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Arrowhead Research Corporation (ARWR)

- NASDAQ
  • Thu, Mar. 5, 9:15 AM
    | 2 Comments
  • Thu, Mar. 5, 8:06 AM
    • Arrowhead Research (NASDAQ:ARWR) acquires Novartis' (NYSE:NVS) RNA interference (RNAi) R&D portfolio and associated assets, including certain patents and patent applications, an exclusive license to other patents and patent applications owned or controlled by Novartis, the assignment of a third party license and three preclinical product candidates.
    • Specific assets include multiple patent families covering RNAi-trigger design rules and modifications that fall outside of competitors' patents which provides Arrowhead freedom to operate for any target or indication, the assignment of Novartis' license from Alnylam (NASDAQ:ALNY) that gives Arrowhead access to Alnylam IP, excluding delivery, covering 30 gene targets and three product candidates with varying amounts of preclinical data.
    • Under the terms of the agreement, Arrowhead will pay $10M in cash (includes $7M paid previously) and $25M in ARWR stock within 30 days. Novartis is eligible to receive milestones and single-digit royalties on net sales.
    • Arrowhead will host a conference call this morning at 8:30 am to discuss the deal.
    | 1 Comment
  • Mon, Feb. 9, 4:03 PM
    • Arrowhead Research Corporation (NASDAQ:ARWR): FQ1 EPS of -$0.41 misses by $0.07.
    • Revenue of $0.17M (+325.0% Y/Y)
    • Press Release
    | 7 Comments
  • Mon, Feb. 2, 4:15 PM
    • Arrowhead Research (NASDAQ:ARWR) will report fiscal Q1 results on February 9 after the close. The conference call will begin at 4:30 pm ET.
    | 6 Comments
  • Thu, Jan. 22, 9:15 AM
    | 1 Comment
  • Mon, Jan. 12, 1:27 PM
    • Arrowhead Research (ARWR -25.5%) plummets on more than double normal volume after the company disclosed that the FDA has placed a partial clinical hold on the multiple-dose study evaluating ARC-520 in patients with chronic hepatitis B infection. The company will be able to proceed with the 1 mg/kg dose but not the planned 2 mg/kg and 4 mg/kg parallel doses.
    • The FDA also requested additional information including a final report from the single-dose Phase 2a study in patients who received 1-4 mg/kg ARC-520 and a final report from an ongoing multiple-dose non-clinical study. The agency committed to sending a letter to the firm detailing the issues within 30 days.
    • The company intends to start additional Phase 2b trials in Asia and Europe in the coming weeks.
    | 3 Comments
  • Mon, Jan. 12, 12:46 PM
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  • Mon, Jan. 12, 9:14 AM
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  • Fri, Jan. 2, 8:33 AM
    • Arrowhead Research (NASDAQ:ARWR) is up 5% premarket on higher-than-normal volume. Rumors that Gilead Sciences may be eyeing the company stoked an up move on Tuesday.
    • Previously: Arrowhead up on rumor of Gilead interest (Dec. 30, 2014)
    | 1 Comment
  • Dec. 31, 2014, 9:15 AM
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  • Dec. 30, 2014, 12:48 PM
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  • Dec. 30, 2014, 12:26 PM
    • Small cap Arrowhead Research (ARWR +17.5%) is up on 50% higher volume on rumors that Gilead Sciences (GILD -0.9%) may be eyeing the company for its RNA interference-based drugs.
    • Arrowhead has yet to recover from the plunge in October after it reported Phase 2a results for its hepatitis B candidate, ARC-520, that fell short of investors' expectations.
    • Gilead has three drugs in development for the treatment of chronic HBV infection: tenofovir alafanamide, a nucleotide reverse transcriptase inhibitor, GS-4774, a Tarmogen T cell immunity stimulator and GS-9620, a TLR-7 agonist in addition to the commercially available Viread (tenofovir disoproxil fumarate) and Hepsera (adefovir dipivoxil).
    • Previously: Arrowhead explains the ARC-520 data (Oct. 9)
    | 31 Comments
  • Nov. 26, 2014, 7:08 AM
    • Arrwohead Research Corp. (ARWR -5.3%) FY2014 results: Revenues: $175K (-39.7%); R&D Expense: $23.1M (+165.5%); SG&A: $5.9M (+68.6%); Operating Loss: ($53.3M) (-116.7%); Net Loss: ($58.7M) (-85.2%); Loss Per Share: ($1.25) (+3.8%); Quick Assets: $132.5M (+593.7%).
    • No guidance given.
    | Comment!
  • Nov. 25, 2014, 4:26 PM
    • Arrowhead Research Corporation (NASDAQ:ARWR): FY14 EPS of -$1.25 vs. -$1.30 in FY13.
    • Revenue of $175K (-39.7% Y/Y).
    • Press Release
    | Comment!
  • Nov. 18, 2014, 4:14 PM
    • Arrowhead Research (NASDAQ:ARWR) will report fiscal Q4 and full-year results on Tuesday, November 25 after the close. The conference call will begin at 1:30 pm PT/4:30 pm ET.
    • Consensus view is a loss of ($0.24) per share on revenues of $40K.
    | Comment!
  • Oct. 9, 2014, 9:18 AM
    • In an open letter to shareholders, Arrowhead Research (NASDAQ:ARWR) CEO Christopher Anzalone, Ph.D., says the market's reaction to the Phase 2a study of ARC-520 surprised the firm considering the consistent nature of the company's communications on the matter. He believes investors expected something different (obviously) or misunderstood the data.
    • Their goal of a l log (90% knockdown) reduction in HBsAg after a single administration is arbitrary since the degree of knockdown necessary to de-repress the immune system and potentially enable a functional cure is unknown. They chose 1 log based on the scientific literature on the small number of patients on Interferon therapy who achieved a functional cure on the basis of a 1/2 log (70% knockdown) reduction in HBsAg after 12 weeks and a 1 log reduction after 24 weeks. Dr. Anzalone refers to the 1 log goal as "intellectually honest."
    • The Phase 2a trial is a dose-finding study. Management disclosed that the first two dose levels (1 mg/kg, 2 mg/kg) would not meet their knockdown goals in the August 12 earnings call. They are prepared to go up to 4 mg/kg since there is little risk of toxicity based on their unblinded Phase 1 safety data. They have just completed dosing eight patients in the 3 mg/kg cohort and will escalate to 4 mg/kg as the data come in.
    • In an animal study on a hepatitis B-infected chimpanzee, the HBsAg knockdown was 80 - 85% after it received the 3 mg/kg dose.
    • The market appears receptive to Dr. Anzalone's explanation. Shares are up 9% premarket on healthy volume.
    | 8 Comments
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Company Description
Arrowhead Research Corp is engaged in developing novel drugs to treat intractable diseases by silencing the genes. The Company's drug candidate ARC-520 is designed to treat chronic hepatitis B infection.
Sector: Healthcare
Industry: Biotechnology
Country: United States