pharma's Comments

OPEC's Move to Devalue the Euro

Tue, 17 Jun 2008 23:28:15 -0400

So much wishful thinking...The author is a moron paid by the US Treasure.

OPEC will help America or US$? Get real. Do you expect much help from Iran and Venezuela?

Will Icahn Bail from His Yahoo Position?

Sat, 14 Jun 2008 13:32:15 -0400

Carl is not an investor. He is an extortionist. This how he has made his money with Mick Milkin help.

Yes, he tried to run business: TWA. It went into a bankruptcy and out of business in a hurry.

So, if Carl gets his wish taking over Yahoo with his own money, he will lose his ass. There are not too many buyers for Yahoo especially with cash to pay.

PS
In the present financial environment, there are not to many banks with a desire to lend him money for this kind of entertainment.

Is Lilly and Amylin's Byetta Better?

Fri, 13 Jun 2008 23:09:14 -0400

This AMLN pumping is just disgusting.

During the last 4 years company insiders received and cashed out huge amounts of granted options in spite of terrible sale or stock price performance.

AMLN has total disregard for it shareholders.

AMLN was burning money having huge expenses but their clinical trials looked more like Mickey Mouse trials with too few patients to be conclusive.

The last trial for LAR Byetta was a comparative trial with so few patients than it is impossible to make any definite conclusion regarding either Byetta or LAR Byetta efficacy.

Bernanke Seems Willing To Allow More Downturn Than Greenspan

Sun, 08 Jun 2008 22:13:26 -0400

It is so convenient to blame Nazi for everything.

Stalin and Mao have killed many times more people than A. Hitler.

Nazi did not invent extermination gas-chambers and concentration camps. Extermination gas-chambers were invented and widely used by Bolsheviks in 1920s. The first concentration camps were invented and used by British.

The real initiator of the WWII was not Hitler. The main driver forces behind the war were J. Stalin and FDR.

Yes, Nazi committed lots of crimes but during their colonial times British commited much more crimes specifically in India.

Finally, Americans use A-bombs to kill endless civilians in Japan. The plan B, if America did not have A-bombs, was to gas millions of Japanese.

So much about bad Nazi and good American.

Investors at Risk of Losing Everything

Sun, 08 Jun 2008 20:20:28 -0400

Obama is a black preacher. This is all one can expect from him outside of paying back for 95% of black votes he got during the primaries.

McCain is just outright dangerous: a warmongering scoundrel with no respect for the Constitution.

Is Oil a Bubble? Part 3

Sun, 08 Jun 2008 17:55:04 -0400

The old French saying: Each country has the best government its people deserve to have. No better and no worse.

It is just stupid to blame the Congress for high gas prices and dependence on foreign and unfriendly energy suppliers.

The US Congress just reflects the overall bankruptcy of the entire US way of life. Its moral, intellectual and economic values are in disarray and in crises. The degradation started at Lyndon Johnson "Great Society", and started to accelerate during both Clinton and G. W. Bush administrations.

The American consumer-consumption driven economic model is nothing more or less as a parasitic way of life using somebody else money without any intention to pay it back.

For the last 40+ years, America lived well above its means. It is a very long time; it could not last forever [similar to the Soviet Communist model], and eventually the time is up.

Just to blame specific individuals in the Congress and in the Administration is stupid. These scoundrels were elected by American people.

Now, America is about to start a transition to its new way of life. It will not be a painless transition. Just look at Russia. Ten years ago, Russia was in a terrible crisis. Now, it is one of the most dynamic and growing prosperity society.

America will survive. It will take some time. America will be a very much different country.

Yahoo Denies Poison Pill: Icahn 'Manipulates the Facts'

Sat, 07 Jun 2008 00:58:03 -0400

Carl Icahn and his associates are nothing more or less than scumbags destroying American most valuable high-tech and biotech businesses.

His damage is enormous. His objectives are to make a fast buck for himself regardless for damage he makes.

Just look at Biogen. It is one of the best biotech company developing highly successful drugs that save tens of thousands of lives. However, now, Biogen management must spend a lot of time and energy to defend itself from Icahn desire to ruin the company.

It appears that this corporate raider is responsible for more deaths and suffering than Osama Ben Laden.

