Wed, Jun. 10, 5:38 PM
Tue, Mar. 24, 5:35 PM
Wed, Jan. 7, 8:50 AM
- Thinly-traded nano cap Galectin Therapeutics (NASDAQ:GALT) is up 49% premarket on robust volume in response to its report of results from a 30-patient Phase 1 study of GR-MD-02 in patients with nonalcoholic steatohepatitis (NASH).
- The principal objective of the trial was to assess the safety, tolerability and pharmacokinetics of GR-MD-02 but investigators also noted a potential therapeutic effect on fibrosis as measured by a serum biomarker (FibroTest) and liver stiffness (FibroScan). Patients in cohort 3 who received 8 mg/kg GR-MD-02 showed a statistically significant reduction in FibroTest score versus placebo in one of the cohorts.
- Fibrotest is a composite score of six blood tests that correlate to the extent of liver fibrosis.
- NASH represents the next big potential payoff for drug firms after HCV.
- Previously: Galectin NASH treatment meets primary endpoint in Phase 1 (Nov. 10, 2014)
- NASH-associated tickers: (NASDAQ:GILD) (NASDAQ:SHPG) (NASDAQ:LJPC) (NASDAQ:CNAT) (NASDAQ:ICPT) (NASDAQ:RPTP)
Aug. 8, 2014, 3:49 PM
- First the good news:
- Tekmira (TKMR +38.1%) on a massive 25M share turnover; Raptor Pharmaceuticals (RPTP +28.2%) on a 4x surge in volume; Clovis Oncology (CLVS +11.6%) on 50% higher volume; RadNet (RDNT +20.4%) on 2x higher volume and Relypsa (RLYP +15%) on 2x higher volume.
- Now the bad news:
- TearLab (TEAR -21.2%) on 4x higher volume; Masimo (MASI -10.6%) on 3x higher volume; Volcano (VOLC -19.9%) on a 12x surge in volume and Hanger (HGR -24.9%) on a 16x surge in volume.
Aug. 8, 2014, 12:47 PM
Jun. 20, 2014, 5:36 PM
Jun. 17, 2014, 5:35 PM
Mar. 14, 2014, 12:48 PM
Mar. 13, 2014, 5:42 PM
Feb. 20, 2014, 12:47 PM
Feb. 20, 2014, 11:28 AM
- "Procysbi should become an important alternative for treating patients with nephropathic cystinosis," writes analyst William Tanner reiterating his Outperform and $17 price target. "The pace of market uptake has somewhat debunked the notion that the cost of therapy would adversely position the drug vs. Cystagon."
- Today's "encouraging" data on RP103 for Huntington's Disease, may also include evidence the drug could be "effective for treating a broad range of conditions characterized by mitochondrial disorders and intracellular cystine accumulation."
- RPTP +13.4%
Feb. 20, 2014, 9:11 AM
Jan. 10, 2014, 9:13 AM
Jan. 10, 2014, 8:54 AM
- Add Raptor Pharmaceuticals (RPTP) to the list of stocks benefiting from the rally in liver disease plays sparked Thursday by ICPT.
- The company — which is developing RP103 for NAFLD — saw its shares rise 6% yesterday, and early trading suggests today will be another positive session.
- RPTP +7.5% premarket
- See also: GALT, CNAT piggyback on ICPT NASH results
Sep. 27, 2013, 5:37 PM
Sep. 25, 2013, 9:37 AM
- Raptor Pharmaceuticals (RPTP) falls in early trading on the heels of an Oppenheimer downgrade.
- "We believe that the market is already pricing in Procysbi adoption by 80%+ patients in the US and EU at current valuation," analyst Boris Peaker says, removing his $11 price target.
- Oppenheimer also says success in Huntington's (RP103) is critical for RPTP — "we view [this] as very risky," Peaker notes.
- Another concern: Procysbi pricing in Europe as "reimbursement may be more challenging" than in the U.S. See: Procysbi gets EU marketing authorization.
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