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  • Organovo launches first product as a service [View news story]
    ONVO is banking on "later stage" pre-clinical drug discovery... AKA... very little through-put and high cost. Not only is this lower compound turnover area for pharms, as few compounds remain in the pipeline at this stage, but it also requires huge upfront validation from both ONVO and then with again with pharma customers themselves. I don't see any evidence on ONVO website that this testing has been conducted. ( versus.. InSphero website on liver characterization data) Pharm will test by recapitulating former in-house (In Vivo) data on both proprietary and proto-typical reference compounds. Build evidence that then justifies the ONVO technology. Only once this has been completed would the technology be used for investigative toxicology departments or further continued use as safety profiling platform. At "later stage" pre-clinical drug discovery most companies are using in vivo (rats, dog, non-human primate) data to predict human liver safety concerns. Thus the ONVO must be able to predict equally as well as animal models (tough road).
    Conversely - it seems Hepragen, Hurel ,InSphero,and others who are producing advanced liver models, seek to enter the higher throughput arena within safety groups at these large Pharma houses. These technologies are focused on better predicting current established in vitro assays such as simple monolayer hepatocyte cultures, so that the early screening programs become better predictions of later stage in vivo data or even clinical data. This requires a lower price point and a lower hurdle for the targeted assays and associated technologies and not what ONVO seems to be peddling... preliminary compound screening versus the aforementioned "later-stage" preclinical testing are unique departments in the pharmaceutical industry and anyone investing should make sure they are familiar just where and how the intended technology is marketed to plug into the drug development pipeline.
    Nov 24, 2014. 08:52 AM | Likes Like |Link to Comment
  • With Cameras Rolling, Worlds Inc. Battles Activision Blizzard October 3 [View article]
    I'd spoke to Lisa on Monday, HJ Caspers courtroom clerk. She noted that there was never a confirmed video recording of the MM scheduled. There was no last moment decision by the judge.

    I would like to know on what basis did PP's "predict" a video recording or "streaming" of the MM hearing would be available?

    I think this is important since it was the theme of this SA article.

    Thx.
    Oct 7, 2014. 07:09 AM | 2 Likes Like |Link to Comment
  • Worlds +37.9% after Activision Markman Hearing completed [View news story]
    How could Worlds after Activision was granted a summary judgment declaring Worlds patent claims covering online gaming virtual worlds to be invalid have a markman hearing on the same if the patents were claimed invalid.

    I think the update requires a bit more color to help connect the dots.

    Thanks
    Oct 6, 2014. 12:16 PM | Likes Like |Link to Comment
  • With Cameras Rolling, Worlds Inc. Battles Activision Blizzard October 3 [View article]
    PP's what are you basing your expectations for a video release?

    Did you check on this, because I did and there's no video.

    I think you owe us all an explanation since this was the title theme of your article. While I find this case provocative and investable, I absolutely hate misinformation and just know that this places much doubt on anything you have might pen in the future on this or any other patent plays.
    Oct 6, 2014. 09:51 AM | 1 Like Like |Link to Comment
  • With Cameras Rolling, Worlds Inc. Battles Activision Blizzard October 3 [View article]
    From where or whom did you draw any understanding of a video broadcast of the hearing?

    THX
    Oct 6, 2014. 09:46 AM | Likes Like |Link to Comment
  • With Cameras Rolling, Worlds Inc. Battles Activision Blizzard October 3 [View article]
    Why did you claim the hearing would be recorded? Where did you receive this information? I've checked with HJ Casper's courtroom clerk and she mentioned there never was a plan for any video of this hearing?

    Your credibility just sank a few meters.
    Oct 6, 2014. 07:51 AM | 3 Likes Like |Link to Comment
  • With Cameras Rolling, Worlds Inc. Battles Activision Blizzard October 3 [View article]
    PP's

    I just received a reply email from Lisa Hourihan, Courtroom clerk to Honorable Judge Denise J. Casper:

    She states there will be no video of Friday's WDDD/ATVI marksman hearing.
    In my mind this diminishes your credibility!
    Oct 6, 2014. 07:35 AM | 2 Likes Like |Link to Comment
  • With Cameras Rolling, Worlds Inc. Battles Activision Blizzard October 3 [View article]
    Hey Princeton,

    ANY update on the video??
    Oct 3, 2014. 04:09 PM | Likes Like |Link to Comment
  • With Cameras Rolling, Worlds Inc. Battles Activision Blizzard October 3 [View article]
    PP's

    Just what is being "streamed" today relative to the hearing? Streamed in my mind conjures up a live video presentation.

    Don't you mean recorded and available at a later time?
    Oct 3, 2014. 11:07 AM | Likes Like |Link to Comment
  • With Cameras Rolling, Worlds Inc. Battles Activision Blizzard October 3 [View article]
    PP's

    "Activision Blizzard's last 10-K reported annual sales of more than $5 billion. Is it reasonable to conclude a $1 billion dollar potential liability should have some level of shareholder disclosure, especially when it represents more than 20% of annual revenues?"

    Didn't Judge Casper limit the damages period from only the certificate of correction forward. Doesn't this limit the damages from the original potential 'billion" to only a couple hundred million? a much smaller percentage of total revenue and thus maybe not 10K worthy?
    Oct 3, 2014. 08:02 AM | 2 Likes Like |Link to Comment
  • Worlds Inc.: An Interesting Run-Up Before A Crucial Markman Hearing [View article]
    @CJ4545

    I believe many investors will extrapolate questions asked by the judge into potential outcomes of how she will adjudicate the Markman hearing. Hearing her reaction to answers with follow-up questions will glean into how she may be leaning on construction claims.
    Oct 2, 2014. 01:41 PM | Likes Like |Link to Comment
  • Vringo: After The Federal Circuit Decision [View article]
    Yellow bars are Sua Sponte and the orange bars are granted (21%)
    Oct 2, 2014. 07:21 AM | Likes Like |Link to Comment
  • Vringo: After The Federal Circuit Decision [View article]
    My assumption is that the En Banc review is based on the merits of the de novo ruling on Obviousness, which by the way seem very weak. The weakness based on the review and validation these patents had received prior... USPTO, honorable Judge Jackson, and the jury.Seems to me that VRNG has more than a good shot to have this reheard with Chen's dissent and the best of the best arguing this issue.

    Thus, I would like to know your (and others) thoughts on what more a case like this would need to be reheard? I believe we have a 50/50 chance!
    Oct 2, 2014. 07:15 AM | 5 Likes Like |Link to Comment
  • Vringo: After The Federal Circuit Decision [View article]
    I thought maybe due to CAFC Judge Chen's strong dissent and the David Boies arguing the plea for En Banc, you might be more optimistic in the case being reheard? Do either of these add more favorable position for VRNG to be reheard?
    Oct 1, 2014. 01:41 PM | 3 Likes Like |Link to Comment
  • Organovo: Competition And Profit Potential [View article]
    I actually work inside the liver toxicology industry. I've spoken to customers of InSphero and those who have been approached by Organovo. The InSphero system has been adopted by major Pharma companies who have invested hundreds of thousand's in dollars, validating the advanced 3D liver models inhouse. These same companies have been approached by Organovo for early assessment and the cost was outrageously expensive and told not practical for these discovery tox groups due to the pricing. One investigator compared the cost as 10X more per compound via ONVO vs. INSPHERO. I think the ship has already sailed regarding advanced liver models which offer translatable human data.
    Oct 1, 2014. 01:36 PM | 4 Likes Like |Link to Comment
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