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Icicle

Icicle
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  • MannKind: Is It Going To Soar Or Plummet? [View article]
    Up there with Fearstain for comedy.
    Jun 30, 2014. 09:52 AM | 3 Likes Like |Link to Comment
  • FDA Advisory Committee Recommends Approval of AFREZZA(R), MannKind Corporation's Investigational Drug to Treat Diabetes [View article]
    Joe, if you ever get to Atlanta, me and Hubby owe you dinner!! A biiiiiig dinner.
    Apr 1, 2014. 06:30 PM | 1 Like Like |Link to Comment
  • How big pharma sells A.D.H.D [View news story]
    I have ADHD. I lost 43 cell phones before I started treatment, not lost anything since. I'm staying on the meds.
    Dec 15, 2013. 05:44 PM | 5 Likes Like |Link to Comment
  • BofA downgrades MannKind [View news story]
    Would this be the same BoA who lost gulf war soldiers wages en route to their bank accounts?
    Sep 6, 2013. 09:40 AM | 1 Like Like |Link to Comment
  • 6 Reasons ImmunoCellular Therapeutics Is One Of The Best Risk Vs. Rewards In The Market [View article]
    Is there some reason you can't use PSA as the biomarker?

    Having said that, and assuming I had a prostate, Provenge is the last thing I'd use.

    Oh wait. From Wikipedia..

    [Provenge] ..patients have usually failed primary treatment of either surgical removal of the prostate, (EBRT), internal radiation, BNCT or (HIFU) for curative intent..

    OK. Its the third last thing I'd use.

    Is it true guys in the Provenge placebo group had their white cells removed??? Did they agree to that? I would say that's tantamount to murder in a cancer patient, except destruction of the immune system seems to be standard practice anyway among the nuke and puke set.

    To pretend to take white cells is one thing, to actully do it, in an elderly cancer patient, with no prospect of any therapeutic benefit thereby is the worst case of clinical negligence I ever heard of and I survived the NHS so I know all about that.

    Someone needs stringing up.
    Aug 16, 2013. 09:33 AM | 1 Like Like |Link to Comment
  • 6 Reasons ImmunoCellular Therapeutics Is One Of The Best Risk Vs. Rewards In The Market [View article]
    Where I was going with that is that there are other antigens and other cancers. There will come a point where all of them can be programmed into the immune system of a patient, at least in theory.

    Perhaps the reason that not all patients are cured already is that there are markers in GBM not targetted by the vaccine. either newly appeared, or there all along.

    What I am also wondering is if there are cancers that only have markers normal cells have. If not, them eventually it is game over for cancer. It becomes a chronic disease.

    That would be so helpful for more than cancer.

    I use herbs and OTC meds against many illnesses in pets and family the doctors and vets gave up on. There are several I would like to use from time to time to help with tissue repair. I can't use them as I know full well if there is any undiagnosed malignancy there the stuff would make like Miracle Gro.

    I spend forever and a day checking every last thing against every last signal transduction pathway and half of that is checking on cancer. I would like to spend less time at that, so here's hoping :)
    Aug 13, 2013. 01:50 PM | 1 Like Like |Link to Comment
  • Finally! Electroporation Is Being Noticed By The Street [View article]
    If that worked, it would be carcinogenic.
    Aug 9, 2013. 09:27 AM | Likes Like |Link to Comment
  • 6 Reasons ImmunoCellular Therapeutics Is One Of The Best Risk Vs. Rewards In The Market [View article]
    It occurs to me that as cancer cells are about 100 times more likely to mutate than other cells that the immune markers, specifically the antigens might change over time. It might be worth doing a new biopsy once a year. Also I think there are about 75 known immune markers. I wonder if there are any plans to just bung the lot of them in one vaccine. Well OK that might kill the patient, but you can see where I'm going with that one..

    Thanks Joe for an informative article. I can see why your pieces take so long to write, and I expect finding out about these things is beneficial for us all even were IMUC to tank tomorrow.
    Aug 7, 2013. 01:02 PM | 1 Like Like |Link to Comment
  • I Am You See [View instapost]
    Assuming cancer stem cells start the tumor off then hide inside it, I should think anything that targets cancer stem cells would work best at two stages - 1) before you even know you have cancer and all there are are stem cells 2) after conventional therapy has killed or removed the non-stem cell part, or even most of, the tumor.

    There are many adjunctive therapies that might also help such as DCA, CoQ10, curcumin, inositol hexaphosphate, liposomal or IV vitamin C, (plus the conventional chemos but I know next to nothing about those as I have a horror of killing off the immune system unless there is significant survival advantage).

    One approach to cancer that is often taken is to prevent angiogenesis, that is, prevent the tumor forming itself a new blood supply (anti-angiogenics include thalidomide or bindweed extract). It might be helpful, however, to take the reverse approach when using stem cell marker immunotherapy for two reasons 1) I heard somewhere that a tumor that can't make a new blood supply is more likely to metastasize (send out cells to make new tumors) 2) to get the immunotherapy right inside the tumor via the new blood vessels and target the stem cells I presume are hiding inside it. Anti-fibrotic herbs or aspirin can help pick off any hopeful colonists.
    Aug 7, 2013. 10:13 AM | Likes Like |Link to Comment
  • Why Mannkind's Afrezza Will Fail [View instapost]
    You don't explain why Afrezza is 'doomed to the same fate'.
    Jun 21, 2013. 03:15 PM | Likes Like |Link to Comment
  • What We're Doing To Stop Stock Price Manipulation, And How You Can Help Us [View article]
    I agree with JHM, whose suggestion might result in flagging the likes of Adam Feuerstein and Martin Shkreli rather than removing microcaps.

    I'm a novice at all this, and those two jump out a mile.
    May 24, 2013. 04:00 AM | Likes Like |Link to Comment
  • Oramed Sweeps Past Worldwide Giants With The First Trial Of Orally Delivered Insulin [View article]
    Why did that happen anyway? I know it was something to do with a hedge fund manager Martin Shkreli, who is known to have shorted MNKD because he said so on his Twitter account, but why on earth would the members of the FDA feel compelled to listen to some young trader, who does not, as far as I can tell, have any medical background?

    What gives him such clout?
    May 20, 2013. 12:29 PM | Likes Like |Link to Comment
  • Oramed Sweeps Past Worldwide Giants With The First Trial Of Orally Delivered Insulin [View article]
    Think of the children?
    May 20, 2013. 12:27 PM | Likes Like |Link to Comment
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15 Likes