User 172200

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    • Johnson & Johnson Must Acquire Small Pharmas to Ensure Future Growth [view article]
      JNJ SHOULD move higher into the 70s within a year .. Why ? : -"The Right demographics"-&am... well known products, Large international participation , Nice dividend that Grows EVERY year 10-12%, Predictable earnings Growth, Diversification, Solid management .... What's not to like ?? Apr 06 07:45 PM
    • Merck, Schering-Plough: Confessions of a Vytorin Patient [view article]
      Plaque REMOVAL ? My understanding : - The pathologic sequence that eventually causes severe artery narrowing, then occlusion, occurs in stages and over extended periods of time. Some of this "build up" involves an interruption of the endothelial - intimal surface by cholesterol and associated inflammatory tissue that becomes progressively more chronic over time, narrowing the lumen and in some instances calcifying. The latter described effects would not seem reversible. It would, therefore, seem that statins work by prevention of the inciting inflammation and inflammatory sequelae. Apparently, there is some evidence of clearance in some cases of more recent acute atheroma build up if the statin dosage is quite high and therefore putting the patient at some increased risk. Summing up : - We're back to the prime current indication for medication use - to reduce the LDH to as LOW a level possible WITHOUT putting the patient at risk . VYTORIN is certainly one medication that accomplishs this quite effectively for large numbers of patients that have been taking it ! Apr 05 10:16 PM
    • Merck, Schering-Plough: Confessions of a Vytorin Patient [view article]
      Dr Josh ! Yeah .... well Enough of this dueling over silliness .... Once your LDH settles out at 60 or below you reach such a sublime a feeling of WELLNESS ... Just hard to describe ... Like levitating ..... The only challenge remaining is to try and convince others to experience the same !! Apr 03 05:18 PM
    • Merck, Schering-Plough: Confessions of a Vytorin Patient [view article]
      DR JOSH ! Welcome! Hey ! Your own guys ( NEJM Articles) when "pushed by the facts", recommend to their patients Vytorin if their previous medication was ineffective in LDH lowering !! Hey (again !) YOU should know ( As I certainly do, being an MD) that there ARE out there, a hell of a lot of folks that don't tolerate increased statin dosage! Like chemist10 & others I enjoy the relative safety with Vytorin of having my LDH at 60 ( from 100+ after years on Zoccor 40mg alone. Please also read the AJC article ( June 15, 2007) referred to above !! Apr 03 01:55 PM
    • Merck, Schering-Plough: Confessions of a Vytorin Patient [view article]
      Enter your comment here Additional comment: - Interesting that the Cardiologists participating in the New England Journal of Medicine articles conclude in effect : - If your present medication is not effective in lowering your LDH - THEN Vytorin is recommended. ( My interpretation of this "double speak" : - Vytorin is a superior medication! ) Apr 03 12:24 PM
    • Merck, Schering-Plough: Confessions of a Vytorin Patient [view article]
      Still ANOTHER interesting article - AJC :june 15.'07:1706-1713 - "In conclusion, the lipid modulating and anti-inflammatory effects of ezetimibe/simvastatin provide ADDITIONAL benefits NOT realized by statin monotherapy alone" As far as "proof" that Vytorin lessons the incidence of heart attacks & strokes: I feel it could be reasonably assumed from the literature, that a medication both having the statin anti-inflammatory AND LDH lowering effects should be cardiovascular protective (like the different brands of aspirin) No doubt follow up research will substantiate this point. Disclosure I am an MD with NO relevant pharma holdings. Apr 03 11:50 AM
    • Merck, Schering-Plough: Confessions of a Vytorin Patient [view article]
      I have been on Zoccor alone 17 years with my LDH reduced to about 100 ( many lab tests etc) I switched to Vytorin about 2.5 years ago .... My LDH dropped from 100+ to 60.( I wanted to lower my LDH WITHOUT increasing statin dose for fear of liver or muscle complication) I am not going back to Zoccor . A mountain of medical research tells me, in effect, to lower the LDH as much as possible. Inference in article in Circulation, that it does not take high doses of statin to obtain anti inflammatory effects ( Circulation: 117:379-387.) Apr 03 07:15 AM
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