evaluation of this play was made in terms of trading dynamics in contrast to looking at the worthiness of the drug. This is because I believe when dealing with companies who's primary means of obtaining capital is stock offerings, the underlying story about the product/ service is necessary, but not sufficient to keep the doors open. What counts to the investor under these circumstances is timing the play, all the rest is secondary. At least that's the lesson I have learned the hard-way over the past several years.
    2 Sep, 07:14 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Thanks, Rattie.

     

    I thought there was something not quite right in his story, something missing. You filled in the blanks.
    2 Sep, 07:30 AM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    You are spot on. Excellent deep analysis too.
    Expect a capital raise much sooner than many expect and maybe at lower prices too.

     

    I have followed and traded GERN just like BCRX ever since the internet came about. They are trades and not holds. Don't get greedy. Take what the mkt gives you.
    2 Sep, 08:27 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Near term options are overwhelmingly bullish for (GERN), suggesting the market expects a spike this fall. Nice premiums on a low cost stock. This may be the way to play it?

     

    WT?
    2 Sep, 09:23 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    >SM-

     

    Re:(GERN)

     

    You got my nose twitching, Doc-

     

    Sell the $2.5 Oct 18 PUT for .20
    Buy the $3.0 CALL for .15

     

    Haven't done the Risk/Reward yet but this could work.

     

    December may be more profitable but the CALL is a lot more expensive.

     

    WT

     

    EDIT:
    Sell Dec 2.5 PUT @.50
    Buy Dec 3.0 CALL @ .45

     

    Pretty good insulation on both- A move up over $3 VERY profitable.
    2 Sep, 11:12 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    Did this:

     

    Strategy Custom
    Underlying GERN
    Leg Description Action Quantity
    1 Dec 20 2014 $3 Call Buy to Open 20
    2 Dec 20 2014 $2.5 Put Sell to Open 20
    Amount Net Bid/Ask
    Net Credit $0.05 0.05/0.35

     

    Estimated Order Value $100.00
    Estimated Commission $37.95
    Total Estimated Order Value $62.05

     

    WT

     

    Worked out well>>

     

    Sold the PUTs at $.58 net
    Bot the CALLs at $.39 net
    2 Sep, 11:40 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Thanks, WT!

     

    I just did sell 10 Dec PUTs 2.5 @.51 and bought Dec 3.0 CALLs @.45.

     

    Net +$60 minus commissions in opening the trade.

     

    My first such collar trade.
    2 Sep, 11:56 AM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » WTG guys! Please let us know how that works out Doc.
    2 Sep, 12:29 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Will do!

     

    I'm learnin' summin' new every day here!
    2 Sep, 12:34 PM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    Sanofi & Regeneron

     

    Cholesterol Drug Halves Heart Attack and Stroke in Early Test
    http://nyti.ms/1lFBx1l
    2 Sep, 03:57 AM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    watch for a pop in this too: I have expected this info.

     

    Zohydro(R) ER Demonstrates Sustained 12-Hour Pain Relief
    http://bit.ly/1sWNhLb
    2 Sep, 08:34 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    I have been leery of opiates, in general, and this one in particular. While getting rid of the acetaminophen makes it safer for the liver, it has not really cut down the risk of abuse and overdose, and the DEA and state narcotics boards are going to be watching like hungry vultures how this gets prescribed.

     

    From the Package Insert:

     

    >>Zohydro ER must be taken whole, one capsule at a time, with enough water to ensure complete swallowing
    immediately after placing in the mouth [see Patient Counseling Information (17)]. Crushing, chewing, or
    dissolving Zohydro ER capsules will result in uncontrolled delivery of hydrocodone and can lead to overdose or
    death [see Warnings and Precautions (5.2)].
    Patients must not consume alcoholic beverages, or prescription or non-prescription products containing
    alcohol, while on Zohydro ER therapy. The co-ingestion of alcohol with Zohydro ER may result in
    increased plasma levels and a potentially fatal overdose of hydrocodone [see Clinical Pharmacology (12.3)]. <<
    2 Sep, 09:28 AM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    Read BCRX news today, they are doing some kinda bond default. also are reporting Peramavir flu results at a conference soon.

