Isis heart drug helps cut blood fat in trial

|By:, SA News Editor

Isis' (ISIS) ISIS-APOCIIIRx reduced levels of triglycerides in blood by up to 75% and of apolipoprotein C-III by 79% in a Phase II study of 28 patients.

Triglycerides are a type of fat that raises the risk of heart disease, while apolipoprotein C-III prevents triglycerides from being cleared.

Patients also enjoyed increases of up to 57% in high-density lipoprotein (HDL), or "good," cholesterol.

ISIS-APOCIIIRx is based on Isis' antisense technology, which inhibits cells from producing proteins that cause diseases. (PR)