- In a 1,800-patient Phase 3 clinical trial comparing Zinbryta (daclizumab) to Avonex (interferon beta-1a) in patients with relapsing-remitting multiple sclerosis (RRMS), Zinbryta demonstrated a statistically significant improvement in reducing disease activity by virtue of a 45% reduction in annualized relapse rate (p=0.0001).
- Select secondary endpoints: the Zinbryta group demonstrated superiority in reducing the number of new or newly enlarging T2-hyperintense lesions at week 96 (54% reduction compared to Avonex), 73% were relapse-free at week 96 vs. 59% for Avonex and the risk of meaningful worsening in the physical impact of MS was reduced 24% compared to the Avonex cohort.
- Development partners Biogen (NASDAQ:BIIB) and AbbVie (ABBV) plan to submit regulatory applications for Zinbryta in 1H 2015.