Seeking Alpha

Synergy's IBS drug delivers positive top-line results in mid-stage trial

  • Synergy Pharmaceuticals' (SGYP) plecanatide shows a statistically significant improvement in complete spontaneous bowel movement (CSBM) frequency in patients with irritable bowel syndrome with constipation (IBS-C) in a Phase 2b clinical trial.
  • Patients also experienced a statistically significant improvement in change from baseline versus placebo in worst abdominal pain and met the FDA overall responder endpoint for IBS-C over the 12-week treatment period.
  • The company plans to start a Phase 3 trial in the second half.
  • Shares are up 5% premarket on robust volume.
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