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James Althof

James Althof
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  • Ready For A Rebound? Gilead's $1000 Pill [View article]
    Good article. For those readers who object to this Hep C pill because it will someday come out of their pocket, "just to save the life of some immoral low life," really miss the point. Molecular bio-genetics are the technological advance equivalent to man learning to use fire or put a keel on the bottom of a boat. I am sure the first fire user burnt himself and many boat models sank. Those "disruptive" people were likely condemned for offending "the gods."
    The bio-mechanical concept of this drug has hundreds possibilities for the treatment of the human livers, even the livers of God fearing...good and worthy people! It is like the first working wheel...it was the "evil spore" that drowns our civilization in wheels with millions of types. The real problem with quality standards that are only as narrow as the next quarter's earnings, will always impede substantial breakthroughs, keeping all of us away from the fire's warmth.
    Actually, Hep C , continues to infect medical workers at a high rate, innocent blood product recipients, sons and daughters who get their first cool Tattoos, most inmates, a very high % of Correctional Officers, you and I, our parents. You see, this is the "first wheel" in the treatment of liver problems. Eventually the children of this single intervention in the liver will produce cures (as in CURES, I say boy...CURES.) for the existing epidemic of cholesterol problems and the hundreds of thousands of down stream diseases from them. If you cannot get the immense profit leaden benefit of mankind getting there, please pay your Congressman to bray out against the flood of new CURES that may cost $1,000 a pill, but like the first Ford, become ridiculously cheap.
    I wish there was a law that required knowledge as a requirement for the freedom we have to run our mouths.
    Apr 17, 2014. 12:29 PM | 5 Likes Like |Link to Comment
  • Biogen's Winning Strategy [View article]
    I would love to see some Tx cost comparisons. Existing Rx's for Hep B,C Cancers are rated in number of days that patient is alive. Costs are astronomical and are essential palliative care. The new molecular drugs are now being rated for their CURE rates. Most oncology treatments are FDA approved 10-20 years ago. Lung cancer treatments average 3-6 week extension of life. Life-long maintence treatments produce remissions at best, but I have yet to see a cost savings comparison of our new breakthrough Rxs.
    Mar 27, 2014. 04:16 PM | Likes Like |Link to Comment
  • FDA New Molecular Entities - Finding Them Ahead Of Approval But Also Ahead Of The Herd [View article]
    There appear to be three to four medical paradigm changing platforms that will change medicine forever. These are "Black Swan," or "destructive technology" conceptual breakthroughs that will bring astounding changes in the Clinic between 2014-2017. Most of these new treatments could probably be called sub-straits of New Molecular entities, (NME) as the FDA calls them; however the fact that NME is in the center of the FDA's radar, accompanied with breakthrough "Red Tape," reductions like "1st-in-class or an Orphan in its impact on public health, and novel approval methods (Fast Track, Breakthrough, Priority, Accelerated ." This bureaucratic change and the new legal protections for data sharing are shockingly foresighted. Ten years of post Genomic Project research is producing conceptual change about diseases, that are the equivalent of Physics's Theory of Relativity to Swiss Clock Making in advancing science. This article is one of the best and most revealing: use these methods for sorting out the growing web of Molecular lab contracts, for only several of these companies own the underlying patients that the second and third tier companies will market. Excellent work.
    Mar 18, 2014. 01:30 PM | 1 Like Like |Link to Comment
  • Yahoo sued for scanning emails [View news story]
    And then there is history, which has repeated itself when it comes to oligopolies, monopolies, and totalitarian requiems. These events always tilt the scales of justice and equality, first by taking control of the population and that is proceed by a massive infrastructure of data collection and spying. I will remind you that Hitler's precursor to the Third Reich was through the creation of The Department of Homeland Security. Seriously, that is what he called it. What Osoma Benlaudin knew about the US is the paranoid core of our military-industrial complex. I just got off a domestic flight....250 people were still removing their shoes, getting full scans producing a detailed picture of their nakedness, throwing away all liquids over 3 oz. emptying their pockets, using only baggage which is precisely sized, paying extra for leg room, having all their electronics scanned and or shut off. Osoma's ghost is on every flight, every airport, every post office, every email (Hi NSA, I hope you are enjoying this blog.)
    This is essentially out of control Search and Seizure. Marketing and big business collects and profiles us for a profit, Big Government encourages and uses it, views it, collects it and run the biggest prison population in the world!!!. Come on! Your existence and all evidence of it is your property. They claim that they have stopped 10 plots of terrorism, which they labeled, they decided, and they and only they have the probable cause information which is Classified Data. Believe it or not, I am a conservative in a crowd with George, Thomas, Abe, Harry, Ike, a bunch who were aggressive personal rights believers. Many of you will discover, invent radically new things: "disruptive technology." you may never profit from it, or even see it make life livable for free, because it takes the brains of a flea to predict your future creative property, if they have your data analytic profile...and they do have it, identity thief is the least important thing that some outsourced data analyzer could steal from you in the future. Snowden did it, so far, we havent caught his colleagues who are doing the same for personal profit. :)
    Jan 2, 2014. 01:43 PM | Likes Like |Link to Comment
  • Yahoo sued for scanning emails [View news story]
    I hear this dismissive remark from Millennials, Gen x's and Y', all the time.
