- Micro cap Neuralstem (CUR) is up 11% premarket on light volume in apparent response to its announcement of a poster presentation at the International Society for Stem Cell Research Annual Meeting in Stockholm, Sweden.
- The poster, "Human Neural Stem Cells Expressing IGF-1: A Novel Cellular Therapy for Alzheimer's Disease," (AD) was presented by researchers from the University of Michigan. Mice with an animal model of AD were transplanted with HK532-IGF-1 cells in the peri-hippocampus. They performed better on hippocampal-dependent behavioral tasks than untreated mice which demonstrated enhanced learning cognitive processes and memory consolidation. There was also a reduction in beta-amyloid plaques in both the cortex and hippocampus of the treated mice. Amyloid plaque is one of the two hallmarks of AD.
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HK532-IGF-1, the company's second stem cell line, is a proprietary line of cortical neural stem cells engineered to express insulin-like growth factor-1, which has demonstrated wide-ranging neuroprotective properties. Its development is ongoing.