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Teva Pharmaceutical Industries Limited (TEVA)

  • Thu, Oct. 1, 8:42 AM
    • Teva Pharmaceutical Industries (NYSE:TEVA) acquires Mexico City-based Representaciones e Investigaciones Medicas, S.A. de C.V. (Rimsa) for $2.3B. The transaction establishes Teva as the leading pharma firm in Mexico and positions it for long-term growth in Latin America.
    • Rimsa's revenues for 2014 were $227M with an annual top-line growth rate of over 10%.
    • The deal, funded with cash on hand and lines of credit, should close in Q1. It is expected to be accretive to Teva's non-GAAP earnings starting Q1 2017.
    • TEVA is up 2% premarket on average volume.
    | Thu, Oct. 1, 8:42 AM | Comment!
  • Wed, Sep. 30, 12:49 PM
    • Bruised and battered biotech investors get some welcome buying today as bargain hunters open their wallets. The iShares Nasdaq Biotech Index Fund (IBB +2%) is up nicely, albeit on average volume.
    • Key tickers: (AMGN +1.6%)(BIIB +2.5%)(GILD +1%)(CELG +0.7%)(DEPO +12.4%)(HZNP +8.6%)(NVO +0.7%)(AGN +4.9%)(VRX +6.4%)(REGN +0.9%)(TEVA +2%)(SHPG +2.6%)
    | Wed, Sep. 30, 12:49 PM | 26 Comments
  • Mon, Sep. 28, 4:53 PM
    • Allergan (NYSE:AGN) says it will begin reporting its Global Generic business as discontinued operations in Q3, ahead of the closing of its deal with (NYSE:TEVA), which is expected to close in Q1 2016.
    • Its forecast for H2 for continuing operations (U.S. Brands, U.S. Medical, International Brands and Anda distribution) calls for revenues greater than $8B, non-GAAP EBIT between $3.8B - 4.0B and non-GAAP EPS between $6.25 and 6.65.
    • After the TEVA deal closes, the company expects 10% branded revenue per year, non-GAAP gross margins of 77 - 79%; non-GAAP SG&A as a percentage of revenue of 21 - 24% and a non-GAAP tax rate of ~15%.
    | Mon, Sep. 28, 4:53 PM | 3 Comments
  • Mon, Sep. 28, 7:53 AM
    • The Japanese Ministry of Health, Labour and Welfare approves Teva Pharmaceutical Industries' (NYSE:TEVA) COPAXONE (glatiramer acetate injection) 20 mg for the prevention of relapse of multiple sclerosis (MS). The product will be commercialized there by Takeda Pharmaceutical (OTCPK:TKPHF) (OTCPK:TKPYY).
    • COPAXONE is Teva's biggest seller by far, generating $4.2B in sales over the past four quarters.
    | Mon, Sep. 28, 7:53 AM | 1 Comment
  • Fri, Sep. 25, 9:38 AM
    • Teva Pharmaceutical Industries (NYSE:TEVA) acquires Cambridge, MA-based Gecko Health Innovations for an undisclosed sum. Gecko creates smart solutions that help patients with chronic diseases to better manager their condition. With an initial focus on COPD and asthma, it has designed and built hardware and software solutions to collect and present important data in a high-value-added way using behavioral tools to promote better disease management. It launched CareTRx this year, which is a cloud-based solution designed to simplify chronic respiratory disease management via connecting patients and caregivers through remote monitoring and real-time adherence tools.
    • The acquisition will allow Teva to explore innovative ways to apply the CareTRx technology to its pipeline and portfolio of respiratory products with the aim of improving clinical outcomes for patients.
    | Fri, Sep. 25, 9:38 AM | 1 Comment
  • Fri, Sep. 18, 6:13 PM
    • Mexico City-based generic drugmaker Representaciones e Investigaciones Medicas -- Rimsa -- is drawing interest from big pharma companies, particularly including Pfizer (PFE -1.9%), Sanofi (SNY -3%) and Abbott Laboratories (ABT -2.1%), Bloomberg reports.
    • Rimsa could draw about $1B in a purchase by any of a list of suitors, which also could include Teva (TEVA -1.6%) and Takeda (OTCPK:TKPYY -1.9%).
    • Healthcare spending rates in Mexico are expected to rise to be more in line with other emerging markets like Brazil and Chile. Spending is relatively low and the market is fragmented.