     

    SA won't let me do liinks ... they freeze up and page won't completely load.
    2 Sep, 09:21 AM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » September 2, 2014 - Statement by Dr. Joanne Liu, international president MSF. Delivered to a United Nations Special Briefing on Ebola http://tinyurl.com/mbb...
    ===

     

    MSF Is Médecins Sans Frontières. They are affiliated with Doctors Without Borders.

     

    My model says around 700 die this week with a total of around 1450 cumulative deaths. The latest known figure has the cumulative number of deaths at 1550. It's not plateauing ...
    2 Sep, 12:28 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Dr. Thomas Frieden, head of CDC, calling for more urgent international aid.

     

    http://usat.ly/1lGr3yF

     

    >
    "In some ways, the most upsetting thing I saw was what I didn't see," Frieden said of his trip to West Africa. "I didn't see enough beds for treatment. One facility with 36 beds, that just opened, had 63 patients. Some were laying on the ground. ... I didn't see data coming in from large parts of the country. I didn't see the rapid response that is needed to keep a single cluster from becoming a large outbreak."

     

    A separate Ebola outbreak is occurring in the Democratic Republic of Congo in central Africa. Tests on the viruses in circulation there show that the outbreak is a "distinct and independent event, with no relationship to the outbreak in West Africa," the World Health Organization said Tuesday.
    <

     

    More on the DRC outbreak:
    http://onforb.es/1sXseYT
    2 Sep, 02:22 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Here’s the current status of new drugs to fight Ebola virus and what works best now
    http://reut.rs/1sXxTOs

     

    A list of the drugs with links to the producer companies. Good resource for investing research!

     

    ---------

     

    WSJ: In Liberia, Burial Practices Hinder Battle Against Ebola.
    True Death Toll Isn't Known As Many Are Interred Secretly, Officials Say

     

    http://bit.ly/1sXxTOv

     

    >
    Ebola is ravaging Liberia, and yet nobody knows how many people the disease has killed. That epidemiological blind spot makes it especially difficult to estimate how many body bags, doctors and hospital beds West Africa will need in months to come.

     

    The World Health Organization says roughly half of the 3,069 people who have fallen ill with Ebola have died, 694 of them in Liberia. But the numbers are vastly undercounted, it says, because the true toll is buried in places like the island off this city's shore.

     

    Graves there aren't marked and don't stay visible in the sand for long. Families don't visit, and fishermen forget where they interred the bodies, none of which have been tested for Ebola....

     

    The virus is at its most infectious in the days that follow death, and that is precisely when many Liberians bury the departed, often with their bare hands.
    <
    2 Sep, 03:06 PM Reply Like
  • D-inv
    , contributor
    Comments (3982) | Send Message
     
    Question Doc. T-705 (favipiravir) appears to work by disrupting viral replication mechanism, including the ebola virus. A search for info on side effects of the drug turned up very little or than "no significant toxic effects." FujiFilm has publicly announced availability of up to 20k doses for possible Ebola treatments.

     

    Would there be a problem with health care providers treating ebola patients using favipiravir as a prophylactic hedge against becoming infected with the virus?
    2 Sep, 04:46 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    I shall have to look more closely at favipiravir, but my recollection is that it is still viewed as experimental for Ebola, with no solid human studies to document safety and efficacy.

     

    http://bit.ly/1lGHkUc

     

    This class of drugs is typically fairly benign with respect to side effects, but also typically only moderately efficacious. If it can slow virus replication a little bit, it may improve survival chances.

     

    Japan has offered to supply the drug to WHO if requested, despite lack of empirical support for Ebola efficacy.
    2 Sep, 05:28 PM Reply Like
  • D-inv
    , contributor
    Comments (3982) | Send Message
     
    http://bit.ly/1sXW0MW

     

    "Nigeria was set to receive the antiviral drug Favipiravir from Japan as a possible Ebola treatment, the Health Ministry said on Monday."
    2 Sep, 06:04 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    More about favipiravir:

     

    Ebola Drug From Japan May Emerge Among Key Candidates

     

    http://bloom.bg/1AX7hTP

     

    "The Department of Defense has prioritized the completion of a study that tests the drug called favipiravir in Ebola-infected monkeys, Derrick-Frost [DoD spokesperson] said. The drug can be fast-tracked through the regulatory review process after the studies are complete, she said. Preliminary monkey data are expected in mid-September, she said....

     

    "The advantage of using favipiravir in an Ebola outbreak is that it has already been extensively tested for use as an anti-viral in human trials for influenza. The drug is now in a U.S. final-stage trial for treating influenza."

