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Fri, Sep. 19, 9:18 AM| Comment!
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Wed, Jul. 2, 8:22 AM
- Advaxis (ADXS) announces that development partner Aratana Therapeutics (PETX) has submitted a product license application with the USDA for ADXS-cHER2, its proprietary HER2/neu-directed cancer immunotherapy for the treatment of canine osteosarcoma and other HER2-overexpressing cancers. The USDA typically responds to filings within 12 to 18 months.
- ADXS-cHER2 is an investigational Lm-LLO cancer immunotherapy that targets the HER2 receptor, which is overexpressed in certain solid tumor cancers, including canine and human bone and breast cancer. Advaxis is currently advancing a clinical program for ADXS-cHER2 in osteosarcoma in humans which has been granted Orphan Drug status by the FDA.
Wed, Jun. 18, 5:36 PM
Fri, Jun. 13, 8:18 AM
- Aratana Therapeutics (PETX) licenses Vet-Stem's allogenic stem cells in an exclusive agreement for the U.S. If approved by the FDA, it will be the first "off the shelf" regenerative cell therapy for the treatment of osteoarthritis in dogs.
- Under the terms of the agreement, Aratana has an exclusive license to develop and commercialize Vet-Stem's technology in the U.S. for the treatment of pain and inflammation in canine osteoarthritis. It will pay Vet-Stem a $500K license fee at signing and up to $4.5M in success-based milestone payments. Aratana has exclusive rights to negotiate an expansion of the territory to include the European Union during 2014.
- Aratana intends to conduct clinical trials to assess the therapy's safety and efficacy. A dose confirmation study will commence this month. The company does not expect regulatory clearance before 2016.
Tue, May. 13, 4:24 PM| Comment!
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Nov. 20, 2013, 5:05 PM
- Aratana Therapeutics (PETX) says dogs that received AT-001 in a dose-ranging study of osteoarthritis "demonstrated improvements in pain assessment scores that were statistically significant compared to placebo."
- The company plans to move the drug into a pivotal study next year and expects approval in 2016. (PR)
Nov. 13, 2013, 5:40 PM
Oct. 14, 2013, 6:30 AM
- The acquisition is expected to significantly accelerate Aratana's (PETX) pathway toward becoming a commercial-stage pet therapeutics company.
- Aratana will pay to Vet $30M in cash, issue 625K shares of common stock, and issue a promissory note for $3M with a maturity date of December 31, 2014. Aratana will also pay up to $5M cash upon the achievement of certain regulatory and manufacturing milestones for the B-cell lymphoma product.
- Aratana also said that it has entered into a share purchase agreement providing for $19.75M of common shares - 1,234,375 shares at $16.00 per share.
Sep. 12, 2013, 12:45 PM
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