Bristol-Myers, ImClone, Genentech Release Promising Data at ASCO

Wed, 04 Jun 2008 15:29:19 -0400

AX,

"Also we must not forget that when Mike Huckman asked at the ASCO the doctors if they would prescribe Erbitux to their patients the vast majority said yes. And the one that wasn't sure was from Canada."

It is important to mention that Erbitux is not available in Canada. Bristol (who does Erbitux marketing in North America) is still negotiating with Canadian government Erbitux's price sold there.

Bristol-Myers, ImClone, Genentech Release Promising Data at ASCO

Tue, 03 Jun 2008 23:34:23 -0400

Half-truth is bad. It is more bad than lies. But this is exactly what Jason Napodano provides his readers.

Yes indeed, in general ITT [intend to treat] patient population adding Erbitux to chemotherapy extended the overall survival rate to 11.3 months from the 10.1 months for chemotherapy alone.

But this is not the entire story. Flex trial patients population included substantially broader spectrum of patients than the Avastin trial Jason Napodano has mentioned.

So let compare apples with apples:

- the Avastin trial #E4599 was conducted exclusively in Adeno-ca lung cancer patients. Addition of Avastin to chemotherapy improved median survival rates from 10.3 months to 12.3 months. Furthermore, cancer patients in Avastin #E4599 trials were ECOG 0-1 [relatively "healthy" patients] compare with more sick FLEX patients with ECOG 0-2.

In these more sick Adeno-ca lung cancer patients, addition of Erbitux to chemotherapy improved median survival from 10.2 months to 12 months. FLEX Erbitux median survival benefits to more difficult to treat lung cancer patients were practically identical to Avastin.

- But it is not all. FLEX ITT patient population also included SCC- lung cancer patients. These cancer patients can NOT be treated by Avastin due to severe life-threatening side-effects. In this lung cancer population, addition of Erbitux to chemotherapy improved median survival from 8.9 months to 10.2 months.

- It is true, Erbitux did not work on Asian patients. Addition of Erbitux to chemotherapy reduced these patients median survival. Erbutux should not be used in Asian lung-cancer patients.

- Avastin and Erbitux belong to two different classes of drugs. Erbitux is a EGFr-drug. It offers substantial clinical benefits to only a select group of patients and no benefits to the rest. By identifying Erbitux-responding patients [like it is done using biomarkers in colorectal cancers], survival benefits offered by Erbitux are much superior to Avastin benefits.

- Finally, the latest Avastin clinical trials in lung cancer failed to show survival benefits. Consequently, effictiviness of Avastin in lung-cancer became an issue.

ASCO: Whose Presentations Look the Most Promising?

Tue, 27 May 2008 12:26:17 -0400

So called "analysts" are just spin-artists.

Kras data are extremely important since Kras-status will identify cancer patients who will greatly benefit from using EGFr drugs specifically Erbitux from ImClone.

Erbitux is a very expensive drug but it offers to select head & neck, lung and colorectal cancer patients substantial survival benefits, improved quality of life, and for some patients cancer-free survival and even a cure.

Knowing the Kras-status, physicians will be very much eager offering Erbitux to patients who will DEFINITELY benefit from it. This will establish Erbitux as a standard of care for these patients.

This will make Erbitux a mega-blockbuster. Note that Erbitux's worldwide sale is already over $1.5B.

Icahn Boosts Stake in Amylin to 6.5%, Seeks Additional Talks

Tue, 27 May 2008 00:20:58 -0400

I was AMLN's shareholders from 1998 until 2007.

AMLN's situation is very complex:
- its management is very greedy and incompetent
- Symlin is a niche drug as of now with very limited sale potential
- Byetta is their major product responsible for 90% of AMLN sale and it has a strong competition from Merck's Januvia. Byetta LAR is the most important AMLN program since Byetta competition is coming from all sides.

Finally, Byetta and Byetta LAR are partnered with LLY. This agreement is very complex and not in AMLN favor. In a case of AMLN is taken over by other company, LLY has rights to demand transferring Byetta franchise to them.

Based on my experience (IMCL investor from 1998)with ImClone where Carl is the BOD Chairman, Carl is a greenmailer and knows nothing about complexity of biotech business. If not for IMCL's partner Merck KgaA who does all Erbitux R&D, IMCL would be long ago out of business.