     

    So there are human data available to the FDA for the influenza indication, and the DoD is trying to fast-track approval for Ebola based on animal data. It will not be commercialized for such without huge DoD funding, but at least information exists to allow compassionate experimental use in the Ebola epidemic. Realistically, the only customer in North America for an Ebola indication would be the DoD, but it may end up on market for influenza.

     

    Additional factoids:
    http://bit.ly/1uzO59J

     

    Effective in mice at day 6 post-infection:
    http://bit.ly/1pIglIO
    3 Sep, 08:58 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    (ACAD) moving today on news. It got special FDA Breakthrough Therapy Designation which fast-tracks approval for Parkinson's Psychosis.

     

    I expect my shares to get called away now, for a 300+% gain over the time I have owned it, traded a catalyst to reduce my basis, and sold calls.
    2 Sep, 12:40 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » NICE!!! WTG Doc!
    2 Sep, 12:42 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Acadia's pimavaserin, now trade-named Nuplazid, will be an excellent drug and unique addition to our armamentarium in treating psychosis. I have been following the story for nearly three years now, and established my initial position two years ago at $2.08.

     

    It has been one of my most successful investments, and my best pharma play to date.

     

    When the shares get called, I expect I shall get back in via PUT's.

     

    NUPLAZID should be a blockbuster as the first of a totally new category of antipsychotic, and despite the initial indication only being for Parkinson's-related psychosis, the off-label potential is huge. I have patients I would prescribe it to adjunctively to be able to lower or discontinue less-tolerated drugs.

     

    Today's press: http://bit.ly/1sXi4qY
    2 Sep, 12:52 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » At $2.08! Thud… in my dreams. I thought I was doing great with an APPL triple. Going back to my cardboard box in the alley.
    2 Sep, 12:59 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    I sold half of my initial ACAD position in April 13, when the price jumped into the 13's on early NDA news, not even imagining it would double again from there! I bought it back last fall around $23, so my average is nowhere near $2, but after selling calls, I have averaged the basis down closer to $6. The pps has been slowly ratcheting up overall in the past 18 months, as the story gets better and better with news coming out.
    2 Sep, 04:08 PM Reply Like
  • H. T. Love
    , contributor
    Comments (17431) | Send Message
     
    CNBC reports an American health care worker in Africa has tested positive for Ebola. In good spirits and health and isolation right now.

     

    HardToLove
    2 Sep, 01:07 PM Reply Like
  • optionsgirl
    , contributor
    Comments (5057) | Send Message
     
    Check out PLL (Pall Corp). Credit Suisse did a very nice write up on it. They expect it to go from $84 range to $102 w/in 18 month time frame +/-. I like the mix of biotech/pharma products and industrial. Any opinions on this company would be greatly appreciated. I am just starting DD. It also pays a modest dividend.
    http://bit.ly/1sXpXwE#
    2 Sep, 02:05 PM Reply Like
  • DRich
    , contributor
    Comments (4449) | Send Message
     
    >optiongirl ... Don't overlook that Pall is one of the world leaders in Reverse Osmosis Membranes. With water shortages & droughts all over the place there are many RO desalinization projects in the works. I'm not exactly sure this application is lumped into Industrial. It more a Utility play.
    2 Sep, 02:12 PM Reply Like
  • Mercy Jimenez
    , contributor
    Comments (1920) | Send Message
     
    OG I've had these guys on my watch list because I like their water filtration capabilities. I am a buyer if the price drops to mid-high 70's.
    mj
    2 Sep, 02:15 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » Pall Corporation - (PLL) filters everything.

     

    I see a death cross in early August. So short term share price is weaker than the 200 day historical average. They are supposed to be recession proof. I doubt that. From their annual report, I see they have a lot of exposure to Europe and Asia to the tune of 39 and 29 percent of sales. Given the economic situation in Europe, I expect decreases or stagnation in revenues there, not growth.

     

    They can of course resort to the usual procedures of cost cutting, but you can only go so far with that. I almost stopped at this point, but I also ran into a statement that they are focusing on growth in emerging markets. I think that's a pretty speculative bet from what appears to be a somewhat conservative company. At this point, I stopped looking.

