The FDA says that the blood thinner Pradaxa is not safe for use on patients with mechanical...

The FDA says that the blood thinner Pradaxa is not safe for use on patients with mechanical heart valves. A clinical trial in Europe was recently stopped because users were more likely to experience strokes, heart attacks, and blood clots forming on the mechanical heart valves than were users of the anticoagulant warfarin. There was also more bleeding after valve surgery in Pradaxa users than in warfarin users. Pradaxa's competitors include: Eliquis, from Bristol-Myers Squibb (BMY) and Pfizer (PFE), Xarelto from Johnson & Johnson (JNJ) and Coumadin, an older drug that's also from BMY.

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Comments (4)
  • sabalos
    , contributor
    Comments (107) | Send Message
    What about Pacemakers?
    19 Dec 2012, 07:31 PM Reply Like
  • Old Trader
    , contributor
    Comments (5732) | Send Message
    Just a guess on my part, but there's a notable difference between a pacemaker, and a mechanical valve. Blood actually passes through the valve, so it makes sense that the possibility of added chemicals in the blood may cause some sort of negative reaction, whereas a pacemaker uses electrical current to "stimulate" the heart to maintain the proper rhythm....blood doesn't actually pass through it.
    19 Dec 2012, 07:39 PM Reply Like
  • sabalos
    , contributor
    Comments (107) | Send Message
    19 Dec 2012, 09:07 PM Reply Like
  • biochemist
    , contributor
    Comments (715) | Send Message
    Hey SA, "Coumadin" (trade name) IS "warfarin" (generic name). Somebody should be fact-checking these press releases.
    21 Dec 2012, 05:21 PM Reply Like
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