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  • Advanced Cell Technology Is Scaling Up Its Blood Program [View article]
    I have been wondering how long after the peer reviewed paper on platelets was publish last week before a SA author would write about it. Thanks Biocell for writing a very good article.

    This is a many times bigger pie than AMD and SMD and There is a high probability its development will be funded by the Defense Department or Homeland Security to the tune of many millions of dollars. If they do, then there will be no dilution, a big gain for ACTC. Some big pharma, seeing the potential, may buy ACTC (I hope not) -- before our government offers funding.

    I do not expect anything will happen until perhaps the beginning of the 2015 when the new CCO's work will bear fruit. In the meantime, Management can give us a clue at the Nov 12 Shareholder's Meeting.
    Oct 27, 2014. 12:19 PM | Likes Like |Link to Comment
  • Advanced Cell Technology Has Groundbreaking Results [View article]
    Universal Platelet. This is going to be a hugh business once approved by the FDA..... will dwarf SMD and AMD business. Unlike SMD and AMD which are one time treatment for individuals, platelets are always needed in clinics, hospitals, b y military medics, etc., to treat people who need blood transfusion.

    http://yhoo.it/1wrcBgd

    The need for a universal platelets is world wide. This is the kind of business that ACTC will need a big established pharma partner.

    Any opinion on this?
    Oct 20, 2014. 10:41 AM | 1 Like Like |Link to Comment
  • Advanced Cell Technology Has Groundbreaking Results [View article]
    News today on iPS cells based blood plasma created by ACTC will bring in income that is several fold bigger than SMD and AMD. Hundreds of Millions of sick people around the world need a universal germ/bacteria/virus free blood plasma that has a very long shelf life to survive treatments. This is the one product that could propel ACTC shares to reach over $100.
    Oct 17, 2014. 10:29 PM | 2 Likes Like |Link to Comment
  • Advanced Cell Technology Has Groundbreaking Results [View article]
    If I heard it right, AMD is 50 patients not 30.

    I think the reason for getting more SMD patients is because they are younger (some are only in their teens when they get it) and hence, cells will take better engraftment. Keep in mind ACTC asked the FDA for approval of Ph 1b which targets younger patients. Their experience with the older patients perhaps showed that they could possibly get much better results with younger patients. I was expecting them to say something about this during the CC but they did not. The SMD patient interviewed on NPR said he had great results.
    Oct 16, 2014. 01:44 PM | 1 Like Like |Link to Comment
  • Advanced Cell Technology Has Groundbreaking Results [View article]
    You can find more information here than from the CC this afternoon.

    http://bit.ly/11nVdNL?cmpid=RSS|NSNS|2012-G...
    Oct 15, 2014. 09:15 PM | 1 Like Like |Link to Comment
  • Advanced Cell Technology Has Groundbreaking Results [View article]
    The conference call was the same as the press release, with a little bit more information, delivered without passion in their voices. Very disappointing. The trial showed good results, confirming what many have speculated. But the presentation was so dry. Unless you have been following the trials progress these past 3 years, it does not sound like there is a bright future for the company. They seem to be so afraid of making forward looking statements. I am afraid the pps will be going south.

    However, when looked at in a rational way, the business should be good. As a minimum, the treatment arrests the progress of AMD and SMD. Because there is no treatment available, on stopping the disease progress alone, the process can be approved by the FDA, especially since 2/3 rds of the patients showed improvement in their vision. In Phase 2, with all patients to be treated with the higher dosage (150,000 cells or more depending on the results of the 200K dosage) it is likely the results will be the restoration of vision good enough "to ride on a horse" and see where one is going. [This is what was missing on the CC, details on who got better vision, the dosage and over what period of time. They just said it was safe and implied that the FDA gave them approval to proceed to Ph 2. Did they expect us to get a copy of the Lancet and read the article ourselves?]

    I hope someone who has access to the Lancet will read it and provide us with a trial result summary. I have high hopes on cell cures so I am holding on to my shares. In baseball parlance, ACTC Management opted to bunt today and made no attempt to make a hit.
    Oct 15, 2014. 07:40 PM | 1 Like Like |Link to Comment
  • Advanced Cell Technology Has Groundbreaking Results [View article]
    This is a disappointment. Second announcement and no Q & A. .... and little specifics on the trial results, just broad statements. They mentioned that they will be making presentations.... I hope there will be Q&A at that time.

    The Ph 2 timelines for SMD and AMD seem to be stretched relative to what they already know from Ph 1/2. I am afraid competitors are going to catch up and pass them.
    Oct 15, 2014. 04:55 PM | Likes Like |Link to Comment
  • Update: Advanced Cell Technology Interim Results And Shelf Offerings [View article]
    This is a big BS article from Esekla. Stopping deterioration of the eyes is a big deal. The untreated eye continued to deteriorate. But it is more than that. The patients can see to 4 levels in the eye chart .... from none. As Dr Lanza said, they can see enough to go horse riding. Here is the other article you should read:

    http://bit.ly/11nVdNL?cmpid=RSS|NSNS|2012-G...