     

    Given the weight of income dependence on Europe and Asia, I suspect growth is going to stagnate and not return until Europe gets its giddy-up back. Alternatively, they could have a significant product break-through, but no way to know about something like that. I have doubts about focusing their growth strategy on emerging markets. That leaves cost cutting as the means to increase the bottom line. I feel you can't run a company like this with accountants. The dividend is 1.4%. They have nearly a Billion in cash, but they also have nearly as much in debt.

     

    Of course, this is just how I read the tea leaves and you know how well I have been doing relative to others lately; having been banned to the cardboard box in the alley with no heat. Everyone needs to do their own DD.
    3 Sep, 12:24 PM Reply Like
  • Mercy Jimenez
    , contributor
    Comments (1920) | Send Message
     
    Great observations, FPA, all valid IMO. When I was looking for increased exposure to "water" players I elected to grow a position in (MWA) Mueller rather than (PLL) and others unless the pps becomes irresistible.
    mj
    3 Sep, 01:35 PM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    It appears there are two strains of Ebola floating around Africa now.

     

    http://bit.ly/1lGDpa4
    2 Sep, 04:45 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    The strain in DRC is different genetically from the one in West Africa, but they probably both came from the primate "bush meat" reservoir in the wild. Nobody knows how many strains might actually exist in the jungle animals.

     

    The DRC strain outbreak was traced to a woman who butchered bush meat her husband had killed.
    2 Sep, 05:31 PM Reply Like
  • Mayascribe
    , contributor
    Comments (9624) | Send Message
     
    R2D2 to the rescue?

     

    This new robot goes into a room and zaps pathogens with xenon light so strong it's 20,000 times brighter than the sun (it will not work if someone is in the room).

     

    Proven effective against c.diff, MRSA and 22+ pathogens. Published in ICHE, AJIC and Journal of Infection Prevention. - See more at: http://bit.ly/1lGFxyy

     

    Using a variety of methods, high-energy ultraviolet light in the area of the spectrum known as UV-C is produced by either mercury or xenon gas lamps. This UV-C energy passes through the cell walls of bacteria, viruses and bacterial spores. Once the UV-C energy is inside the microorganism, it is absorbed by the DNA, RNA and proteins. One of the primary mechanisms of damage created by UV-C is the fusing of the strands of DNA creating what is known as “thymine dimers.” Once the DNA is fused, the organism can no longer replicate and is, therefore, no longer infectious. The technical term for this is “deactivation.” - See more at: http://bit.ly/1lGFxyz

     

    http://www.xenex.com
    2 Sep, 05:10 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Does it squeak and squeal, or does it say "Danger, Will Robinson! Danger!"

     

    It is definitely armed with a Ray Gun!
    2 Sep, 05:37 PM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    Sanofi Dengue Vaccine Works on All Four Types in Study
    http://bloom.bg/W9N2Bv
    3 Sep, 04:29 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Can Ebola Go Airborne?

     

    http://onforb.es/1t03eAa

     

    Here is an excellent discussion of the scientific reasons for the "NO" answer I posted last week.
    3 Sep, 11:54 AM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    Doc, thanks for another sigh of relief.

     

    I just heard that the new US doc that came up positive was removing his PPE because it was too hot. That is utterly shocking to me. Like not wearing body armor in combat because its to hot.

     

    Lunatic comes to mind.
    3 Sep, 06:41 PM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    Nurse strike will not help things along but I would not go to work there without proper PPE either. Of course if there are no more health care workers getting infected this problem might slow down.....assuming it has not gone to far already.

     

    http://bit.ly/1t1pf1s
    3 Sep, 06:58 PM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    Infiniti and Roche ink supply agreements

     

    The two firms sign a master clinical supply agreement whereby Roche (OTCQX:RHHBY +0.7%) will supply Gazyva (obinutuzumab) to Infiniti Pharmaceuticals (INFI +46.2%) for use in planned clinical studies to evaluate the combination of Gazyva and IPI-145 (duvelisib) as a treatment for patients with blood cancers.

