Seeking Alpha

Alnylam up premarket on monkey study

  • Certain traders are apparently swinging from trees this morning as they pop shares of Alnylam (ALNY8% on modest volume in premarket action in response to its announcement of a significant reduction in HBV surface antigen in preclinical testing on four monkeys with its RNAi therapeutic ALN-HBV product candidate. The product reduced HBsAg as much as 2.3 log10 compared to 0.5 log10 which is the generally accepted minimum reduction indicating immunologic cure. While encouraging, a colossal amount of work  and time remains before any such product will reach the market.
  • Alnylam purchased the assets from Merck (MRK) in January for $175M ($25M cash + stock). Merck acquired the assets via its acquisition of Sirna Therapeutics in 2006 for $1.1B. Merck's exit at a significant loss is a clear signal that the road to commercialization will be long and arduous.
  • Alnylam hopes to file an IND by the end of 2015.
Comments (1)
  • TruffelPig
    , contributor
    Comments (4097) | Send Message
     
    There is a Nature paper too: http://bit.ly/1oJ1RnT
    12 May 2014, 01:29 PM Reply Like
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