sal bando

Anesiva 'Pain-free' High Growth

why are you posting this crap here?


On Aug 25 01:38 PM Amartha wrote:

> I went to India for my hip replacement surgery. Actually it was not
> because of the money but endless wait that I had to do for my surgery
> at Charlottetown. I decided to do my surgery in India. I contacted
> a medical tourism company valuemedicare.com they were great.
> They helped me with everything. The standard of healthcare in India
> is much better than Canada and if you are suffering due to long wait
> time it is better to go there.

Anesiva 'Pain-free' High Growth

Recently, capsaicin is being tested for the prevention of pain post surgery. David Julius, a physiology professor at the University of California, San Francisco, recently discovered that capsaicin selectively binds to a protein known as TRPV1 that resides on the membranes of pain and heat sensing neurons. TRPV1 a heat activated calcium channel, with a threshold to open between 37 and 45 Celsius degrees (37 degrees is normal body temperature). When capsaicin binds to TRPV1, it causes the channel to lower its opening threshold, thereby opening it at temperatures less than the body's temperature, which is why capsaicin is linked to the sensation of heat. Prolonged activation of these neurons by capsaicin depletes presynaptic substance P, one of the body's neurotransmitters for pain and heat. Neurons that do not contain TRPV1 are unaffected.[9] This causes extended numbness following surgery, and the patient does not feel pain as the capsaicin is applied under anesthesia.

The result appears to be that the chemical mimics a burning sensation, the nerves are overwhelmed by the influx, and are unable to report pain for an extended period of time. With chronic exposure to capsaicin, neurons are depleted of neurotransmitters and it leads to reduction in sensation of pain and blockade of neurogenic inflammation. If capsaicin is removed, the neurons recover.