    I am expecting ACTC's Dr Lanza will discuss trial results in detail this afternoon at the 1PM PST conference call. I hope he talks about the result of Phase 1b which is treatment of younger people at 150,000 cell dosage. That is the group that should get better results, perhaps bring it up to 20/40 at the very least.
    Oct 15, 2014. 12:09 PM | 6 Likes Like |Link to Comment
  • Advanced Cell Technology And Dilution: Do We Really Have A Rational Choice? [View article]
    Competition uses different methods to achieve the same goal. I believe, what research on stem/adult cells have shown, that stem cells have the advantage of lasting as long as a normal human life. Adult cells like iPSCs have limited life span and therefore, may not be suited to get long term multi year benefits. ACTC is the only one using HeSC.
    Oct 1, 2014. 03:23 PM | Likes Like |Link to Comment
  • A Repudiation Of Advanced Cell Technology's 'Whisper' Results [View article]
    Please note that one thing the teams does after cell injection is "look inside the eye" and see if the cells have implanted and if it is holding. If the eye has cataract or film, they cannot see inside the eye and therefore, will not know the result. The patient that is on trial should have no eye problem whatsoever that will impede full examination of the eyes. Hence the criteria on cataract time requirements.
    Sep 22, 2014. 05:09 PM | Likes Like |Link to Comment
  • A Repudiation Of Advanced Cell Technology's 'Whisper' Results [View article]
    As JMY stated, the patient's cataract was removed before he got treated with cells. However, the article implies that the reading of 20/400 was taken before the cataract surgery then gave the result as 20/40 after the cell treatment. This will be a careless mistake. I believe strongly that the scientists did it correctly. They took the reading of 20/400 just before cell treatment - which is long after the cataract surgery so the trial findings will not be affected -- then took another reading after the cell treatment and came up with the 20/40 result.
    Sep 22, 2014. 12:48 PM | 1 Like Like |Link to Comment
  • A Repudiation Of Advanced Cell Technology's 'Whisper' Results [View article]
    Could it have improved from 20/800 before cataract surgery to 20/400 after cataract surgery, then to 20/40 after cell implantation?
    Sep 22, 2014. 12:35 PM | 1 Like Like |Link to Comment
  • Advanced Cell Technology Annual Meeting Announcement: A Harbinger Of...? [View article]
    Further clarification. Numbing is done with eye drops which is done before you sit on the operating chair and take about 10-15 minutes to take full effect. No injection is involved --- at least not with Lasik surgery.
    Sep 16, 2014. 10:37 AM | Likes Like |Link to Comment
  • Advanced Cell Technology Annual Meeting Announcement: A Harbinger Of...? [View article]
    I had lasik surgery done on both eyes. They numb your eyes.... fell nothing... and tell you to fix your sight on a small rel light. After the top part is sliced, your vision goes blurred but you still hold your eye steady on that red light you can now almost not see. They plop back the top they cut and press out the fluid they used to wash out the laser generated debris. Vuola, your done and can see again..... more sharply. Procedure lasted about 15 minutes.

    I assume this cell injection is about the same but much faster since there is no cutting or post washing involved.
    Sep 16, 2014. 10:32 AM | Likes Like |Link to Comment
  • Advanced Cell Technology Annual Meeting Announcement: A Harbinger Of...? [View article]
    I beg to differ. Wet and Dry cell treatment have strong similarities -- the ability of cells to replace ( & restore) the functions of damaged cells. I did not say the Japanese were leading in their research. In fact, ACTC is ahead but not that much and will soon be surpassed because of the law passed in Japan less than a year ago that simplifies approval of stem cell treatments. The Japanese law was designed to overcome the long licensing processes that just delays unnecessarily the development and approval of treatments. They have watched what the FDA has been doing and they have instituted a legal path to simplify and speed up the process.... and still be ethical.

    ACTC has an edge, business wise. 85%-90% of AMD is the Dry type, 10-15% is Wet AMD. 90% of severe vision loss is the Wet type. In almost all cases Wet AMD starts out as Dry AMD. There is an estimated 50 million cases of AMD around the world.

    In the Japanese treatment, the damaged retina section is removed .... a difficult process .... and replaced with a section of grown iPS cells. On the other hand, Actc just injects the heSC (Trials indicate best efficacy is about 150-200,000 cells - about the volume of 3 pin heads) right into the macular area and the cells find its way to replace the damaged ones. Actual operation is only a few minutes. Waiting for the anesthesia to take effect takes longer. I cannot give any more details because ACTC never gave enough details in its presentations. The Japanese provide more info.
    Sep 15, 2014. 02:54 PM | Likes Like |Link to Comment
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