Wyeth (WYE)

All Comments on WYE

  • commenter
    User 213166
    Jun 20 09:06 AM
    Elan, Wyeth: Response to Skeptics on Alzheimer's Data [view article]
    great potential Reply
  • commenter
    Texrat
    Jun 19 11:16 PM
    My Website
    Elan, Wyeth: Response to Skeptics on Alzheimer's Data [view article]
    Excellent rebuttal! Reply
  • commenter
    Doug
    Jun 19 09:58 AM
    Alzheimer Drug Fails Trial [view article]
    Personal attacks are the status quo on S.A. Reply
  • commenter
    Eben Tessari
    Jun 19 07:35 AM
    My Website
    Alzheimer Drug Fails Trial [view article]
    I think it's interesting that you all feel personal attacks are somehow a counter point.

    If, when the results are published in July and after the first phase III data is in, I am wrong, I'll be the first to admit it (I doubt you'll be offering me the same consideration and dropping me emails if I'm right).

    Until then, my opinion remains that no program targeting amyloid-beta or the pathway has shown efficacy on the primary (read: approvable) endpoint of ADAS-cog.

    I hope I'm wrong. I hope targeting the amyloid-beta pathway leads to truly disease modifying therapy but believing doesn't make it true.     Reply
  • commenter
    Skeeter1128
    Jun 18 01:38 PM
    Alzheimer Drug Fails Trial [view article]
    This is the only article I can find that even hints at the word "failure" regarding this trial. The results seem very positive to me. The stock is up and indications are a short squeeze is on the way. I wonder, is he short the stock? Reply
  • commenter
    BirdInYourEa
    r
    Jun 18 11:23 AM
    Alzheimer Drug Fails Trial [view article]
    I wish I could edit my previous comment.
    I can't believe I took this guy seriously after reading his article. Take a look at this blog. Put bluntly, this guy is a typical raving internet hack who appears to be trapped in the "blogosphere"...
    I wish you luck in your future pursuits.     Reply
  • commenter
    BirdInYourEa
    r
    Jun 18 11:18 AM
    Alzheimer Drug Fails Trial [view article]
    Do you realize how many people ~40% of the entire Alzheimer's population is? I'm baffled by how a person with your educational background fails to see the importance and benefits of this drug. If you were able to talk to the families of patients who were success stories in phase II (thousands and thousands, as you are well aware, this is not an inflated number), I'm sure you would reconsider your opinion. Reply
  • commenter
    elan goddess
    Jun 18 10:19 AM
    Alzheimer Drug Fails Trial [view article]
    With "quality" analysis such as yours please note that they are still enrolling patients for Phase III.

    Nice pic....you may want to rethink that. You look like the Village Idiot.
    Your picture matches your journalistic skills.     Reply
  • commenter
    A
    neurologist
    Jun 18 10:16 AM
    Alzheimer Drug Fails Trial [view article]
    Eben,
    What medical/scientific qualifications do you possess that allow you to reach such outrageously false and biased statements? Yesterdays news from Elan was a HUGE step forward for Alzheimer treatment. I am convinced that the FDA will now be forced to make the PIII open label for the Non-ApoE4 carriers. In the end, your poorly informed commentary will emerge as the only thing foolish associated with these results.     Reply
  • commenter
    obesejockey
    Jun 18 06:42 AM
    Alzheimer Drug Fails Trial [view article]
    You must be a glass half empty kind of guy, but Alzheimer's is a disease where the disease modifying drug glass is completely empty. The top line results indicate that perhaps half the patients can be helped with statistical significance. The placebo was Aricept. Why not wait for the full study results to be presented at ICAD on July 29 (warts and all) before drawing conclusions about the APOE carrier subgroup? One reason the phase 2 study is under powered is that the study tested several dose levels with the intent to determine the best dose level. The ongoing phase 3 study reflects what was learned in phase 2. Reply
  • commenter
    Oliver
    Jun 18 01:36 AM
    Alzheimer Drug Fails Trial [view article]
    If you read the study results closely, the improvements noted did not mean the patients improved at all, but that they declined less rapidly than the control patients. If BAP can remove the "plaque", it needs to be done very early in the disease so as not to cause "Brain Swelling"...so, BAP may be helpful in the very early stages to prevent AD, or stop it early. But, I think what we're seeing is that if too much plaque is removed, it becomes very dangerous and risky.
    What about Perispinal Etanercept? Why wasn't this studied since the results of the Phase I clinical trial showed actual improvements in Cognitive Ability and has maintained the progression of the disease in some patients for over 3 years? Somebody needs to get on this!     Reply
  • commenter
    delta7777
    Jun 15 11:54 PM
    Elan, Wyeth Take an Inside-Out Approach to Alzheimer's Vaccine [view article]
    jarcom--you say "An alzheimer vacine....simply panovian. AHP used to be smarter than to go for such stuff."-----are you perhaps suggesting that AHP was "smarter" in its fen/phen days???? Reply
  • commenter
    Laura P
    Jun 15 11:43 PM
    My Website
    Elan, Wyeth Take an Inside-Out Approach to Alzheimer's Vaccine [view article]
    * "Any sort of vaccine could induce that vaccination-- ACN-1792 was stopped in its tracks in pIIa because of that very inflammation problem."

    Replace "vaccination"... with "inflammation.&qu... My bad.
     Reply
  • commenter
    Laura P
    Jun 15 11:36 PM
    My Website
    Elan, Wyeth Take an Inside-Out Approach to Alzheimer's Vaccine [view article]
    My humble opinion: Immunotherapies in the brain are dangerous and can go wrong, wrong, wrong. That being said, passive immunization (antibody administration-- AB-001) is much better than active immunization (eliciting a response to an antigen-- AN-1792 and ACC-001).

    The brain, as I'm sure you know, is an "immuno-privilege... site-- that is, normally immune cells never enter the brain unless explicitly instructed to do so (e.g. with a vaccine). Leukocytes are not "trained" not to react to brain antigens they way they are with almost every other antigen in the body so the brain doesn't become the accidental target of damaging inflammation. Any sort of vaccine could induce that vaccination-- ACN-1792 was stopped in its tracks in pIIa because of that very inflammation problem.

    Elan is all excited because, even though their active vaccination didn't show much in the way of cognitive improvement, iautopsies of dead patients pII trials showed plaque regression. However, replacing one neurological disease with another isn't ideal and would probably only be OK'd for extreme cases. I am unimpressed.

    The passive vaccination (AB-001) is safer, and indeed it seems to work better (even though in my opinion it's still risky). Nonetheless, passive immunization is not nearly as sexy as an active immunization that could work prophylactically to cure Alzheimers like we cured Polio. The word "vaccine" has people all excited when perhaps they shouldn't be.

    Even passive immunization to beta-amyloid, though, vaguely misses the mark. It doesn't nip the problem in the bud. A secretase inhibitor-- something in Elan's pipeline-- would be able to nip the problem in the bud. However, it's years and years away...

    I'm intrigued and think that perhaps I will write up a full review of immunotherapies for Alzheimer disease... bestofbiotech.wordpres...     Reply
  • commenter
    jarcom
    Jun 15 10:52 PM
    Elan, Wyeth Take an Inside-Out Approach to Alzheimer's Vaccine [view article]
    An alzheimer vacine....simply panovian. AHP used to be smarter than to go for such stuff. Reply
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