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  • Vivus Looks Into European Approval As Company Pins Hopes On Qsymia [View article]
    Qsymia is a dangerous drug causing increased heart rate, cardio-vascular events and birth defects. It was irresponsible beauracratic
    decision to approve it. These are the facts about Qsymia that no person should ignore.
    Aug 8, 2012. 11:19 AM | 9 Likes Like |Link to Comment
  • Arena Pharmaceuticals' Lorcaserin Will Be A Blockbuster Drug [View article]
    Lorcaserin's rat tumorigenesis has prolactin-induced MOA. Larcaserin is serotonin agonist. They are known to increase
    pituitary prolactin levels, and transiently - circulating prolactin
    levels. The fact that plasma prolactin levels increase transiently
    and level off is an advantage of Lorcaserin, not a disadvantage
    as some attempt to portray. The fact that SD rats developed
    benign and cancerous tumors (with only benign tumors numbers
    being statistically significant) can be safely attributed to prolactin MOA in rats where age of the animal, and prolactin level induced,
    and prolactin sensitivity, are of utmost importance. With safety margins following re-adjudication, and blockade studies that clearly demonstrate prolactin MOA, combined with available studies worldwide and total body of scientific evidence that was published
    for past several decades - there is no reason to not approve Lorcaserin. Especially when far more dangerous Qnexa was
    recommended for approval on miscalculated oral cleft number.
    Mar 1, 2012. 12:08 AM | 4 Likes Like |Link to Comment