XLRN
Acceleron Pharma Inc.NASDAQ
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  • Mon, Dec. 5, 8:13 AM
    • Results from an investigator-sponsored Phase 2 clinical trial evaluating Acceleron Pharma's (NASDAQ:XLRN) sotatercept in patients with myelofibrosis showed a 36% response rate. The data were presented at the 58th American Society of Hematology (ASH) annual meeting in San Diego.
    • 19 subjects were enrolled in the study. 14 who received at least five doses of sotatercept were evaluable for response. Five of the 14 (36%) achieved an anemia response, defined as a composite of independence from red blood cell transfusion and hemoglobin response from baseline.
    • 68% (n=13/19) have discontinued, including five non-responders, two who progressed, two proceeded to stem cell transplantation, one transformed to acute myeloid leukemia and one withdrew consent.
    • Adverse events possibly related to treatment were grade 3 (severe) hypertension leading to discontinuation, grade 1 myalgia, bone pain, pain in extremity and injection site reaction.
    • Sotatercept is a fusion protein that acts as a ligand trap for proteins involved in fibrosis and late-stage erythropoiesis (red blood cell production). It is being co-developed with Celgene (NASDAQ:CELG) for the treatment of chronic kidney disease.
    • Management will host a conference cal this morning at 9:00 am ET to discuss the data.
    | Mon, Dec. 5, 8:13 AM
  • Thu, Nov. 3, 4:25 PM
    • Acceleron Pharma (NASDAQ:XLRN): Q3 EPS of -$0.55 misses by $0.02.
    • Revenue of $3.01M (-27.6% Y/Y) misses by $1.07M.
    • Press Release
    | Thu, Nov. 3, 4:25 PM
  • Wed, Nov. 2, 5:35 PM
  • Tue, Sep. 27, 4:26 PM
    • Acceleron Pharma (NASDAQ:XLRN) appoints Habib Dable as President & CEO effective December 1. He succeeds the retiring John Knopf. Mr. Dable joins the firm from Bayer AG where he was President of Pharmaceuticals.
    | Tue, Sep. 27, 4:26 PM
  • Fri, Aug. 26, 7:15 AM
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    • Jazz Pharmaceuticals (NASDAQ:JAZZ) initiated with Neutral rating by Janney Montgomery Scott.
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    • Patheon NV (Pending:PTHN) initiated with Outperform rating by William Blair.
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    • Rockwell Medical (NASDAQ:RMTI) initiated with Buy rating and $12 (72% upside) price target by BTIG Research.
    • Agios Pharmaceuticals (NASDAQ:AGIO) initiated with Neutral rating by BTIG Research.
    • TRACON Pharmaceuticals (NASDAQ:TCON) initiated with Buy rating and $15 (137% upside) price target by BTIG Research.
    • Ophthotech (NASDAQ:OPHT) initiated with Buy rating and $92 (76% upside) price target by BTIG Research.
    • Merrimack Pharmaceuticals (NASDAQ:MACK) initiated with Neutral rating by BTIG Research.
    • Acceleron Pharma (NASDAQ:XLRN) initiated with Buy rating and $46 (55% upside) price target by BTIG Research.
    | Fri, Aug. 26, 7:15 AM | 15 Comments
  • Thu, Aug. 4, 7:23 AM
    • Acceleron Pharma (NASDAQ:XLRN): Q2 EPS of -$0.59 misses by $0.09.
    • Revenue of $3.2M (-44.1% Y/Y) misses by $0.57M.
    • Press Release
    | Thu, Aug. 4, 7:23 AM
  • Wed, Aug. 3, 5:30 PM
  • Fri, Jun. 10, 7:50 AM
    • Acceleron Pharma (NASDAQ:XLRN) and development partner Celgene (NASDAQ:CELG) announce preliminary results from a Phase 2 clinical trial evaluating Fast Track-tagged luspatercept in patients with beta thalassemia, an inherited blood disorder that reduces the production of hemoglobin. The results were presented at the 21st Congress of the European Hematology Association in Copenhagen.
    • 80% (n=24/30) of patients treated with luspatercept achieved at least a 20% reduction in transfusion burden while 36% (n=8/22) achieved an increase in hemoglobin of at least 1.5 g/dL (normal range for men: 13.5 - 17.5 g/dL; women: 12.0 - 15.5 g/dL). In the long-term extension study the proportions improved to 96% (n=23/24) and 56% (n=15/27), respectively.
    • Luspatercept is a protein therapeutic called a ligand trap. It promotes red blood cell formation by inhibiting members of the transforming growth factor beta superfamily, proteins that induce programmed cell death (apoptosis). A Phase 3 study in beta thalassemia, BELIEVE, is ongoing.
    • Acceleron will host a conference call this morning at 8:00 am ET to discuss the data.
    | Fri, Jun. 10, 7:50 AM | 4 Comments
  • Thu, May 5, 7:14 AM
    • Acceleron Pharma (NASDAQ:XLRN): Q1 EPS of $0.13 beats by $0.39.
    • Revenue of $18.2M (+311.8% Y/Y) beats by $8.71M.
    | Thu, May 5, 7:14 AM | 1 Comment
  • Fri, Mar. 4, 9:44 AM
    • Walgreens Boots Alliance (NASDAQ:WBA) upgraded to Buy from Neutral by Mizuho Securities. Price target raised to $75 (6% downside risk).
    • Acceleron Pharma (NASDAQ:XLRN) upgraded to Buy from Neutral by Janney Capital. Price target lowered to $39 (39% upside) from $45.
    • Keryx Biopharmaceuticals (NASDAQ:KERX) upgraded to Outperform from Market Perform by FBR Capital. Price target is $10 (145% upside).
    • Zimmer Biomet Holdings (NYSE:ZBH) downgraded to Hold from Buy by Argus Research.
