"Let us call to all the people for thrift and economy, for denial and sacrifice if need be, for a nationwide drive against extravagance and luxury, to a recommittal to simplicity of living, to that prudent and normal plan of life which is the health of the republic. There hasn’t been a recovery from the waste and abnormalities of war since the story of mankind was first written, except through work and saving, through industry and denial, while needless spending and heedless extravagance have marked every decay in the history of nations."
And this, along with the influx of European gold from the war-ravaged countries terrified of their confiscatory governments, brought us the roaring twenties. http://bit.ly/159Z9SE
Swine Flu AND Medical News Concentrator April 25, 2013 To ??? [View instapost]
That HuffPo link is a bit ambiguous about whether the canine kidney cell process would actually be used for full scale manufacturing or is still in the experimental stage for H7N9.
"When the genetic sequence for the virus became available on March 30, Robinson said, U.S. health officials decided to try the new synthetic biology technique to try to speed the process. That's when Novartis and Venter's company, Synthetic Genomics Vaccines Inc, went to work. By Thursday, April 4, they had synthetic DNA ready and had started to grow the virus in dog kidney cells."
So they have started experimenting.
But: "Shaw said the CDC plans to take a vaccine candidate at least to the stage of human safety trials" suggests it would need phase II type trials before it could be marketed, which would not be a six-week process.
Swine Flu AND Medical News Concentrator April 25, 2013 To ??? [View instapost]
There are newer technologies for growing or manufacturing vaccine products that do not use the tried and true chicken egg process. However, I am uncertain if any of them are developed to the scale needed to address a pandemic in the way the big manufacturers can scale up the egg process.
Here are a couple of discussions of the newer technologies:
As mentioned above, Novartis is in the game with canine kidney cell technology for its newest flu vaccine, announced last fall: http://bit.ly/13G7lp8
From the prescribing info: "FLUCELVAX (Influenza Virus Vaccine), a vaccine for intramuscular injection, is a “subunit” influenza virus vaccine prepared from virus propagated in Madin Darby Canine Kidney (MDCK) cells, a continuous cell line. These cells were adapted to grow freely in suspension in culture medium. The virus is inactivated with ß-propiolactone, disrupted by the detergent cetyltrimethylammonium bromide and purified through several process steps. Each of the 3 virus strains is produced and purified separately then pooled to formulate the trivalent vaccine."
Does anybody know if the canine kidney cell system is their plan for the H7N9 vaccine? Or would they use the traditional chicken egg method?
"Chinese officials suspect there may be cases of human-to-human transmission, which would be necessary for the outbreak to rise to pandemic levels. So far, the strain has infected 108 people, 22 of whom have died. If the strain proves to be a candidate for a pandemic outbreak, it might be a while before health professionals have a vaccine to protect against the strain, according to Joseph Kim, president of Inovio, a California-based company that is currently in the initial stages of developing an H7N9 vaccine."
""Smoked cannabis works faster, but oral THC works longer. For the management of chronic pain and other symptoms, the duration of action is often more important than the rapidity of onset. It is more convenient, and often more desirable, to administer a medication two or three times daily rather [than] every two or three hours," said Reisfield, who was not involved in the research."
"The study was published April 22 in the journal Neuropsychopharmacology."
The difference between brownies and joints has been known since ancient times, but "medical science" now makes it official.
Axion Power Concentrator 230: April 24: Axion Power On Panel At Energy Storage Economics 2.0 For New York City And Beyond [View instapost]
Cytokinetics is in my sock drawer. I think its tirasemtiv molecule has amazing potential for treatment of neuromuscular disorders, where there are not really any highly effective treatments yet.
All the pundits talk about it being a breakthrough for amyotrophic lateral sclerosis (Lou Gehrig's Disease), which it should be. But my interest is also in treatment for myasthenia gravis, which does not have the same PR cachet as ALS, but has twice the potential epidemiologic market. The lead investigators presented very robust phase II data last month: http://bit.ly/17byH9s
QC #256, April 12, 2013 [View instapost]
We love you despite the difficulties.
Keep dumpin' it!
