ex-chem

Takeda Forced to Surrender DPP-IV Drug Market to Merck

>>>>even if you're selective for that one enzyme, it has a lot of other substrates. So the story may well swing back to the biochemical mechanism again before we're through.<<<&l...

Methinks we may have gotten a little too smart for our own good! The plethora of data available nowadays--mechanisms, substrate specificity, lack of specificity, multiple substrates, inconclusive mechanism of action, P450 interactions, metabolic insufficiency, CV risk in overweight patients, etc., etc.

It no longer matters that a particular drug candidate may actually produce a positive outcome for a particular condition--God forbid that grossly overweight, chain smoking, and generally unhealthy Ma Kettle should get a bunion while on her pharmaceutical regimen for diabetes! End of drug!

What do you think the chances would be of the FDA approving acetylsalicylic acid?