Endo International plcNASDAQ
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  • Thu, Nov. 17, 9:28 AM
    • Endo International (NASDAQ:ENDP) is up 6% premarket on increased volume in response to its announcement of positive results from a Phase 2b clinical trial assessing collagenase clostridium histolyticum (CCH) for the treatment of edematous fibrosclerotic panniculopathy (EFP), commonly known as cellulite.
    • The study enrolled 375 adult women with moderate or severe cellulite. Results showed a highly statistically significant improvement in the appearance of cellulite.
    • CCH is marketed in the U.S. as XIAFLEX for the treatment of Dupuytren's contracture and Peyronie's disease.
    | Thu, Nov. 17, 9:28 AM | 2 Comments
  • Thu, Nov. 17, 9:20 AM
    | Thu, Nov. 17, 9:20 AM | 9 Comments
  • Thu, Nov. 10, 9:17 AM
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  • Tue, Nov. 8, 9:17 AM
    | Tue, Nov. 8, 9:17 AM
  • Tue, Nov. 8, 6:48 AM
    • Endo (ENDP) Q3 results: Revenues: $884.3M (+18.6%); Operating Loss: ($36M) (+95.4%); Net Loss: ($191.5M) (+76.2%); Loss Per Share: ($0.86) (+77.6%); Non-GAAP EPS: $1.01 (-1.0%); Quick Assets: $561.6M (+106.2%); CF Ops: $443.4M (-349.9%).
    • 2016 Guidance: GAAP EPS: $0.98 - 1.28; Non-GAAP EPS: $4.50 - 4.80.
    | Tue, Nov. 8, 6:48 AM | 9 Comments
  • Tue, Nov. 8, 6:31 AM
    • Endo (NASDAQ:ENDP): Q3 EPS of $1.01 beats by $0.20.
    • Revenue of $884.34M (+18.6% Y/Y) beats by $22.04M.
    • Shares -0.13% PM.
    • Press Release
    | Tue, Nov. 8, 6:31 AM
  • Mon, Nov. 7, 5:30 PM
  • Fri, Nov. 4, 3:38 PM
    • The major averages are flat, but the XLV is higher by 1%, and the IBB by 2.15% as pharmaceutical names rebound from yesterday's plunge.
    • Sending the stocks down was word of charges about to come from the government following a two-year antitrust probe, but public outrage goes with the territory, says Zacks' Tracey Ryniec, noting the prices - with some at just four or five times earnings - are getting seriously cheap.
    • Among those moving today: Endo International (ENDP +1.8%), Perrigo (PRGO +3%), Mylan (MYL +2.6%), Allergan (AGN +3.4%), Cara (CARA +23.8%), PTC (PTCT +20%), Novavax (NVAX +18.9%), Flex (FLKS +14.5%), Cerus (CERS +14.9%), LifePoint (LPNT +2.9%), and Halyard Health (HYH +3.2%).
    | Fri, Nov. 4, 3:38 PM | 19 Comments
  • Fri, Nov. 4, 6:00 AM
    • In a note this morning, Credit Suisse addresses what exactly was new in yesterday's Bloomberg article about potential price-fixing charges against generic drugmakers:
    • "The investigation itself wasn’t news, most generics manufacturers had disclosed receipt of subpoenas, but we sense most investors felt the investigation wouldn’t come to anything. This afternoon’s news that charges could be brought by year-end obviously brought immediacy to the issue and at a time when investor confidence is fragile. Investors have been concerned the consolidating purchasing consortiums of drug chains and wholesalers (top-4 buying groups now represent 84% of purchasing in the U.S.) have used their buying power at the manufacturers expense. Regardless of the outcome of the investigation, the ongoing government scrutiny could hinder generic manufacturers' counter moves especially in terms of price exploration for individual products. That said, and appreciating the matter can’t be taken lightly, we think it would be premature to conclude this signals a dramatic change in the generic drug industry’s landscape over the long-term.  There continue to be regulatory and manufacturing capacity issues which work in the generic manufacturers' favor."
    • Among the hardest hit were LCI (-26.6%), ENDP (-19.5%), IPXL -19.5%, AKRX -18%. Healthcare ETF XLV was down just 1%. Large-cap generic manufacturers such as MYL and TEVA were down 6-10%.
    | Fri, Nov. 4, 6:00 AM | 29 Comments
  • Thu, Nov. 3, 2:57 PM
    | Thu, Nov. 3, 2:57 PM | 225 Comments
  • Thu, Oct. 20, 5:04 PM
    • Endo International plc (NASDAQ:ENDP) EVP and Chief Financial Officer Suketu Upadhyay notifies the company that he will resign effective November 22 to assume a senior finance position at another firm. EVP of Global Finance Operations Blaise Coleman will serve as interim CFO until a permanent successor is hired.
    | Thu, Oct. 20, 5:04 PM
  • Fri, Sep. 30, 9:20 AM
    • Endo Pharmaceuticals (ENDP) announces that new data will be presented evaluating the safety and efficacy of XIAFLEX (collagenase clostridium histolyticum) (CCH) injection under investigation for the treatment of palmar Dupuytren's disease nodules. The presentation will be made tomorrow, October 1, at the annual meeting of the American Society for Surgery of the Hand in Austin, TX.
    • In a Phase 2, randomized, double-blind, placebo-controlled, dose-ranging study in 75 adults, participants in the higher dose groups treated with a single injection of XIAFLEX showed a statistically significant decrease in size and hardness of Dupuytren's disease nodules, a pre-cursor condition to Dupuytren's contracture. The safety profile of those treated with CCH was generally well tolerated. Adverse events included extremity pain, axillary pain, injection site-related adverse events and pruritus. No patients were discontinued from the study because of an adverse event.
    • The majority of study participants receiving higher doses of CCH were satisfied with their treatment and outcomes. Similarly, the investigators' global assessment showed an improvement in study participants versus placebo.
    • Dupuytren's disease is a common fibroproliferative disease of the palmar fascia. It is characterized by thickening and shortening of fibrous cords within the hand that impact the finger joints (particularly metacarpophalangeal and proximal interphalangeal joints of the ring and small fingers) and while it can start with the appearance of palmar nodules, often leads to flexion contraction and reduced function, also known as Dupuytren's contracture. 
    • XIAFLEX is a biologic approved in the U.S., EU, Canada and Australia for the treatment of adult Dupuytren's contracture patients with a palpable cord and approved in the U.S. for the treatment of adult men with Peyronie's disease with a palpable plaque and penile curvature deformity of at least 30 degrees at the start of therapy.
    • Shares up 1% premarket on average volume.
    | Fri, Sep. 30, 9:20 AM | 5 Comments
  • Fri, Sep. 23, 12:45 PM
    | Fri, Sep. 23, 12:45 PM | 2 Comments
  • Fri, Sep. 23, 11:01 AM
    | Fri, Sep. 23, 11:01 AM | 5 Comments
  • Fri, Sep. 23, 9:14 AM
    | Fri, Sep. 23, 9:14 AM | 1 Comment
  • Fri, Sep. 23, 8:35 AM
    • Endo International plc (ENDPannounces that its Board of Directors has named Paul V. Campanelli President and Chief Executive Officer, effective immediately. Mr. Campanelli currently serves as President of Endo's Generic and OTC drugs business, Par Pharmaceutical, which accounts for ~60% of Endo's total revenues through the first half of 2016.
    • Campanelli joined Endo in 2015 following Endo's acquisition of Par, where he had served as CEO since 2012.
    • Shares up 7% premarket
    | Fri, Sep. 23, 8:35 AM | 1 Comment