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JustTwice

JustTwice
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  • Buying Dendreon on Thursday's Plunge [View article]
    Amazing piece! Ignorance is bliss. Sadly the drop in DNDN pps will allow ungrateful and mis-informed people like you the ability to capitalize on something that "doesn't matter" right?

    It extended like by 4.1 months? Wrong. The median survival over PLACEBO was 4.1 months. Meaning (let's say this slowly so you understand) half of the patients lived L O N G E R then 4.1 months and half S H O R T E R. Some patients continues to live 6-7 years removed (guess thats not worth 93k either)?

    Speaking of Placebo...Do you happen to know what that is? Stupid question on my part as you clearly don't have a clue. Perhaps you can familiarize yourself with "FROvenge". Because in the Dendreon studies when patients in the Placebo group progressed past a certain stage they were administered FROvenge. Which since you have not a clue about the study is a frozen version of Provenge that in itself has shown a survival benefit. So ultimately Provenge was competing against a version of itself.

    Follow up studies show that the median survival of Provenge over placebo could be closer to 7 months. And again meaning HALF live longer then 7 months.

    Nothing mentioned of the fact that those who took provenge had a 3 year survival benefit of 38% over those who didn't take Provenge. I guess you wouldn't want a shot at being in that lofty percentage of people right? Hopefully you notice that it's called the "3 year" survival benefit. Can you take a guess at why? O thats right. Thats because people are still living past 4.1 months like you've so ridiculous failed to mention in your piece. How can they determine an advantage at 3 years if everyone is gone and money was wasted? Get a clue. People are living years beyond.

    And about those years beyond. Any mention from you about the safety profile? Perhaps you've never had prostate cancer or known anyone afflicted by the disease. Thats rather clear and Karma is a bitch, so I wish you well there. But perhaps if you knew the pains that are associated with the progression of this disease you wouldn't act as though someone should sit quietly as they await death. Provenge has little to NO side effects. And reduces pain associated with the disease.

    Lastly consider this. This trial was run on patients who were the sickest of the sick. They all had a death sentence awaiting. Provenge has shown that over time it works best. The earlier the better.

    The studies revealed that patients who had a gleason score = 7 who received Provenge had twice the chance of those on placebo of remaining progression free and free of cancer related pain while on the study.

    Adding color to that above. Those who received provenge and disease didn't progress 6 months after randomization had a greater than 8 X advantage in progression free survival over those who received placebo.

    And FYI the vast majority of newly diagnosed patients with hormone resistant prostate cancer (dendreons approved label) have gleason scores of 6 or 7.


    So there you have it. You're a moron and someone who can't quick appreciate breakthroughs in science. A person that SA has decided is worth of writing an article of which I'd beg to differ.

    Dendreons management team has dropped the ball. So not all is peachy in DNDN world. But to question the advantage and the cost is so utterly ridiculous that you deserve to be taken to school on the subject.
    Aug 5 09:11 AM | 13 Likes Like |Link to Comment
  • Dendreon Continues to Suffer From Misleading Reports [View article]
    Happy to see someone shine some light on Feurestein...The more times he's brought to shame the better...He's the epitome of what's wrong with todays captured America...I can care less if he ever gets caught...That pig and his family have to deal with him being a pathetic excuse of life...
    Jul 29 11:26 AM | 7 Likes Like |Link to Comment
  • Cancer Vaccines: Northwest Biotherapeutics vs. Dendreon [View article]
    Garza has every ability to try and defend himself and this piss poor article in the comments section...And what do we hear from him?

    *crickets*


    Thats right...Scam artist brought to light...Thought he could get away with a quick hit and run article but failed to realize just how plugged in Dendreon investors are...

    What a tard...
    Jul 20 11:50 AM | 6 Likes Like |Link to Comment
  • Dendreon: Fear is Our Friend [View instapost]
    Great...Now I challenge any of those so called "experts" or "dr's" who are writing about Provenge to refute any of the information in this article...Then we'll know who's really full of $hit...
    Jul 7 02:37 PM | 9 Likes Like |Link to Comment
  • Dendreon and Provenge: What if We Lived in England? [View article]
    Another Dr. Who provides his analysis on Provenge...And concludes it may not be "worth" it...Yet makes no mention of the current standard of care treatment (Taxotere) and the yearly costs associated with it and it's terrible side effects...

    Doc, if it's so easy for drug companies to come out with better and cheaper products than why aren't we seeing them? How long has Taxotere owned this market to itself?

    I'd hate for you or your family to ever find out just how different the quality of life with Provenge is from Taxotere...Let me know then if costs matter to you and yours...

    Cheers
    Jul 7 08:59 AM | 10 Likes Like |Link to Comment
  • Five Key Factors Weighing on Dendreon [View article]
    John - J...

