NEJM publishes POC data for Amgen mAb for asthma

|About: Amgen Inc. (AMGN)|By:, SA News Editor

The New England Journal of Medicine publishes the results from a 31-patient 12-week Phase 1 proof-of-concept study of Amgen's (AMGN +0.1%) AMG-157 mAb for asthma. The study's conclusion is that AMG-157 reduced allergen-induced bronchoconstriction and indexes of airway inflammation before and after allergen challenge. The results are statistically significant.

AMG-157 is a monoclonal immunoglobulin IgG2 that is a thymic stromal lymphopoietin (TSLP) inhibitor. TSLP is a cytokine thought to have a major role in allergic inflammation.

The product candidate is one of five mAbs from Amgen's inflammation portfolio that it is developing with AstraZeneca (AZN +2.2%).