    • Goldman Sachs is managing the sale.
    | Fri, Sep. 18, 6:13 PM | Comment!
  • Thu, Sep. 10, 11:17 AM
    • The FDA accepts for review the supplemental New Drug Application (sNDA) from Teva Pharmaceutical Industries (TEVA -0.3%) seeking approval for the use of ProAir RespiClick (albuterol sulfate) Inhalation Powder for the treatment of bronchospasm in pediatric patients aged four to 11 years.
    • ProAir's current label, approved in March, applies to patients at least 12 years old.
    | Thu, Sep. 10, 11:17 AM | Comment!
  • Thu, Sep. 10, 8:46 AM
    • IBM Watson Health announces that Teva Pharmaceutical Industries (NYSE:TEVA) is the first global pharma firm to sign on as a Foundational Life Sciences Partner for the Watson Health Cloud, a cognitive computing platform designed to process vast amounts of healthcare-related Big Data. It is an open development system that can interact in natural language instead of computer code.
    • Teva will work with IBM on developing long-range solutions designed to collect and analyze real world data that will lead to new insights and inform a variety of initiatives such as reducing drug misuse and increasing prescribed medication adherence.
    | Thu, Sep. 10, 8:46 AM | Comment!
  • Tue, Aug. 25, 7:22 PM
    • Eli Lilly (NYSE:LLY) says a U.S. federal court ruled that generic products proposed by a unit of Teva Pharmaceutical (NYSE:TEVA) would infringe a U.S. patent for LLY’s blockbuster cancer drug Alimta.
    • The patent, which covers the administration of Alimta to patients with a vitamin regimen, provides intellectual property protection until May 2022, potentially preserving U.S. market exclusivity for Alimta until then, rather than allowing generic competition in 2017 when a separate patent expires.
    • Teva had challenged a March 2014 ruling that upheld the validity of the vitamin regimen patent.
    | Tue, Aug. 25, 7:22 PM | 3 Comments
  • Wed, Aug. 12, 8:48 AM
    • The FDA accepts for review Teva Pharmaceutical Industries' (NYSE:TEVA) New Drug Application (NDA) seeking approval of Orphan Drug-tagged deutetrabenazine (SD-809) for the treatment of chorea (involuntary movements) associated with Huntington's disease (HD), a rare and fatal inherited neurodegenerative disorder that affects ~20K Americans.
    • Deutetrabenazine is an oral small molecule inhibitor of vesicular monoamine 2 transporter (VMAT2), a membrane protein that transports neurotransmitters such as dopamine and serotonin and is necessary for the vesicular release of the neurotransmitter GABA. Teva acquired ownership of the product candidate via its acquisition of Auspex Pharmaceuticals in May.
    | Wed, Aug. 12, 8:48 AM | Comment!
  • Mon, Aug. 3, 1:43 PM
    • In a recent review of the Kronos Early Estrogen Prevention Study (KEEPS) trial, Dr. JoAnn Manson, investigator and co-author, discusses the therapeutic potential of estrogen for improving cognition and mood.
    • The KEEPS study, published in PLOS Medicine last month, randomly assigned 693 women to one of the following three treatment groups: daily oral conjugated estrogen 0.45 mg with daily cyclical oral micronized progesterone 200 mg, estradiol patch (transdermal) 50 µg with cyclical micronized progesterone for 12 days a month, and placebo. Investigators assessed treatment groups for cognition and mood.
    • After 4 years of treatment and follow-up, the study showed that the oral and transdermal estrogen did not provide statistically significant cognition benefits. In respect to mood, oral conjugated estrogen showed a favorable, but non-statistically significant effect on anxiety and depressive symptoms, whereas the transdermal estradiol had neutral effects.
    • The results suggest that oral conjugated transdermal estrogen could possess a therapeutic benefit for women with mood symptoms. However, more research is required to assess the therapeutic benefit of estrogen for cognition. Dr. Manson stresses that cognitive outcomes are generally more correlative for younger, newly menopausal than for older women.
    • This comes as micro cap Synthetic Biologics (SYN +1.9%) is expected to produce a top-line MRI readout for the Phase 2 study of Trimesta (oral estriol) in female multiple sclerosis patients suffering from cognitive dysfunction. A positive top-line readout would pave the way for continued advancement of the company's cognition program. The investigational drug is also being developed in a separate post-Phase 2 program in combination with Teva's (TEVA +1.1%) blockbuster MS drug Copaxone for the treatment of relapses in MS.
