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  • Incyte and MedImmune collaborate on cancer immunotherapies [View news story]
    The combination immunotherapy of Anti-PD-L1 & IDO inhibitor should show a synergistic efficacy in combating cancer. As, a stage IV cancer survivor, I been researching combination for almost 10 years. The cure for cancer will be from combinatorial immunotherapy.

    Best regards,

    jimmy B
    May 14 10:45 AM | Likes Like |Link to Comment
  • AstraZeneca - Small Deal With Amplimmune Provides No Quick Fixes [View article]
    AZN made a great buy when it bought out Amplimmune. The drug AMP-514, which is an anti-programmed cell death (anti-PD-1) monoclonal antibody. The drug is in late-stage pre-clinical development and Amplimmune aims to file the drug with the relevant authorities before the end of this calendar year, Now with Anti-PD1, the can combine Tremelimumab (Anti-CTLA-4) the two checkpoint receptors on the T-cells to take the brakes off the immune system. They can now go head to head with Bristol Myers in the Oncology field. What a great accusation!
    Aug 27 09:02 AM | Likes Like |Link to Comment
  • Dendreon: New Provenge Trial Involves Drugs Shown To Shrink Tumors [View article]
    Ted, This clinical trial outcome will be a positive, While provenge is the activated T-cells, CT-011 is (Anti-PD-1) which blocks the checkpoint receptor PD-1 that is upregulated to the surface of the T-cell when it is activated.Cyclophospha... Kills the T-regulator cells that suppress the immune response.

    Putting them all together you get the perfect storm to jump-start the immune system in recognizing the cancer.
    Dec 10 10:07 AM | 1 Like Like |Link to Comment
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