     

    The companies also consummate a material transfer agreement whereby Infiniti will supply IPI-145 to Roche to use in its preclinical and translational research to evaluate the combination of duvelisib and Gazyva.
    4 Sep, 04:34 AM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    Abbvie has 2 big partnerships this week:

     

    Google Healthcare Startup Calico Partners With Abbvie
    http://bit.ly/1tvtsyz

     

    Infinity Pharma Snags Abbvie for Blood Cancer Drug Partnership
    http://bit.ly/1tvtuX0
    4 Sep, 05:10 AM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    This really needs to be good: Sat. & Sun. Sept 6 & 7th

     

    Novavax to Present RSV Vaccine Clinical and Preclinical Results at ICAAC
    http://bit.ly/1t2Y0Un
    4 Sep, 05:13 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Slide Session Number 077: I-649. "Immunization of Pregnant Baboons with the RSV F Nanoparticle Vaccine Protects Infant Baboons Challenged with Respiratory Syncytial Virus in a Comparable Manner to Infants Prophylaxed with Palivizumab"
    [Meeting Room 209A, Sunday, September 7, 2014 from 8:45 to 9:00 am]

     

    The title gives it away. This is a positive animal study that should pave the way for human phase I trials.
    4 Sep, 07:13 AM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » Nice one Doc! Thanks very much for that link LT!
    4 Sep, 07:30 AM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    Inovio Pharmaceuticals to List on NASDAQ
    http://bit.ly/1qg1ODw
    4 Sep, 09:20 AM Reply Like
  • D-inv
    , contributor
    Comments (3982) | Send Message
     
    Interesting development, LT.

     

    "will transfer its U.S. stock exchange listing from the NYSE MKT to the NASDAQ Global Select Market on September 15, 2014."

     

    Leaving the NYSE for NASDAQ. May have happened many times but there was a time when NYSE listing was considered top rank.
    4 Sep, 05:47 PM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    (GERN)

     

    Trading up 6+ % on over 1,000,000 shares-

     

    Anyone hear anything?

     

    WT
    4 Sep, 10:28 AM Reply Like
  • Windwood Trader
    , contributor
    Comments (2506) | Send Message
     
    Re: (GERN)

     

    Last [Tick] $2.585 [+]
    Change Up $0.145
    % Change Up 5.94%
    Volume 3,361,163 Abt average

     

    WT
    4 Sep, 05:36 PM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    This is not good!

     

    Abia Declares Manhunt for 50 Suspected Ebola Victims Who 'Escaped ... - Nigerian Bulletin http://bit.ly/1qgMkPz
    Nigerian Commisioner for Health, Mr. Okechukwu Ogah said that the Abia State Government will "'work with neighbouring states to track down the 50 people that were said to have fled from Rivers State and put them on surveillance. We need to work together to rid Nigeria of Ebola; and if there is anybody hiding in Abia we will ask for their names and announce them on air for the public to help us track them.'"
    4 Sep, 12:31 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Here is a good discussion of two of my favorites, (CEMP) and (TTPH).

     

    http://seekingalpha.co...
    5 Sep, 07:26 AM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    FDA clears Keryx's ferric citrate, trading halted

     

    The FDA approves Keryx Biopharmaceuticals' (KERX -6.2%) ferric citrate (formerly Zerenex) for the control of serum phosphate levels in patients with chronic kidney disease on dialysis.

     

    Keryx CEO Ron Bentsur says, "We are thrilled with the FDA's decision to approve ferric citrate and look forward to bringing it to market in the U.S. within the next 12 weeks.

     

    "The FDA recently informed the company that its approval of the brand name Zerenex was rescinded. A new brand name will identified on or prior to launch.
    5 Sep, 12:16 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Many in West Africa May Be Immune to Ebola Virus

     

    http://nyti.ms/1teeZD2

     

    Their blood and serum products might be useful treatments.

     

    ----------------------...

     

    Two Vaccines to Protect Against Ebola Could Be Available Within Weeks

     

    http://nyti.ms/1teftJu

     

    >
    The pace of testing, and the bypassing of normal protocols to develop the vaccines, is “absolutely unprecedented,” Dr. Kieny said. She said that the vaccine testing protocol was approved in Mali within days and that there had been a “change of all the processes that we know, for this particular Ebola outbreak.”

     

    While it was likely that patents had been filed and intellectual property rights applied to some of the vaccines and treatments, she said, “so far we’ve seen absolutely no problem and no barrier to the use of these.”

     

    .....

     

    W.H.O. officials recently estimated it would cost $600 million to fight the Ebola scourge, the worst in the nearly 40-year history of the disease, and that 20,000 people could be infected before it is brought under control. “One of the things driving fear and panic in the communities and the world is the belief there is no treatment,” Dr. Kieny said.
    <
    6 Sep, 04:03 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Novavax Presents Data on RSV F Nanoparticle Vaccine Induced Monoclonal Antibody at ICAAC

     

    http://on.mktw.net/1te...