    • There has never been an FDA-approved oral estriol drug for any indication. However, oral estriol has been used to treat post-menopausal symptoms for over 40 years throughout Europe and Asia. The market opportunity for Trimesta is likely significant, with more than 400,000 patients in the U.S. and 2.3 million worldwide. The majority of such patients are young adults aged 20-50. 70% of MS patients are women, and 50% of MS patients are affected by cognitive dysfunction. Annual worldwide sales of existing MS therapies exceed $14 billion, and none of them effectively address cognitive dysfunction.
    • MS-related tickers: (BIIB +0.6%)
    | Mon, Aug. 3, 1:43 PM | 27 Comments
  • Mon, Aug. 3, 9:17 AM
    • Pfizer (NYSE:PFE) acquires the exclusive U.S. commercialization rights to glatiramer acetate, a generic version of Teva's (NYSE:TEVA) blockbuster Copaxone, from Dutch drug firm Synthon. Under the terms of the agreement, Pfizer has exclusive rights in the U.S. for both dosage formulations (20 mg/ml and 40 mg/ml). Synthon will be responsible for the clinical development, manufacture and supply of glatiramer acetate. Financial terms are not disclosed.
    • Synthon filed an ANDA with the FDA in November 2011 for the once-daily 20 mg/ml dose. It filed an ANDA for the 3x-per-week 40 mg/ml dose in early 2014.
    | Mon, Aug. 3, 9:17 AM | 1 Comment
  • Mon, Aug. 3, 8:30 AM
    • To further its emphasis on personalized medicine, Teva Pharmaceutical Industries (TEVA -0.1%) establishes a 51% equity stake in privately-held Cambridge, MA-based Immuneering, a genomic analysis company that employs proprietary algorithms using genetic, genomic and proteomic data to generate biological insights that enhance the clinical and commercial success of medicines.
    • The firms have been working together over the past several years in characterizing non-biological complex drugs in addition to genetic biomarkers and therapy-specific gene expression signatures. Teva has the right of first refusal in projects related to Immuneering's work in central nervous system disorders.
    • The specific amount of Teva's investment is not disclosed.
    | Mon, Aug. 3, 8:30 AM | 1 Comment
  • Fri, Jul. 31, 1:40 PM
    • Teva Pharmaceutical Industries (TEVA -0.3%) receives commitment letters from a group of major banks for loans totaling $33.75B, $27B under a senior unsecured Bridge Loan Credit Facility and $6.75B under an Equity Bridge Loan Credit Facility.
    • Teva will use the funds to pay for its acquisition of Allergan's generic drugs business.
    | Fri, Jul. 31, 1:40 PM | Comment!
  • Thu, Jul. 30, 3:51 PM
    • Teva Pharmaceutical Industries (TEVA -2.6%) resumed at Morgan Stanley with an Overweight rating and price target of $85 (23% upside).
    • Depomed (DEPO -2.9%) downgraded to Sector Perform from Outperform by RBC Capital. Price target raised to $32 (3% upside) from $26.
    • Immunomedics (IMMU -1.2%) downgraded to Hold from Buy by Jefferies. Price target lowered to $2 (4% downside risk) from $6.
    | Thu, Jul. 30, 3:51 PM | 2 Comments
  • Thu, Jul. 30, 7:33 AM
    • Teva Pharmaceutical Industries (NYSE:TEVA) Q2 results ($M): Total Revenues: 4,966 (-1.6%); Generic Medicines: 2,466 (-1.9%); Specialty Medicines: 2,090 (+3.1%); Other: 1,036 (+106.0%).
    • Copaxone sales: 1,054 (+12.2%).
    • Net Income: 539 (-27.7%); EPS: 0.63 (-27.6%); CF Ops: 1,480 (+40.6%).
    • 2015 Guidance: Total Revenues: $19.0B - 19.4B (unch); Gross Margin: 60.0 - 62.5% from 59.5 - 61.5%; Non-GAAP EPS: $5.15 - 5.40 from $5.00 - 5.30.
    • Shares are off a fraction premarket.
    | Thu, Jul. 30, 7:33 AM | Comment!
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Company Description
Teva Pharmaceutical Industries Ltd develops, produces and markets generic, branded & OTC medicines. Some of its products are Copaxone, Azilect & Provigil.
Sector: Healthcare
Country: Israel