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  • Digitaltradz [View instapost]
    Anybody try digital tradz ?
    Nov 14, 2009. 09:26 PM | Likes Like |Link to Comment
  • Mannkind: Overlooked Biotech With Excellent Prospects (Part III) [View article]
    Then why are institutions selling heavy this year? Seems that they would be able to do much more research then you and make a better judgement.

    On 2008 Jun 13 04:43 AM R.J Steffens wrote:

    > "This was yet another obstacle to prescribing Exubera, especially
    > since most doctors treating diabetics (i.e. general practitioners
    > and internists) do not have pulmonary testing equipment in their
    > offices. On the other hand, Mannkind found no evidence of any drop
    > in lung function whatsoever in their clinical trials with Technosphere
    > Insulin."
    > Mannkind has not reported detailed Phase III results, and did not
    > report the additional safety data at the ADA event like they stated
    > they planned on doing. The did have ana abstract showing absorbtion
    > occuring 8 minutes later for smokers then for non-smokers as measured
    > by "tmax". The FDA, in my opnion, would require a diabetic to undergo
    > pulmonary tests for technosphere (if it is ever approved). The diabetic
    > already is losing lung function due to the progression of the desease:
    > "(5) Chronic use of inhaled insulin may affect long-term pulmonary
    > function, while preexisting pulmonary dysfunction may alter the absorption
    > and bioavailability of inhaled insulin."
    > Another worth mentioning is Generex's Oral-lyn Buccal spray. Since
    > Oral-lyn also has a very rapid onset of action, and NO deposition
    > into the lungs, it seems as if it would be the choice amongst diabetics
    > between these two potential products. Technosphere is said to afford
    > low titration and Oral-lyn provides 1 U sprays as part of a fine
    > tune regimen. Technosphere has another large obstacle that Oral-lyn
    > does not- TI needs to be marketed as a product that does not cause
    > decreased lung function or lung cancer. Fair or not, that is a horrible
    > position to be in. I wish them well, and hope they all are approved
    > to give diabetics a new choice and lifestyle freedom. This is a freedom
    > they have in India with Oral-lyn.
    > Best wishes.
    Nov 4, 2009. 09:04 PM | Likes Like |Link to Comment