razormdthe2nd

Generex Biotech's Oral-lyn Granted Special Access Authorization by Health Canada

...for "Lanster" -- GNBT's pipeline?...you must be joking...one week they're working on a SARS vaccine...the next week it's a prostate cancer vaccine...then they start up RNAi program...whatever is in the headlines on Monday will be in their "pipeline" by Friday...years ago used to claim they were working on a fentanyl and a morphine spray -- they're both still listed on their website as being in phase I but they never mention any progress with either one anymore...their "pipeline" probably serves no other purpose than of duping naieve investors into buying their stock...in 2005 they had about 35 million shares outstanding; in 2007 that had risen to ONE HUNDRED AND TEN MILLION SHARES!...and per the accountants on the annual report:

"These matters raise substantial doubt about its ability to continue as a going concern."

...you figure it out!

Generex Biotech's Oral-lyn Granted Special Access Authorization by Health Canada

HAW!...yet another try at a pump from an anonymous investor!...evidently GNBT managed to convince a GP to presribe oralyn for ONE -- strong emphasis on "ONE" -- patient...and SAP authorization does NOT mean other therapies "either failed, were unsuitable, or are unavailable"!!...altho... that was its original purpose it is used to obtain pretty much not currently authorized -- e.g. silicone BREAST IMPLANTS:

www.cmaj.ca/cgi/conten...

...nothing changes the FACT that the bioavailability of insulin via oralyn is only about 5-7%...in other words, the same quantity of insulin via oralyn per DAY would last 16 - 20 DAYS if given via injection...moreover, the patients would STILL require injections since oralyn is short acting and virtually ALL patients require some form of long acting insulin...and if they're afraid of needles there are needle-free injection systems available -- e.g. medi-jector...GNBT claims to have been selling oralyn in Ecuador for over a year and a half now but have yet to report a single PENNY of revenues there!...GNBT is NOTHING but a bad Canadian joke that is run by a former real estate agent.

Generex Biotech: A Breath of Fresh Insulin

...my most recent post from Yahoo's GNBT board:

"first, I posted this about 9 months ago:

messages.finance.yahoo...

...well, danged if old "Ismael" didn't provoke a response:

www.thediabetesblog.co...

...it's too LONG to post here but apparently the blogster turned around and contacted GNBT's manager of "regulatory affairs" and asked if "Ismael" had a point...and the manager wrote back:

"The product, Glucose RapidSpray™, is to be taken at the first sign of needing additional glucose in the diet, either between meals, during exercise, and/or before bedtime. It is not intended to take people out of full hypoglycemic states that normally a full tube of glucose gel or a full dose of Glucose tablets would be needed for. Glucose RapidSpray™ product is meant to be a complement to meals in order to help with glucose levels. As such, a direct correlation of carbs associated with Glucose RapidSpray™ and typical glucose tablets or gel is not warranted based on the intended use of the product. If usage of the product is maintained by taking Glucose RapidSpray™ at the first sign of needing additional glucose, then the Nutritional Facts stated on the package labeling is adequate for determining caloric intake (be it 5 sprays, 10 sprays, 15 sprays or whatever is taken to address the situation)."

...how stupid could the author possibly be?...the "first sign of needing additional glucose" is also the first sign of hypoglycemia!!...but then he admits that it's not intended to treat hypoglycemia...BUT he DOESN'T address the issue that the label misleads the prospective customer by NOT clearly stating that it's not intended to treat hypoglycemia and by calling itself "rapidspray" which implies something to be used when a rapid response is necessary -- as in hypoglycemia!...to my utter amazement the blogster actually complements GNBT's idiotic response:

"I consider the proactive response of Generex a good sign of how a company is run. Without needing to do so, Generex went above and beyond the call to address an open forum about the efficacy and accuracy of the product. This is the kind of interaction that convinces me a company cares!"

...fortunately, "Ismael" responded also -- part of his response:

"It sounds like they are marketing it as working faster and having a lower calorie count than glucose tablets. Why would they suggest that glucose tablets are large and gels are messy if not to offer their product as a replacement?