Crude Oil Prices: Bears Will Soon Win Out

Mon, 26 May 2008 22:02:18 -0400

<>

Yes, it is true. But as long as
- US foreign and domestic deficits keep growing
- US Treasury and Fed are printing US$ as if there is no tomorrow

There is no way US$ will stop falling in a long-run.

Oil Is Up Due to Fundamentals, Not Speculation

Sun, 25 May 2008 00:11:53 -0400

Is any one on this board aware that US$ is becoming worthless on daily basis?

Just in the last 6 months, the Fed has printed over 800 millions US peso [sorry US$$$].

Commodities: Oil Correction Likely; No Gold Bubble

Sat, 24 May 2008 23:49:17 -0400

The US empire is a giant with clay feet is about to collapse.

How long will the rest of world sell to America goods for US peso?

The Oil Shortage, and Other Fairy Tales

Sat, 24 May 2008 16:09:33 -0400

In the last few months, the Fed flooded US economy with $800B newly-printed paper money.

In the last 3 years, US$ lost 50% against euro. Consequently, if commodities did not change in euro then their prices had to double in US$.

However, EU central banks are too printing a lot of new euros. Consequently, commodities had to go up in euro too. There are no ways to "print" commodities.

The author unfortunately does not mentioned that US government and US Congress totally irresponsible policies are the real reasons for the disastrous state of US economy and runaway commodities prices.

A Look at the Respective Rallies in Tech, Housing and Oil

Mon, 19 May 2008 09:04:20 -0400

The tech bubble was just a pure speculation. There was no real substance under it.

The present housing bubble was a child of excessive greed and a big fraud on a part of the Wall Street and securities rating agencies. The government and the Congress also made a major contribution to the problem.

Now, we come to a commodities "bubble". Well, the Feds and the Treasury are printing money as crazy trying to solve financial and housing problems through inflation. However, the commodities are the real stuff. Their is no way it can be "printed".

Consequently, the is no commodity bubble now yet. The commodities prices just reflect the present inflation adjusted prices. Please note the commodities prices are much more inflated in US$ and than in euros.

The Dollar Is Currently Bottoming

Mon, 12 May 2008 22:45:10 -0400

The Dollar Is Currently Bottoming. Is this some kind of a joke?

Do they have problems printing $$$?

OK, OK, we do not have any inflation and/or humongous domestic and foreign/trade deficits!

Either the author is a clown or he thinks that all his readers are imbeciles.

Recent Anomalies in U.S. Stock Markets: Proof of Free Market Intervention?

Mon, 12 May 2008 22:02:38 -0400

MBIA posts huge loss on credit derivatives
May 12

NEW YORK (Reuters) - MBIA Inc, the world's largest bond insurer, posted a quarterly loss of $2.4 billion on Monday as it took charges on billions of dollars of exposure to bonds linked to subprime mortgages.

But MBIA's beaten-down shares rose more than 4 percent...
----------------------...
One might expect MBI, being close to a bankruptcy, stock would go down. No, it is up over 4%.

Well, we do know what did happen. But how long before oil will be over $250-400 a barrel.

The USA financial system became smoke & mirrors. It dose not reflect the realities. The Wall Street became too toxic to the Main Street America. It is just a fraud. A depression will be too nice but the USA are moving to an abyss.

Who's Really to Blame for Rising Oil?

Sun, 11 May 2008 17:37:04 -0400

Nobody speaks about a free-market system any more. Well, we did not have for a while.

I understand the frustration of all democrats and republicans: they can do nothing about oil prices. They can not create oil, gas, gold, etc., by "printing it" or out of taxing it. The best Congress can do is to create shortages...

In old good time, USA colonized almost all oil producing countries. The USA robed them and were happy calling ourselves a democracy. The rest of the world was poor and did not use much oil. Yes, it was good!

Now, the USA does not control the world oil supply. Russia, Iran, Venezuela are in control of their own oil. On top of it, China, India and the rest of world would like to enjoy good life too.
On top of this, the USA military is not in a position to dictate to the world how they suppose to live their lives and how be nice to America.
Adding these three together and the USA and EU have a problem.

So, get used to the reality!

