MissionIR's  Instablog

Send Message
We know our reputation is based on the integrity of our clients and go to great lengths to ensure the companies represented adhere to sound business practices. It is our unwavering commitment to connect the investment community with companies that have great potential and a strong dedication to... More
My company:
My blog:
MissionIR Blog
  • New Data To Be Presented On The Impact Of Prana Biotechnology Ltd. (PRAN) Lead Drug Candidate 0 comments
    Mar 7, 2013 3:01 PM | about stocks: PRAN

    Today, Prana Biotechnology Ltd. announced that its lead drug candidate for Parkinson's disease and movement disorders, PBT434, will be presented at two international conferences this month, reporting the key finding that PBT434 reduces the aggregation and accumulation of a key protein (alpha-synuclein) in multiple transgenic animal models of Parkinson's disease.

    The alpha-synuclein (s.n.) protein aggregates inside the nerve cells of the substantia nigra, which is the part of the brain responsible for controlling movement and the part of the brain that is progressively damaged in Parkinson's disease. The (s.n.) protein aggregates are linked with the onset and progression of Parkinson's disease, and PBT434 significantly prevented the death of substantia nigra brain cells in three different Parkinson's disease animal models.

    "A treatment for Parkinson's disease and other movement diseases that actually modifies the course of the diseases remains a major unmet medical need," said Robert Cherny, an associate professor and the head of research for Prana. "Our data suggests that PBT434 intervenes in metal dependent pathways which otherwise promote the aggregation of alpha-synuclein. Thus, PBT434 prevents the death of substantia nigra cells. We have observed marked improvements in motor function and coordination with PBT434."

    Presenting the new data at the 11th International Basal Ganglia Society Meeting - March 3-7 in Eilat, Israel - will be Associate Professor David Finkelstein. He will present a talked entitled "PD: Towards New Disease Modifying Therapies."

    Additionally, Associate Professor Kevin Barnham will discuss PBT434 at the 11th International Conference on Alzheimer's and Parkinson's disease, March 6-10 in Florence, Italy. His presentation will be entitled "The Role of Nitrated Tau in PD."

    Prana is developing PBT434 with support from the Michael J. Fox Foundation for Parkinson's Disease Research.

    For more information about Prana Biotechnology, visit www.pranabio.com

    Sign up for "The Mission Report" at www.MissionIR.com

    Stocks: PRAN
Back To MissionIR's Instablog HomePage »

Instablogs are blogs which are instantly set up and networked within the Seeking Alpha community. Instablog posts are not selected, edited or screened by Seeking Alpha editors, in contrast to contributors' articles.

Comments (0)
Track new comments
Be the first to comment
Full index of posts »
Latest Followers


More »
Instablogs are Seeking Alpha's free blogging platform customized for finance, with instant set up and exposure to millions of readers interested in the financial markets. Publish your own instablog in minutes.