The low calorie claim comes from recommending an absurdly low serving size (less than 1/5 of 1 gram of carbohydrate), which is unlikely to have any noticeable effect on a user's glucose level. If you increase the serving size to a quantity that could reasonably aid you in combating the "symptoms of low blood sugar", the calorie count does not differ significantly from that of glucose tablet.
I have yet to see this in a pharmacy, but especially if Glucose RapidSpray is being displayed alongside glucose tablets and gels, I think the labeling and marketing of the product is dangerous. If Generex doesn't intend RapidSpray to be used to treat hypoglycemia, there should be an easily identifiable warning on the packaging indicating as much."

...go "Ismael"!...I just keeping hoping to one day turn on the TV and see Anna in an orange jumpsuit with handcuffs and leg irons doing the "inmate shuffle" as she's led before a judge...that'll be a GREAT day!...HAW, HAW, HAW!!!

Generex Biotechnology: Oral-lyn Buccal Insulin Takes Center Stage

Want to read another of my "razormd" GNBT posts from Yahoo:

Jul-24-07: ""The nutritional label on the product (available as a PDF on their web site) says the product has 188mg of carbs (or .188g) per serving (5 sprays). A typical glucose tablet has 4g... that's about 21x more carbs in a single glucose tablet than in 5 sprays of RapidSpray. Considering you typically use at least 15g of carbs to treat hypoglycemia, you would need around 80 sprays to get 15g of carbs into your system! When you take into account the amount of sprays you need, the calorie count isn't very much different from glucose tablets.

Read the label carefully, and be very careful using this!

Posted at 2:46PM on Feb 23rd 2007 by Ismael"

...BUT he got his math a little wrong, I think...it takes 80 SERVINGS to get 15 grams of glucose from "rapidspray"...at 5 sprays PER SERVING it would take about FOUR HUNDRED SPRAYS to get 15 gms of glucose!!!...HAW, HAW!!!...I can just imagine some poor diabetic with sweat pouring off him pumping away frantically before he passes out!!...on the other hand he could have just chewed 4 glucose tabs costing about 50 CENTS and saved money and a trip to the hospital...the quote is from:

thediabetesblog.com/20....../ "

Generex Biotechnology: Oral-lyn Buccal Insulin Takes Center Stage

And don't forget GNBT's generous board of directors:

AUG-23-07: "HAW!!!,,,it must be...sweet being Rose and Anna!!...from the 8-K:

"The Board of Directors also awarded retroactive salary increases to the above-named executive officers of the Company as follows..."

...375,000 FREE shares PLUS retroactive pay raises!!...HAW!...I can just hear Anna and Rose singing in the shower: "ROLL'EM OVER, ROLL'EM OVER!!...SCREW'EM AGAIN, SCREW'EM AGAIN!!"...HAW, HAW, HAW!!!"

...and to think Anna was a real estate agent before becoming CEO of GNBT!...ain't life grand?!

Generex Biotechnology: Oral-lyn Buccal Insulin Takes Center Stage

But let's not forget pertinent details:

14-Aug-07: "Now let me get this staight...each cannister of oralyn contains 400U of insulin...and 1 puff = 10U of insulin...but 10U actually only equals 0.7 units of injected insulin...so each canister actually only equals 28U of injected insulin...now let me think about this a minute...uhhhh, a type 1 diabetes patient typically requires an insulin dosage of about 1.0 unit per kg per day...so a 70 kg person needs about 70 units and that's typically divided 50% NPH and 50% R...so a patient would need 35U per day of humulin R...but each canister has only the equivalent of 28U of humulin R?????...so a typical patient will use a canister or more a day??????????...HAW, HAW, HAW!!!...sure hope those canisters are recyclable!!...HAW, HAW!!...and let's see, humulin R runs about many bucks per hundred units -- wonder what insurance companies would say about a patient flushing all that perfectly good insulin down the toilet every day?...HAW, HAW!!!...Anna rocks!!!...HAW, HAW, HAW!!!!"

Generex Biotechnology: Oral-lyn Buccal Insulin Takes Center Stage

Never hurts to take a close look at the distributors:

11-Aug-07: "Re: HAW, HAW!!!..."Leosons Overseas Corporation"!...I get it!...you mean the one with NO affiliates:

www.leosonsco.com/affi...

...the one with NO news:

www.leosonsco.com/news...