Icahn Steals The Future of Enzon Pharmaceuticals

Sat, 10 May 2008 22:33:06 -0400

Enzon Pharmaceuticals is another good company about to be ruined by this greenmailer.

Well, during the last 10-15 years, the Wall Street Mafia has ruined America industrial base, financial institutions, good many new and most promising start-up companies and also corrupted to the core America political system.

Only the Oil Companies Win

Fri, 09 May 2008 23:52:59 -0400

Oil companies are not any different from any other successful businesses.

Idiots, politicians and demagogues love to blame successful businesses: oil/gas, pharmaceuticals, airspace, etc.,

As soon as these businesses lose their free-market opportunities, there will be energy supply shortages, no new life-saving drugs, etc.,

Stop Listening to Bankers' Talking Heads

Fri, 09 May 2008 23:09:49 -0400

"Capital markets need to be operated in the interests of the owners of capital, not for the servants in the form of financial services providers. The last 70 years have witnessed the biggest transfer of wealth as a percentage of all wealth created by man to the pockets of a few bankers and their Friends & Family.

For the benefit of society, this process must be reversed."

Today, the Wall Street Mafia owns America political system and the mass media.

The present financial crisis will ruin the "old boys and girls" system. We are on a brink of major cataclysms in American society.

Why Inflation Is Lower Than You Think

Thu, 08 May 2008 14:34:15 -0400

"The gov't is totally cooking the books on inflation measurement. "

What a surprise.

The USA government is not "by the people and for the people". It represents exclusively very narrow special interest groups. So, it must lie. They are no better than a used-car salesman.

Personally, I do not remember when the last time US President told truth. May be Ronald Reagan tried doing it occasionally.

How Much Worse Can It Get For Oil?

Wed, 07 May 2008 11:32:50 -0400

Why will commodities prices go down if the US Treasury and Feds as well as EU central banks are printing money like crazy?

Too bad, nobody in the US Treasury and Feds learned how to print oil, gas, gold, copper, etc.,

Bernanke Urges Action to Slow Foreclosures

Wed, 07 May 2008 11:11:13 -0400

Excellent article.

Why will anybody in a sound mind pay their mortgages? There are absolutely no reason for it!

PS
People do not understand the meaning of communism. Stalin stated: Everyone MUST contribute to the society accordingly to their abilities and everybody must be paid compensated accordingly their contribution.

This is perfect and I agree with it.
But there was one BIG problem: it were the Communist Party bureaucrats who developed and implemented the standards for required contributions and compensations. If someone did not meed the required contribution requirements, he and his family were sent directly to an extermination camp!

Warren Buffett Is Wrong on Fed Intervention in Bear Stearns

Tue, 06 May 2008 15:07:14 -0400

People sometime forgot that Mr. Buffett is a businessman. He runs and takes care of a very large investment company. His company is not much different from Goldman Saks and other investment banks. Therefore, the Fed is his business partner.

Consequently, the main driver behind every single statement he makes is well-being of his own company. So, do not be fooled by his appearances. He is not a monk. He is a very shrewed businessman.

Finally, big businessmen are all politicians! Do you trust them?

How To Solve the Housing Crisis Tomorrow

Fri, 02 May 2008 15:57:00 -0400

This is nice: if somebody can not or does not want to pay his/her mortgage, no problem since US government will pay for it.

Just a simple question: why will anyone in a sound mind pay his/her mortgages? There is no need for it. Just grab $100M mention and don't pay.

I like it very much.

Will New Proposed Fed Powers Threaten the Free Market?

Fri, 02 May 2008 12:01:00 -0400

I like the concept: a free market economy without a free market.

Shit, it did not work in the former Soviet Union or in Mao China.

Time for Biotech To Turn Around?

Fri, 02 May 2008 11:42:58 -0400

It is silly to speak about biotech in general. There are financially sound companies with great approved drugs and great pipelines. The rest are just smoke-and-mirrors whose management is in business exclusively to loot shareholders pockets.

The Commodities Bubble

Fri, 02 May 2008 11:17:22 -0400

May be there is a commodities bubble in US$ but not so much in euro.

US Treasury and Fed are printing US$$$ as crazy trying to solve us financial and housing bubbles through world wide inflation. It never worked in the past and will not work this time either.

I feel sorry for US Treasury, Fed and politicians but you just can not print commodities...