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Results from a Phase 1b study show Roche's (OTCQX:RHHBY) investigational cancer immunotherapy candidate atezolizumab (MPDL3280A), in combination with Zelboraf (vemurafenib), produced a significant treatment effect in patients with previously untreated BRAF-positive unresectable or metastatic melanoma. In 17 patients, the objective response rate was 76% (n=13/17), including three complete responders. The data were presented at the Society of Melanoma Research 2015 International Congress in San Francisco.
- Objective response rate includes complete responders, partial responders and those with stable disease (progression-free).
- No dose-limiting toxicities or atezolizumab-related treatment discontinuations were observed, although staggering the dosing of atezolizumab and Zelboraf after Zelboraf run-in was better tolerated that concurrent dosing. The incidence of Grade 3 (severe) adverse events (AEs) related to atezolizumab and Zelboraf was 41% and 59%, respectively. Treatment-related AEs included pyrexia (high fever) and dehydration.
- Atezolizumab is a PD-L1 inhibitor while vemurafenib is a kinase inhibitor.
- The company's development of the combination is ongoing.