    • Valeant Pharmaceuticals (NYSE:VRX) downgraded to Hold from Buy by Canaccord Genuity. Price target lowered to $75 (15% upside) from $125. Downgraded to Sector Perform from Outperform by RBC Capital. Price target lowered to $85 (31% upside) from $194.
    • TeamHealth Holdings (NYSE:TMH) downgraded to Hold from Buy by Jefferies. Price target lowered to $65 (44% upside).
    • McKesson (NYSE:MCK) downgraded to Neutral from Buy by Mizuho Securities. Price target lowered to $164 (1% upside).
    • Diplomat Pharmacy (NYSE:DPLO) downgraded to Neutral from Overweight by JP Morgan. Price target lowered to $30 (9% upside) from $52.
    • Rockwell Medical (NASDAQ:RMTI) downgraded to Hold from Buy by Stifel. $19 price target removed. Also downgraded to Hold from Buy by Craig-Hallum.
    • China Biologic Products (NASDAQ:CBPO) downgraded to Neutral from Outperform by Credit Suisse. Price target raised to HK$129.
    • Orexigen Therapeutics (NASDAQ:OREX) downgraded to Sector Perform from Outperform by RBC Capital. Price target lowered to $1 (43% upside) from $5.
    • Vivus (NASDAQ:VVUS) downgraded to Sector Perform from Outperform by RBC Capital. Price target lowered to $1 (6% downside risk) from $4.
    | Fri, Mar. 4, 9:44 AM | 24 Comments
  • Thu, Feb. 25, 7:20 AM
    • Acceleron Pharma (NASDAQ:XLRN): Q4 EPS of -$0.81 misses by $0.72.
    • Revenue of $3.8M (+1.6% Y/Y) misses by $11.9M.
    | Thu, Feb. 25, 7:20 AM
  • Fri, Jan. 22, 8:23 AM
    • Credit Suisse analysts have been very busy lately with a long list of initiations: Acceleron Pharma (NASDAQ:XLRN) Outperform with $50 (47% upside) price target; BioMarin Pharmaceutical (NASDAQ:BMRN) Outperform with $110 (36% upside) price target; Amgen (NASDAQ:AMGN) Outperform with $205 (34% upside) price target.
    • Celgene (NASDAQ:CELG) Outperform with $149 (41% upside) price target; Coherus Biosciences (NASDAQ:CHRS) Outperform with $25 (79% upside) price target; Gilead Sciences (NASDAQ:GILD) Outperform with $125 (40% upside) price target.
    • Regeneron Pharmaceuticals (NASDAQ:REGN) Neutral with $552 (19% upside) price target; Vertex Pharmaceuticals (NASDAQ:VRTX) Outperform with $151 (59% upside) price target; Alnylam Pharmaceuticals (NASDAQ:ALNY) Outperform with $154 (117% upside) price target.
    • Alexion Pharmaceuticals (NASDAQ:ALXN) Neutral rating with $201 (29% upside) price target; Biogen (NASDAQ:BIIB) Neutral with $322 (23% upside) price target; XenoPort (NASDAQ:XNPT) Underperform with $4 (16% downside risk) price target.
    • PTC Therapeutics (NASDAQ:PTCT) Outperform with $36 (33% upside) price target; Mesoblast Limited (NASDAQ:MESO) Outperform with $10 (92% upside) price target and Incyte (NASDAQ:INCY) Outperform with $110 (49% upside) price target.
    | Fri, Jan. 22, 8:23 AM | 3 Comments
  • Tue, Jan. 5, 7:43 PM
    • Acceleron Pharma (NASDAQ:XLRN) has priced its public offering of 3.75M shares of common stock, at $40/share.
    • Shares tumbled 10.3% today in the wake of last night's announcement of the offering, to close at $40.22.
    • As expected, gross proceeds will come to $150M; underwriters have a 30-day greenshoe option. Net proceeds are expected at about $140.4M, which will be put toward clinical trials and related activities.
    • Previously: Acceleron initiates $150M equity offering (Jan. 04 2016)
    | Tue, Jan. 5, 7:43 PM
  • Mon, Jan. 4, 5:11 PM
    • Acceleron Pharma (NASDAQ:XLRN) commences a $150M public offering of common stock. Volume, price and terms have yet to be announced.
    • Net proceeds will fund the clinical development of ADE-083 and other candidates, R&D, capex, working capital and general corporate purposes.
    | Mon, Jan. 4, 5:11 PM | 1 Comment
  • Dec. 7, 2015, 7:18 AM
    • Acceleron Pharma (NASDAQ:XLRN) announces that the FDA has designated luspatercept for Fast Track review for the treatment anemia in patients with lower-risk myelodysplastic syndromes.
    • Fast Track status provides for more frequent interactions with the FDA review team and a rolling review of the New Drug Application (NDA).
    • Luspatercept, being co-developed with Celgene (NASDAQ:CELG) is a protein therapeutic called a ligand trap. It promotes red blood cell formation by inhibiting members of the transforming growth factor beta superfamily, proteins that induce programmed cell death (apoptosis).
    • The FDA designated luspatercept for Fast Track review for the treatment of beta thalassemia in May.
    • Previously: Luspatercept Fast Track'd for beta thalassemia (May 18)
    • Previously: Acceleron's luspatercept shows encouraging results in Phase 2 trials (June 15)
    | Dec. 7, 2015, 7:18 AM | 2 Comments
  • Nov. 4, 2015, 7:02 AM
    • Acceleron Pharma (NASDAQ:XLRN): Q3 EPS of -$0.36 beats by $0.10.
    • Revenue of $4.16M (+18.5% Y/Y) misses by $0.22M.
    | Nov. 4, 2015, 7:02 AM