- Cerulean Pharma (CERU +2.9%) completes enrollment of 110 subjects in a randomized Phase 2 clinical trial evaluating lead product candidate CRLX101, in combination with Roche's (OTCQX:RHHBY +1%) Avastin (bevacizumab), in third- and fourth-line relapsed renal cell carcinoma (RCC). The primary endpoint is progression-free survival per RECIST 1.1 criteria. Top-line data are expected in H1 2016.
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CRLX101 is a nanoparticle-drug conjugate which is designed to concentrate in tumors and slowly release the cytotoxin camptothecin.