...is that the ONE?...HAW, HAW!!...and what's that you say:

"Our clients are located throughout the middle east far east Europe and in such countries as Bahrain, Qatar, Saudi Arabia, Kuwait, Yemen, Lebanon, United Arab Emitrates, Jordan, Egypt, Cyprus, Malta, Romania, and Croatia."

...wow, I'm impressed!...all those customers to serve and Leosons only has SEVEN employees?:

www.manta.com/comsite5...

...all those customers and Leosons has only 1.3 million dollars in annual sales?:

www.manta.com/comsite5...

...HAW, HAW!!!...of course, I guess the demand for hemmorrhoid anesthetic ointments isn't all that great, huh?:

www.leosonsco.com/prod...

...HAW, HAW!!!...1.3 million -- that's rich!!...no wonder you didn't pay an upfront license fee -- probably couldn't afford it!!!...HAW!...sure hope all those "costs associated with the procurement of governmental approvals for the sale of the product, including any clinical and regulator costs" aren't too high!!!...HAW!...maybe you can recoup some from "rapidspray" sales!...oops, maybe not:

www.leosonsco.com/getP...

...HAW, HAW, HAW!!!...Anna Rocks!!!...HAW, HAW, HAW!!!"

Oral Insulin: Balancing Safety with Efficacy

Anyone wanting the FACTS about GNBT should check my posts on Yahoo's GNBT message board...some of the things I've posted:

Apr-08: "GEN084-OL???...HAW!!.... cracks me up that the specific locations of all these clinical sites evidently is top secret!...goodness knows, they're scattered among cities from one end of the world to the other...but apparently no one is allowed to know the names of the hospitals, clinicians, etc that are actually involved!!!...goodness... a poor diabetic interested in participating to do?!!!...GNBT doesn't even list a phone number to call on their website!!...and isn't it interesting that "GEN084-OL" doesn't show up on any clinical trials databases?...gee, I sure hope Anna isn't committing fraud...I'd sure hate to see her have to go to prison!..."

1-Apr-08: HAW!!...one week GNBT announcesan "order" from India and a week it announces a "death spiral" convertible managed by that lone GNBT cheerleader: Rodman & Renshaw!!!...ain't it sweet!...Anna makes money...R&R make money...shareholders get -- uhhhh...well, you know...HAW, HAW, HAW!!! "


15-Mar-08: "Re: 25,000,000 yard sale.. who needs your approval?" ...this was in regards to notification of a future stock offering: "the best part is: "...for a price of not less than 70% of the market price at the time of such issuance..."...damn!..... I'd buy some if I could get it for 30% off!!...HAW, HAW, HAW!!!"

15-Mar-08 "HAW!...I see Bernstein grabbed... 15-Mar-08 05:16 pm ...a quick 50,000 share at 94 cents a share before bolting for the door:

yahoo.brand.edgar-onli...

biz.yahoo.com/e/080314...

...Amanatides left too?...HAW!...rats starting to abandon a sinking ship!...HAW, HAW, HAW!!

12-Mar-08: "HAW!!!...sweet 10Q!...wait a minute..aren't revenues supposed to be going UP????...I mean, after all, oralyn is selling like hotcakes in Ecuador and the Middle East, right??...and that koolaid spray they make is just flying off the shelves, right???...and old "Kaboom" is pumping people up everywhere, right???...but revenues DROPPED from 46,000 a year ago to 19,000??...well, at least those expenses keep going up!...wait a minute -- that's BAD, isn't it?...but, hey, I found one bright spot!!...the near exponential rate at which the number of shares outstanding keeps increasing means the loss per share doesn't look nearly as bad as it would have a few years ago!!!...HAW, HAW, HAW!!!"

11-Mar-08: "Re: GNBT Announces Phase III Started - When?...HAW!!!...don't get your hopes up!!...GNBT originally said they were starting phase III EIGHT YEARS AGO!...last year they said they would actually recuiting patients beginning in November, 2007...yet there is NO evidence they have recruited even one patient...they haven't even announced anywhere that prospective patients could go to sign up!...face it -- the company is a SCAM!...just another biotech playing smoke and mirrors in order to keep money flowing into management's pockets."

...make NO mistake -- this company is basically nothing but a hoax designed and managed toward ONE end -- selling worthless stock to naieve investors...AVOID!!!