Swine Flu AND Medical News Concentrator April 25, 2013 To ??? [View instapost]
"Aurora company creates first H7N9 avian influenza vaccine"
http://on9news.tv/Yj6yKg
QC #256, April 12, 2013 [View instapost]
Warren G. Harding, 1920.
http://bit.ly/q38NjV
And this, along with the influx of European gold from the war-ravaged countries terrified of their confiscatory governments, brought us the roaring twenties. http://bit.ly/159Z9SE
Axion Power International PbC Cost Estimating Spreadsheet [View instapost]
I like the comment annotations from you and JP that explain the assumptions.
Axion Power Concentrator 231: April 27: Axion Power On Panel At Energy Storage Economics 2.0 For New York City And Beyond [View instapost]
Bottom feeders' paradise today.
Swine Flu AND Medical News Concentrator April 25, 2013 To ??? [View instapost]
"When the genetic sequence for the virus became available on March 30, Robinson said, U.S. health officials decided to try the new synthetic biology technique to try to speed the process. That's when Novartis and Venter's company, Synthetic Genomics Vaccines Inc, went to work. By Thursday, April 4, they had synthetic DNA ready and had started to grow the virus in dog kidney cells."
So they have started experimenting.
But: "Shaw said the CDC plans to take a vaccine candidate at least to the stage of human safety trials" suggests it would need phase II type trials before it could be marketed, which would not be a six-week process.
Swine Flu AND Medical News Concentrator April 25, 2013 To ??? [View instapost]
Here are a couple of discussions of the newer technologies:
http://1.usa.gov/13G7j0e
http://bit.ly/ZL74CM
As mentioned above, Novartis is in the game with canine kidney cell technology for its newest flu vaccine, announced last fall: http://bit.ly/13G7lp8
From the prescribing info:
"FLUCELVAX (Influenza Virus Vaccine), a vaccine for intramuscular injection, is a “subunit” influenza virus vaccine prepared from virus propagated in Madin Darby Canine Kidney (MDCK) cells, a continuous cell line. These cells were adapted to grow freely in suspension in culture medium. The virus is inactivated with ß-propiolactone, disrupted by the detergent cetyltrimethylammonium bromide and purified through several process steps. Each of the 3 virus strains is produced and purified separately then pooled to formulate the trivalent vaccine."
Does anybody know if the canine kidney cell system is their plan for the H7N9 vaccine? Or would they use the traditional chicken egg method?
More Reasons To Call Off The Reinhart-Rogoff Witch Hunt [View article]
http://bit.ly/18a7mCb
Swine Flu AND Medical News Concentrator April 25, 2013 To ??? [View instapost]
http://bit.ly/14zAaI1
"Chinese officials suspect there may be cases of human-to-human transmission, which would be necessary for the outbreak to rise to pandemic levels. So far, the strain has infected 108 people, 22 of whom have died. If the strain proves to be a candidate for a pandemic outbreak, it might be a while before health professionals have a vaccine to protect against the strain, according to Joseph Kim, president of Inovio, a California-based company that is currently in the initial stages of developing an H7N9 vaccine."
(INO) another penny stock to watch.
QC #256, April 12, 2013 [View instapost]
"The study was published April 22 in the journal Neuropsychopharmacology."
The difference between brownies and joints has been known since ancient times, but "medical science" now makes it official.
Stability Of The European Union (19) April 18, 2013 To [View instapost]
http://bit.ly/12NzefY
QC #256, April 12, 2013 [View instapost]
-Milton "Kermit" Friedman
QC #256, April 12, 2013 [View instapost]
Axion Power Concentrator 230: April 24: Axion Power On Panel At Energy Storage Economics 2.0 For New York City And Beyond [View instapost]
All the pundits talk about it being a breakthrough for amyotrophic lateral sclerosis (Lou Gehrig's Disease), which it should be. But my interest is also in treatment for myasthenia gravis, which does not have the same PR cachet as ALS, but has twice the potential epidemiologic market. The lead investigators presented very robust phase II data last month: http://bit.ly/17byH9s
Axion Power Concentrator 230: April 24: Axion Power On Panel At Energy Storage Economics 2.0 For New York City And Beyond [View instapost]
That could also be phrased as "How did they do it -- missionary style or doggie style?"