     

    "...preclinical data demonstrating that antibodies generated to its RSV F-protein nanoparticle vaccine candidate (RSV F vaccine) bind to the site II epitope of the RSV F-protein with a higher affinity than palivizumab (Syangis®) at the 54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in Washington, DC."

     

    Good news from the mouse model. Thank Rattie's cousins!
    6 Sep, 04:22 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    For those seeking a catalyst driven trade next week.

     

    Orexigen Gets Weight Loss Drug Patent, May See Runup Into Approval Decision

     

    http://bit.ly/1lOt63O

     

    FDA approval is pretty much a done deal at this point.
    6 Sep, 09:37 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » Ahhh!!! Thank you Doc!
    7 Sep, 12:58 AM Reply Like
  • D-inv
    , contributor
    Comments (3982) | Send Message
     
    Thanks, Doc. Dipped a toe in OREX waters.
    8 Sep, 03:27 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » Me too!
    8 Sep, 03:39 PM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    i bought a few shares too...ty SM
    8 Sep, 03:47 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    (OREX) moving today on tomorrow's news.

     

    FDA Expected To Approve Two More Weight Loss Drugs
    http://bit.ly/WIHOgh
    10 Sep, 10:11 AM Reply Like
  • Mercy Jimenez
    , contributor
    Comments (1920) | Send Message
     
    Protalix (PLX) an Israeli biotech company jumped today (Sunday) after reporting "that its technology could be used to develop an Ebola treatment similar to the experimental drug ZMapp, which has shown promising results in recent trials ... Protalix's facility in northern Israel is one of the only places in the world with the technology to mass produce a medicine like ZMapp, which uses antibodies from tobacco plants ... The company's chief executive told Reuters that while future collaboration with the manufacturer of ZMapp was possible, it was still purely theoretical." http://reut.rs/1qxwwHT
    mj
    7 Sep, 09:08 AM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    I realize that this is not the case, but wouldn't it be ironic if chewing tobacco was found to build up immunity to Ebola? LOL
    7 Sep, 04:09 PM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    Total deaths from Ebola as of Sept 5, 2014 = 2,014. Average number of deaths over the last 8 days is 69.13.

     

    This is the highest peak so far.

     

    WHO has announced the expectation of 20,000 deaths from Ebola before the epidemic is over.

     

    I am now buying into the concept that the vaccines (more so than cures) could become big sellers if offered to the public shortly after the first confirmed cases are reported in the U.S.

     

    Question is: Will the government step in and make the vaccines unprofitable or will it buy up the vaccines and decide who gets them? Officials still have a huge opportunity to screw this up either way.

     

    If they just get out of the way and let the market decide, then the poor and homeless could be at risk if uninsured. Wouldn't that make a big story against capitalism?

     

    There is probably a happy medium that could protect nearly everyone, but my confidence level is not very high with government intervention.
    7 Sep, 03:59 PM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    Interesting article about majors in the mix for Ebola vaccine:

     

    http://yhoo.it/1AnHd14
    7 Sep, 04:07 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » Informative article! Thanks Mark.
    7 Sep, 10:07 PM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    Unidentified Respiratory Virus Likely to Hit Kids Across Country
    http://abcn.ws/1rT2OzN
    8 Sep, 02:53 AM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » Only kids get it?
    8 Sep, 09:09 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    I doubt it is limitied to children, but the article seems to imply that they are at greater risk and younger or asthmatic kids may be more vulnerable to severe disease.

     

    It may be that adults are more likely to have cross-immunity from some previous exposure to a similar enterovirus. Most enteroviruses cause gastrointestinal disease, rather than a primarily respiratory syndrome, although a mixed picture of upset stomach and mild cold symptoms is common, and we have all had "stomach bugs" many times from such.