    Please don't insult everyones intelligence with your "trial" design flaws you're writing about. The FDA is responsible for diagnosing whether or not there are trial designs. Talk your book all you want. But Provenge stood up to 2 PIII trials and received FDA approval. Your trial design fight is over, you've lost that battle. FYI
    Jul 2 02:12 PM | 4 Likes Like |Link to Comment
  • Five Key Factors Weighing on Dendreon [View article]
    Let me ask you Michael...If you take such offence to someone commenting on your articles then why write for a site that allows people to comment? Go write a book...I'm not here to argue...I'm here to say that your article came across with some bias...Why that bothers you if you had no biased intent is beyond me...

    With regards to your offer of becoming a writer, I'll respectfully decline...I'm rather satisfied with my career...

    Cheers
    Jul 2 11:00 AM | 2 Likes Like |Link to Comment
  • Five Key Factors Weighing on Dendreon [View article]
    I'm happy to see you use Median Survival in your comment back to me...You're article would have come off much more sincere had you used that word to begin with and maybe even given an explanation of what "median" means to those who choose not to understand it...

    Rather then "demonstrated to extend survival by 4.1 months"

    Which to me sounds like 4.1 months is what you get out of provenge...

    Thanks
    Jul 2 10:16 AM | 1 Like Like |Link to Comment
  • Five Key Factors Weighing on Dendreon [View article]
    Michael...Fair enough...And I'm certain you dont appreciate being lumped in with those others as they have motives that are as defined as my opinion in my posts...

    I understand the idea for this article was to define why the Dendreon price has collapsed...But there are so many other contributors (general market conditions which happened to occur the day after Provenge approval, phantom articles with growing production, reimbursement, and compeition concerns AKA the short cartel)

    Tons of forces at work here (including gold and his ridiculous sales as you mentioned)...But the potential for Provenge in ex-us markets is 2 times that of the US (Hans words) and Dendreon is beginning the process for EMEA approval...The numbers are hard to ignore...

    And regardless of competition...Many companies will struggle to have the safety profile of Provenge...And knowing that no company in the past has ever suceeded at having an Immunotherapy approved it should give confidence to Dendreon shareholders that the barries will be tough to break down...

    Cheers
    Jul 2 10:00 AM | 4 Likes Like |Link to Comment
  • Five Key Factors Weighing on Dendreon [View article]
    Dan...You are correct...By law the Medicare NCA is supposed to show no bias towards cost of treatment...

    And to be fair to the original author you never mentioned average...However, you fall short in the full description of the advantages of Provenge...Much like anyone else I've seen from seeking alpha or thestreet.com...And I can't imagine you're ok being lumped in with those writers...

    And I'm sorry but whether or not the word "average" is used you imply that a patient going after provenge will get 4.1 months of extra life and pay $23k per month of extra life:

    "In view of the fact that Provenge has been demonstrated to extend survival by 4.1 months, this translates into an average cost of $23,000 per month of added survival."

    And your lack of mentioning that the cost for Provenge in the Medicare NCA is legally not to be used for reasoning of accepting or declining reimbursement is also upsetting..As I'm sure you know this as fact...

    Cheers
    Jul 2 09:36 AM | 3 Likes Like |Link to Comment
  • Five Key Factors Weighing on Dendreon [View article]
    Hard to follow an author that makes mention of the COST of treating side effects...But doesn't put any value into not having any side effects...

    Quick...Somebody ask me if I'd rather pay $14,000 (before purchasing side effect drugs) and having to deal with those very side effects or $23,000 and go about my golf round the very next day...Sounds rhetorical doesn't it?

    Better yet...Love an author who claims that the average exstention of life is 4.1 months...Let me guess, you never read any of the actual journals? You got your provenge fix from the very same authors who have lended an obvious hand to the drop in stock price...It's a MEDIAN survival of 4.1 months...Not average...I'll say it again so that you can correct it in your article...MEDIAN survival of 4.1 months...Do you know what that means? That means that half the patients in the Provenge group lived LONGER then 4.1 months...Some as long as 8 years and counting...You ready to put a price tag of the treatment on that?

    O and lost in your biased translation is that Provenge activates the immune system to recognize and fight the cancer...Which is why over time Provenge is more effective...Sooo, one can surmise that if Provenge is given to a healthier patient at the onset of being diagnosed with Prostate cancer...That the vaccine could work wonders with survival being measured at multiples of what we've seen with terminally ill patients whose immune systems are already shattered beyond recognition thanks to the CHEMO and other treatments they've already attempted...

    Best of luck in your future articles...A bit too easy to spot your motives...

    Cheers
    Jul 2 08:32 AM | 8 Likes Like |Link to Comment
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