    " DEAL WITH IT DUDE, EVERYONE KNOWS THAT ANYTHING ON YOUR PHONE OR INTERNET is being recorded!"
    But, just because Big Data's presence has accreted on to all of our possessions over the last 20 years, does not make it JUST or , it merely makes it common place. However, everything we think,or do is driven by an energy burning body; which you cannot sell nor can it be taken away from you. It is, in short, your property. Culture CREEp is only noticeable when it happens suddenly, e.g. like if last night Heinz 57 painted you car because they want your ad space, or Google loads its Google Map tower with technology which hacks your WiFi encryption. The Supreme Court, in 1978 reaffirmed our Second Amendment Rights: it guaranteed that "Anything under the sun....that comes from the hand of man, whether of value or is of no sensible value, is his/her propriety right."
    Think about it: 1. you pay a fortune for your Tablet, smart phone, computer, and now every device in your home. 2. you pay for the transmission of anything you do or say or watch on cable,tower,bluetooth. (at this point, these EM wavesshould be your personal space, your property) and 3. then you use your body,mind, actions, which is functioning on >$150.00 of groceries, healthcare, utilities, rent, a month to Move, Think, Create, Mate, Scribe, Shop, drive or walk, socially connect with others and anything else you or your mind creates at the moment. So, if you paid for everything it takes to behave, which when recorded, make data points and provide ad space, to whom does the record of your behavior really belong? ............YOU! You paid for it, you used it, and therefore, all of your behavior belongs to YOU.
    So what! Well, for one thing, someone is making a fortune from using your property. But, more importantly, your future behavior can be predicted for the record of your behavior. Zuckerberg and his buddies were goofing-off when they launched the "Grandmother of all Social Sites: Facebook. Bill Gates was hanging with some of his friends at Xerox, when he saw the first Windows Touch screen and walked out the door to make Billions. Apple did this same tour.....the rest is history. The physicists that made the Atom bomb, hung out for laughs at lunch, published private papers, shared ideas, until the Gov decided a bomb would be a good thing and made them stop using anything that was recreational and hide them at Oak Ridge or Los Alamos. If Big Data had the information on these people that it has on us, predicting their inventions and taking them is like falling off a log. It wont be long before "Our behavior is Our property," will arrive at the supreme court.
    Nov 18, 2013. 11:00 AM | 1 Like Like |Link to Comment
  • How To Get Direct Exposure To Big Data [View article]
    I suspect that the long term tolerance for profit making from behavior and thinking paid entirely for by individuals who generate it, will put a stop to data collection and data of their proprietary products. Just like patients, copyrights, and personal property, there is substantial legal precedent which presumes that behavior and thinking produced at an individual's own expense is their property and cannot be used or sold without their permission. The logical extension of stealth data collection and manipulation of the individual through analysis of data on their behavior; without legal rights to do so, has no limits. For example, using your cell phone, tablet, TV using your data file is not different from using any of your property. Wait until you go to your car, just to find that it is covered with ads from Tampax, Trojans, Heinz 57 and any other product that ad sense has detected. Then there is personal crime, 90% of which is preceded by profiling the habits of victims and predicting their next move.
    Nov 5, 2013. 02:33 PM | 2 Likes Like |Link to Comment
  • Keep One Eye On Google's Secret Weapon [View article]
    In the last several days, my Google browser have been slathered with what they refer to as behavioral advertisements and explained to me how happy I was, because they had taken it upon themselves to compile a list of activities, thoughts, places that I had surfed and were now finding companies which provide those products. If you want to laugh, they have crude merchant linkages to the products that my mouse may have paused on. Did you know that you can get tattoos and adult toys at .....Walmart, Target, gg Hegg, TJ Max and three of my local restaurants!!!! Now let me see, I pay for my cable, I pay for my computer, I spend my free and work time on these subjects, and I buy the food which enables me to set in a home for which I pay the utilities, and have furnished. Upon my property, they have trespassed all over it. This attitude is spreading, The amount of time on FaceBook is decreasing 20% a quarter, start up companies that run ISPs from their servers that cut out all cookies, key loggers and outside data analytic companies. No do doubt the american publich will become quite ingenious at misguiding and thus crushing this intrusion on our property and personal space
    Apr 25, 2013. 03:23 AM | Likes Like |Link to Comment
  • Reinhart-Rogoff A Week Later: Why Does This Matter? [View article]
    A group of professors from Sanford, Harvard, and other significantly credentialed economists and statisticians, have acquired the data which is fueling the GOP that Government Dept has caused and will continue to extend this already lengthy recession. The logical flaw, they discovered was based on the idea that correlation is casual, and that when you clump historically high debt to GDP in to groups which are incomparable, you arrive at the conclusion that high government to GDP delay and prolong recessions. one month of Belgium was equated to 9 years in the UK and loads of other gaps in the sample were manipulated to support the pre-supposed conclusion. A reanalysis across several different disciplines at three independent Universities, clearly shows that Governments which applied a 90% government debt to GDP early in a Recession, reduced the level of unemployment at a faster rate, than countries who either used less debt in the beginning of a recession or delayed their application. Their data, reanalyzed using scientific standards, by highly credentialed academicians arrive at just the opposite conclusion than the fiscally conservative GOP.