     

    PS:
    Here is another article with a good explanation:
    http://cnn.it/1lNezFe

     

    Medscape article based on a 2011 CDC Morbidity and Mortality Report:
    http://bit.ly/1lNezFg

     

    "CDC has learned of several clusters of respiratory illness associated with human enterovirus 68 (HEV68), including severe disease. HEV68 is a unique enterovirus that shares epidemiologic and biologic features with human rhinoviruses (HRV).[1] First isolated in California in 1962 from four children with bronchiolitis and pneumonia,[2] HEV68 has been reported rarely since that time and the full spectrum of illness that it can cause is unknown. The six clusters of respiratory illness associated with HEV68 described in this report occurred in Asia, Europe, and the United States during 2008–2010. HEV68 infection was associated with respiratory illness ranging from relatively mild illness that did not require hospitalization to severe illness requiring intensive care and mechanical ventilation. Three cases, two in the Philippines and one in Japan, were fatal. In these six clusters, HEV68 disproportionately occurred among children. "
    8 Sep, 10:02 AM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Here is the full MMWR from the CDC that first described the virus epidemic pattern:

     

    Clusters of Acute Respiratory Illness Associated with Human Enterovirus 68 --- Asia, Europe, and United States, 2008--2010
    Weekly
    September 30, 2011 / 60(38);1301-1304

     

    http://1.usa.gov/1we3UUG
    8 Sep, 10:14 AM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » September 8, 2014 - The World Health Organization says one of its doctors has been infected with Ebola while working at a treatment center in Sierra Leone. This is the second time a health care specialist working with the U.N. agency has been infected with the disease. A Senegalese epidemiologist was also infected working in a lab located in Sierra Leone and is being treated for Ebola in Germany. http://tinyurl.com/ol4...
    ===
    And another highly trained health official gets infected. That doctor in the field had to be using WHO provided Personal Protection Equipment [PPE].
    8 Sep, 02:49 PM Reply Like
  • SMaturin
    , contributor
    Comments (2190) | Send Message
     
    Breaking news: Liberia's Ebola problem far worse than imagined, says WHO

     

    http://bit.ly/1welc4f

     

    Very beautiful electron microscopy image of the deadly virus, as well as an admission by WHO that resources are overwhelmed and a great deal of extra help is going to be needed.

     

    Obama has announced our troops will be helping set up facilities and provide security. I hope they are getting the experimental vaccine first!

     

    http://fxn.ws/1weljg6
    8 Sep, 04:37 PM Reply Like
  • FocalPoint Analytics
    , contributor
    Comments (5853) | Send Message
     
    Author’s reply » The boots on the ground have been screaming about this for weeks…. The statistical models were saying Exponential growth weeks ago. Now it has a good sized base of infected people without symptoms spreading it. The greater the base, the more draconian the needed response in terms of stopping it. Deadly force has already been applied… expect more of that as the fear grows. The WHO need to be overhauled with respect to control over its budget. If that can't be done, than the world needs to fund a new international health organization.
    8 Sep, 05:19 PM Reply Like
  • doubleguns
    , contributor
    Comments (7940) | Send Message
     
    Doc I am wondering how many of our troops end up coming back infected or with dirty laundry or some other item maybe purchased as a souvenir containing that virus. How long will it last out side of the body?

     

    I feel that this could be the spanish flu all over again. I am sure we are not the only country to send in troops to help out that could actually help with the globalization of this disease. What pray tell is wrong with the military from those infected countries stepping forward. How many trials will we have if our troops shoot someone over there.

     

    uggggggggg do we have to fight every terroist, cockroach and infectious bug on the face of the earth for eveyone else is all that keeps coming to mind!!! Whos is going to foot the bill. Wonder if these costs will be added into the 5 billion BO is asking for to fight ISIS.

     

    Anyone think the Chinese will loan us the money?
    8 Sep, 06:28 PM Reply Like
  • LT
    , contributor
    Comments (4712) | Send Message
     
    ahhh DG, don't worry about paying for it...it's just money. They can print as much as they want.

     

    Virus' rarely live outside the body over a few hours. Bleach and sunshine is deadly to most of them.
    8 Sep, 07:22 PM Reply Like
  • D-inv
    , contributor
    Comments (3982) | Send Message
     
    " Bleach and sunshine is deadly to most of them. "

     

    :-) Been thinking about buying CLX. Now have another factor to consider.
    8 Sep, 07:26 PM Reply Like
  • Mark Bern, CFA
    , contributor
    Comments (4781) | Send Message
     
    I like CLX except for the debt ratio. But they managed through the last financial and nobody is going to stop using the product, so....
    8 Sep, 11:31 PM Reply Like