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Merrimack's MM-121 misses primary endpoint, shares slide

Merrimack Pharmaceuticals' (MACK) MM-121 misses its PFS primary endpoint in a Phase 2 trial evaluating the treatment in combination with paclitaxel versus paclitaxel alone in patients with platinum-resistant or platinum-refractory advanced ovarian cancers.

Hazard Ratio was 1.

The company says "ongoing analysis of a pre-specified set of biomarkers mechanistically linked to ErbB3 signaling identified a potential subpopulation of patients benefiting from MM-121 treatment in combination with paclitaxel."

In the group receiving the combination therapy, there was "an overall increase in all grades of gastrointestinal toxicities." (PR)

MACK -12% premarket.

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