    Apr 24, 2013. 11:36 PM | 2 Likes Like |Link to Comment
  • The U.S. Economy: How Did We Get Here? Where Are We Headed? [View article]
    This one of the first articles which uses both a historical and a data base approach to our "stuck" economy.It is a refreshing grasp at reality.
    All the responses which use name calling and hyperbole are the primary reason we are gridlocked with this problem.
    What we all need is a clearer picture of all of the casual variables that led to our current situation and we need an accurate view of the way they have interacted to bring us to this state.

    First. Like them or not, business is always on the short leash of demand, Demand means cash in hand, and it the "dead peasants." who have the demand and hold the leash. Oligarchy will never trump viable demand even with years of conspicuous lobbying. An we have a substantial number of people who no longer have jobs what make cash. (historical data on in-country investment of capital goods, number of work stations, and global out-sourcing, cheapen down the goods and the work force became a data/informational nation, thus covered this up.
    Secondly, several historical variables are missing above. One, is the decline in in-country investment in capital goods. Another, we cannot leave out the growth of the global economy and its rapidly advancing educated middle class. Outsourcing was camouflaged until we could no longer keep the data/information industry here which took the place of manufacturing. Which occurred in the years in the first chart before this recession. During this recession, one of the most profitable companies have been the magt software companies. Spending increased as profits and revenues decreased. This created a vacuum of local data jobs which were not there when it was time to put people back to work. .

    Thirdly, we fail to include in our historical analysis the substantial change in composition of our workforce beginning in the late 1950s when families sent out two working adults causing an explosion in new (costs that did not exist before) expenses to the average family in order to work. As a result, we have been running backward in terms of excess income and using personal debt to cover our short fall. Housing and credit cards filled in the personal deficit to drive consumption and inflated personal assets.
    Fourth, just a we most needed patriots and statesmen in Wall Street, we got a wave of the greediest deceivers and law breakers yet to knock us down with deceptive trading and sub prime fraud. What business really needed, the funds of the "dead pheasants" who took Trillions off of the fraud riddled, electronic trading floor and hid it in Treasury bills and coffee cans. 3-6 Trillion back into equities could capitalize a robust re-start, but Wall Street cannot stomach law and order which could replace the unfettered chaos which slung shot us into this recession.
    Finally, this moral deadlock over govt debt vs balanced budget is an issue that is the figment of frightened minds. It is a non-issue, tied to opposing money management views. The real issue is not to spend and not to conserve; it WHEN TO SPEND AND WHEN TO STOP. Scientifically done analysis of Govt Dept to GDP historically demonstrates that countries in recession which allowed their Govt Debt to rise to as much as 90% of GDP, were both successful and failed. The failures was due to fear of dept, causing a delay of Govt infusion of funds into the hands of "dead peasants", whereas, fast Govt dept infused, demand into the economy and decreased unemployment to normal levels is half the time. Thus stopping Govt expenditures and reducing its debt through tax revenues and a restrained budget.
    So which comes first, a car or a job? To get a job, you have to take the debt to buy a car so you can get a job and keep it.
    Apr 24, 2013. 09:13 PM | 2 Likes Like |Link to Comment
  • Can Industrial Automation Solve China's Demographic Challenge [View article]
    Yes, this presents a fundamental problem: can a free enterprise economy function without economic demand (a large group with spendable cash)? It has depended upon this exchange cash-back , demand loop since ...say the middle ages? In this closed loop, Power, Industry, stock owners, and the wealthy, ultimately hung by the thin string of a large middle class with cash demand (people who earned a living with surplus income).
    The U.S. loop has been increasingly broken (diverted) beginning in the 1990's, when the amount of capital expenditures invested in the U.S., began a decline that soon accelerated to the inverse rate of our great age of industrialization in the 1800's. The U.S. cross over point occurred in 2000-2003. Until then, Middle Class income grew at the same rate as the Upper classes ; since then it has turned abruptly flat and has slightly decreased (so did the expansion of real economic demand in the U.S, but disguised by two income families, increasing personal debt ($10,000+), and housing inflation)
    On the side of real wealth growth,surplus income growth has continued on the same upward rate that looks exponential.
    Now comes 2006-08, a sub prime recession that is trying to squeeze re-employment out of a land that sent its jobs away and/or automated them. The increasing amt. of recovery time with each recession, correlates directly with the decreasing capital expenditure invested in the U.S.
    So all levels of socioeconomic status in the U.S. is screwed, trying to make an economic model work where the cash demand loop has been eliminated within this country. Wealth accumulation continues in multinational companies which replaces American middle class demand with ex-american demand. Such micro-interpersonal bitterness has erupted. Personal blame slues between classes caught is a macro-economic crisis. The problem has been obscured :How does a free-enterprise economy function when it no longer has a demand base?
    Feb 14, 2013. 04:05 PM | 1 Like Like |Link to Comment
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