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Glaxo pulls the plug on lupus drug development

  • GSK (GSK) has called it quits on its GSK2586184 treatment for lupus - which it's developing with Belgian biotech Galapagos (GLPGF) - after a Phase 2 study failed to demonstrate a positive effect. A Phase1/2 trial for ulcerative colitis was put on hold as well, although dosing in a Phase 2 trial for the skin condition psoriasis has just been completed.
  • Galapagos' relationship with Glaxo goes back seven years and included $300M in potential milestone payments. Galapagos was in line for a $34M payment for the start of the Phase 2 study.
  • Glaxo's decision over lupus shows its willingness to end development that's not working - last year, the company pulled the plug on ChemoCentryx's Vercirnon, abruptly ending a $1.5B collaboration after a Phase 3 trial failed. (PR)
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